A5039339015- Genetics, Aging, and Longevity in Model Organisms
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Trace Elements in Health
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Genetic and Kidney Cyst Diseases
- Pharmacological Receptor Mechanisms and Effects
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Genetic Syndromes and Imprinting
- Diet and metabolism studies
- Biochemical Acid Research Studies
Florida Atlantic University
2018-2024
General Immunohistochemistry protocol
Cuprous copper [Cu(I)] is an essential cofactor for enzymes that support many fundamental cellular functions including mitochondrial respiration and suppression of oxidative stress. Neurons are particularly reliant on production ATP, with neurodegenerative diseases, Parkinson’s disease, associated diminished function. The gene MBLAC1 encodes a ribonuclease targets pre-mRNA replication-dependent histones, proteins recently found in yeast to reduce Cu(II) Cu(I), when mutated disrupt ATP...
Across phylogeny, glutamate (Glu) signaling plays a critical role in regulating neural excitability, thus supporting many complex behaviors. Perturbed synaptic and extrasynaptic Glu homeostasis the human brain has been implicated multiple neuropsychiatric neurodegenerative disorders including Parkinson's disease, where theories suggest that excitotoxic insults may accelerate naturally occurring process of dopamine (DA) neuron degeneration. In C. elegans, mutation glial expressed gene,...
Metabolic changes have been extensively documented in neurodegenerative brain disorders, including Parkinson's disease and Alzheimer's (AD). Mutations the C. elegans swip-10 gene result dopamine (DA) dependent motor dysfunction accompanied by DA neuron degeneration. Recently, putative human ortholog of (MBLAC1) was implicated as a risk factor AD, disorder that, like PD, has associated with mitochondrial dysfunction. Interestingly, AD MBLAC1 arises subjects cardiovascular morbidity,...
Metabolic changes have been extensively documented in brain tissue undergoing neurodegeneration, including Parkinson's disease and Alzheimer's (AD). Mutations the C. elegans swip-10 gene result dopamine (DA) dependent motor dysfunction accompanied by DA neuron degeneration. Recently, putative human ortholog of (MBLAC1) was implicated as a risk factor AD, that like PD, has associated with mitochondrial dysfunction. Interestingly, AD MBLAC1 arises subjects cardiovascular morbidity, suggesting...
Abstract Cuprous copper (Cu(I)) is an essential cofactor for enzymes supporting many cellular functions including mitochondrial respiration and suppression of oxidative stress. Neurons are particularly dependent on these pathways, with multiple neurodegenerative diseases, Alzheimer’s disease (AD), Parkinson’s disease, associated their dysfunction. Key features Cu(I) contributions to neuronal health in vivo remain be defined, owing largely the complex processes involved production,...
Abstract The nematode Caenorhabditis elegans is well known for its ability to support forward genetic screens identify molecules involved in neuronal viability and signaling. proteins C. dopamine (DA) regulation are highly conserved across evolution, with prior work demonstrating that the model can serve as an efficient platform novel genes disease‐associated processes. To players DA signaling, we took advantage of a recently developed library pre‐sequenced mutant nematodes arising from...