- Immunotherapy and Immune Responses
- Rough Sets and Fuzzy Logic
- Peptidase Inhibition and Analysis
- Data Mining Algorithms and Applications
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Data Management and Algorithms
- Immune cells in cancer
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Diabetes Management and Education
- Cardiac Health and Mental Health
- Cancer Research and Treatments
- Biochemical and Molecular Research
- CAR-T cell therapy research
- Laser Applications in Dentistry and Medicine
- Sexual function and dysfunction studies
- Chronic Disease Management Strategies
- Nanoparticle-Based Drug Delivery
- Ovarian cancer diagnosis and treatment
- Tumors and Oncological Cases
- Head and Neck Anomalies
- Electrolyte and hormonal disorders
- Metabolism, Diabetes, and Cancer
- Renal Diseases and Glomerulopathies
National Defense Medical Center
2013-2025
Tri-Service General Hospital
2013-2025
Taiwan Adventist Hospital
2018-2022
Weatherford College
2020
Qingdao University
2018
Affiliated Hospital of Qingdao University
2018
National University of Kaohsiung
2012-2015
Bellingham Technical College
2015
China Medical University
2009
Myometrial invasion affects the prognosis of endometrial cancer. However, discrepancies exist between pre-operative magnetic resonance imaging staging and post-operative pathological staging. This study aims to validate accuracy artificial intelligence (AI) for detecting depth myometrial using a deep learning technique on images. We obtained 4896 contrast-enhanced T1-weighted images (T1w) T2-weighted (T2w) from 72 patients who were diagnosed with surgico-pathological stage I carcinoma. used...
Type D personality (TDP) has been recognized as a risk factor for many diseases. The aims of our study were to estimate the prevalence TDP and glycemic control on patients with type 2 diabetes mellitus (T2DM) assess their relationship between socio-psychological factors, such perceived stress, self-efficacy, self-care behaviors, psychological distress.A total 198 T2DM (male 62.6%, mean age 51.2±11.0, HbA1c 7.3±1.8%) recruited consecutively from Department Endocrinology regional hospital in...
Abstract Background: Patients with recurrent ovarian cancer often face difficulty choosing treatment such as chemotherapy or targeted therapy. Here, we designed this patient decision aid (PDA), which presents therapeutic efficacy and cost to help patients make appropriate personalized decisions. Materials Methods: A PDA was developed according the International Standards (IPDAS), α β tests were conducted on 14 healthcare professionals 10 public representatives test participants. Results:...
Abstract Rationale: The new vaccines are emergently authorized and currently approved for use to protect against the coronavirus disease 2019 (COVID-19) pandemic serious adverse events uncommon. Moyamoya (MMD) with autoimmune is a rare entity usually presents intracranial hemorrhage in adults. Patient concerns: We reported 40-year-old female patient Sjogren thyroiditis, who had received second dose of Moderna (mRNA-1273) vaccination. Three days later, she presented left intraventricular...
Antiangiogenic therapy, such as bevacizumab (BEV), has improved progression-free survival (PFS) and overall (OS) in high-risk patients with epithelial ovarian cancer (EOC) according to several clinical trials. Clinically, no reliable molecular biomarker is available predict the treatment response antiangiogenic therapy. Immune-related proteins can indirectly contribute angiogenesis by regulating stromal cells tumor microenvironment. This study was performed search biomarkers for prediction...
Ectopic thyroid tissue presenting at the base of tongue, called lingual thyroid, is a clinical rarity. Clinical presentation varies depending upon either severity regional symptoms associated with enlargement gland size, or features related to dysfunction.We reported case 29-year-old female who presented easy fatigue and depression for 3 months.After series diagnostic workup, severe hypothyroidism was diagnosed.She received conservative treatment hormone replacement improved...
Ankle sprain is one of the most common sport injuries during landing counter movement jump and straddle in baseball volleyball exercise. patients will lead to ankle functional instability. Most instability occurs recurrent sprain. The purpose this study are estimate joint kinetics ground impact pattern jump. comparison between group control were also evaluated. result showed that injury risk much higher than because shorter time reach peak force Also, high impulses landing.
Epithelial ovarian cancers (EOCs) are fatal and obstinate among gynecological malignancies in advanced stage or relapsed status, with serous carcinomas accounting for the vast majority. Unlike EOCs, borderline tumors (BOTs), including BOTs, maintain a semimalignant appearance. Using gene ontology (GO)-based integrative analysis, we analyzed set databases of BOTs dysregulated GO terms pathways identified multiple differentially expressed genes (DEGs) various aspects. The SRC (SRC...
Objectives: Histamine is an important chemical mediator in both nasal and bronchial inflammation patients with allergic rhinitis asthma. The effect of histamine receptor-1 antagonists on mucosa vivo well known, however, the tracheal smooth muscle has rarely been explored. purpose this study was to determine effects fexofenadine isolated vitro. Methods: Six strips were used for each experiment, one untreated strip served as a control. We examined effectiveness rat by testing on: 1) resting...
This work presents an efficient approach for deriving itemsets with high fuzzy utility values from quantitative data. Each item in a transaction has its own profit and quantity, the total of it is considered. We also design useful strategy to prune unpromising candidate itemsets, thus making mining process efficient. Through series experimental evaluations, results show proposed could perform well mining.
Objective: To investigate the pathogenic mechanism of two novel ITGB2 mutations in leukocyte adhesion defect type 1 (LAD1). Methods: The clinical history and blood sample an 11 years old patient admitted to Affiliated Hospital Qingdao University August 2014 were collected. Expression CD18 (encoded by ITGB2) was analyzed flow cytometry. Novel identified next-generation sequencing technology confirmed Sanger sequencing. functional effect detected PolyPhen2. vectors both wild mutant constructed...
Dipeptidyl peptidase-4 (DPP-4) inhibitors are the most popular oral antidiabetic drugs (OADs) in recent 20 years because of low risk hypoglycemia, intermediate efficacy to lower glycated hemoglobin (△HbA1c): 0.5-0.9%, neutral effect on body weight change, convenience for usage (mostly once daily), and rare occurrence major side effects. The purpose this study was determine important predictors naïve use DPP-4 Taiwanese patients with type 2 diabetes mellitus (T2D).A retrospective...
Leiomyomatosis peritonealisis disseminata (LPD) is a rare benign tumor characterized by the dissemination of smooth muscle-like cell nodules within peritoneal cavity. Diagnosing LPD challenging for clinicians due to its nonspecific clinical presentation and throughout cavity, which mimics intra-abdominal malignancy. In present study, we case 47-year-old woman with severe abdominal pain fever initially diagnosed abscess or carcinomatosis. Exploratory laparotomy was performed resect several...
By continuously enhancing the blood flow, far-infrared (FIR) textile is anticipated to be a potential non-pharmacological therapy in patients with peripheral vascular disorders, for instance, end-stage renal disease (ESRD) undergoing hemodialysis (HD) and experiencing vasculogenic erectile dysfunction (VED). Hence, we manufactured novel polymer composite, namely, germanium-titanium-π (Ge-Ti-π) aimed evaluate its characteristics quality. We also investigated immediate long-term effects of on...
This paper proposes an efficient fuzzy mining approach, namely GDF, to speed up the execution efficiency of finding frequent itemsets in a quantitative database. Unlike existing approaches, proposed GDF adopts data-reduction strategy effectively reduce number unpromising candidate for mining. The experimental results on synthetic dataset reveal that approach could outperform traditional algorithm.
Purpose: Improvements in insulin resistance have been observed by following lifestyle modification (LM) for adults with metabolic syndrome (MetS). However, these improvements are associated relatively intensive and long-term duration LM, which is unlikely to be a part of routine practice most people. This study examined the impact short-term (eight-week) low-intensive LM program on anthropomorphic parameters community-based population. Patients methods: A total 174 (67 MetS) were enrolled...