A5002984702- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- Immune cells in cancer
The University of Texas Southwestern Medical Center
2020-2023
Cincinnati Children's Hospital Medical Center
2019-2023
Southwestern Medical Center
2020
Significance Macrophages initiate inflammation to eliminate invading microbes. Following clearance of inflammatory stimuli, macrophages down-regulate genes and express repair protect host tissues from damage. Here, we find that the adaptor B-cell adapter for PI3K (BCAP) facilitates this transition reparative macrophages. Absence BCAP in limits ability mice intestinal following Toll-like receptor stimulation, undergo aerobic glycolysis results lactate production, a process compromised...
Intestinal epithelial cells (IECs) constitute a critical first line of defense against microbes. While IECs are known to respond various microbial signals, the precise upstream cues regulating diverse IEC responses not clear. Here, we discover dual role for IEC-intrinsic interleukin-1 receptor (IL-1R) signaling in intestinal homeostasis and inflammation. Absence IL-1R abrogates homeostatic antimicrobial program including production peptides (AMPs). Mice deficient unable clear Citrobacter...
Abstract Intestinal epithelial cells (IECs) provide a critical first line of defense against microbes through barrier function, production antimicrobial peptides (AMPs), secretion cytokines, and recruitment inflammatory cells. Whether single or multiple upstream cues regulate this diverse set responses from IECs is not clear. Here we discover an unexpected role for Interleukin-1 Receptor (IL-1R) signaling in regulating intestinal homeostasis inflammation. Specifically, absence IL-1R...