A5045737284- Asymmetric Synthesis and Catalysis
- Biological Activity of Diterpenoids and Biflavonoids
- Chemical Synthesis and Analysis
- Coordination Chemistry and Organometallics
- Natural product bioactivities and synthesis
- Crystallization and Solubility Studies
- Synthesis of Organic Compounds
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Cell Adhesion Molecules Research
- Synthesis and Catalytic Reactions
- Plant-derived Lignans Synthesis and Bioactivity
- Crystallography and molecular interactions
- Traditional and Medicinal Uses of Annonaceae
- Molecular spectroscopy and chirality
- Chemical synthesis and alkaloids
- Synthesis and pharmacology of benzodiazepine derivatives
- Fungal Plant Pathogen Control
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Various Chemistry Research Topics
- Advanced Synthetic Organic Chemistry
- Synthesis and Reactivity of Sulfur-Containing Compounds
Centre National de la Recherche Scientifique
1999-2025
Université Paris Cité
2002-2025
Cibles Thérapeutiques et conception de médicaments
1999-2025
Sorbonne Paris Cité
2025
Délégation Paris 5
1999-2024
Molécules d'Intérêt Biologique
2004-2010
Pharmac
2009
Département de Pharmacochimie Moléculaire
2005-2006
Département de Chimie Moléculaire
2005-2006
Descartes (Belgium)
1999
Background: Chronic inflammatory diseases are rising, driving the search for effective natural treatments. Mentha pulegium L. and Pimpinella anisum (anise) exhibit notable anti-inflammatory properties individually, but their combined effects less stud-ied. This research evaluates in vitro synergistic activities of hydroalcoholic extracts. Phytochemical analysis confirmed presence flavonoids, tannins, polyphenols both Individually, they demonstrated significant ac-tivity (78.5% 72.3%,...
A total asymmetric synthesis of (−)-cephalotaxine is reported. The chemistry α,β-unsaturated γ-lactams was used to access the 1-azaspiro[4.4]nonane skeleton in enantiomerically pure form via a stereocontrolled semipinacolic rearrangement an α-hydroxyiminium ion. This spiro compound transformed into without any racemization or epimerization by following racemic reported Kuehne. We thus performed 98.7% ee with overall yield 9.8% over 16 steps sequence. synthetic process adaptable some...
Magnetic Resonance Imaging (MRI) using contrast agents is a very powerful technique for diagnosis in clinical medicine and biomedical research. The synthesis of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles targeting αvβ3 integrins acting as new MRI seems to be promising way cancer diagnosis. Indeed, it well established that integrin plays key role tumor angiogenesis like receptor the extracellular matrix proteins vitronectin, fibronectin through arginine-glycine-aspartic...
Abstract The general preparation of enantiopure monoacid side‐chains several esters cephalotaxine is described. strategy, similar to Weinreb's approach the synthesis deoxyharringtonine, used as key intermediate chiral nonracemic epoxide 11a prepared from commercially available monomethyl itaconate ( 8 ). step strategy was ring‐opening by using different organocuprate nucleophiles. Hydrogenolysis final gave monacid corresponding in moderate good overall yields .(© Wiley‐VCH Verlag GmbH &...
Background: Numerous natural products have been successfully developed for clinical use in the treatment of human diseases almost every therapeutic area. Objective: This work aimed to synthesize some new analogs Carlina oxide by functionalizing fifth position furan different acyl groups using Friedel-Crafts acylation approach. The synthetic and carlina were then assessed their in-vitro anti-inflammatory activity in-silico alpha-amylase inhibition effect. Methods: synthesized at room...
Various chiral α,β-unsaturated γ-lactams 1 were prepared in high yield and a single step from corresponding primary amines.The different reactivities of lactams could be exploited to prepare diversely substituted pyrrolidones, pyrrolidines, γ-aminoacids alkaloids.Their application the synthesis enantiomerically pure (-)-cephalotaxine are described.
Nowadays, developing effective antibiotics for bacterial control has become difficult due to increased resistance the available medicines in market. Essential oils possess interesting biological properties as some of their components have very powerful antiviral and antibacterial properties. Carthamus caeruleus is a plant that antioxidant activity presence an acetylenic compound, Carlina oxide. The aim this work was provide, first time, chemical modifications structure oxide insilico study...
An improved synthesis of unsaturated γ-lactams by condensation various primary amines with 2,5-dimethoxy-2,5-dihydrofuran is described. A modified mechanism for this reaction suggested. Synthesis their N-α-methoxylated derivatives, as N-acyliminium ion precursors, also reported. Finally, a short (±)-crispine presented an illustrative application.