A5077606912- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Graphite, nuclear technology, radiation studies
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Radiation Therapy and Dosimetry
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Nuclear and radioactivity studies
- Advanced MRI Techniques and Applications
- Bone health and treatments
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Cancer Diagnosis and Treatment
- Infrared Thermography in Medicine
- Neuroblastoma Research and Treatments
- MRI in cancer diagnosis
- Prostate Cancer Treatment and Research
- Body Composition Measurement Techniques
- Bone health and osteoporosis research
Istanbul University
2015-2025
Dokuz Eylül University
2020
Sağlık Bilimleri Üniversitesi
2020
Ege Üniversitesi Tıp Fakültesi Hastanesi
2020
Istanbul University-Cerrahpaşa
2020
Adli Tıp Kurumu
2020
Şişli Etfal Eğitim ve Araştırma Hastanesi
2020
Manisa Celal Bayar University
2020
Objectives This study is set out to estimate the radiation-absorbed doses normal organs and tumor tissue using low-dose 177 Lu-FAPI04 dosimetry determine safety theranostic potential of fibroblast activation protein–targeted radionuclide therapy. Patients Methods Four patients with metastatic advanced-stage cancer were administered for measurements. Data acquisition tumors was performed by whole-body 3D SPECT/CT imaging at 4, 24, 48, 96 hours after administering Lu-FAPI04. Blood samples...
Positron Emission Tomography/Computed Tomography (PET/CT) combines metabolic and anatomical information improving the precision accuracy of oncological diagnostics. The standardized uptake value (SUV) measures tumor metabolism, yet its is influenced by partial volume effect (PVE), impacting small lesion detection. This study aims to refine PVE corrections for lesions using an in-house customized, special anthropomorphic phantom. Scans this phantom which contained spheres different sizes were...
Abstract Purpose This study aimed to evaluate the personalized dosimetric approach by calculating cumulative renal absorbed dose (cRD) and assessing its impact on functions in patients diagnosed with metastatic castration-resistant prostate cancer who underwent four or more cycles of [ 177 Lu] Lu-PSMA − 617 therapy. Methods The included 110 received ≥ 4 Whole-body static abdominal SPECT-CT imaging was performed at 4, 24, 96 h post-administration. Kidney function assessed using dynamic...
The aim of this study is to create an inhomogeneous human-like phantom, whose attenuation and scattering effects are similar the human body, as alternative homogeneous phantoms traditionally used in calibration factor (CF) determination. phantom was designed include thorax, abdomen upper pelvis regions sized represent a 75-kg male with body mass index 25. Measurements using Lu-177 50- 100-mL lesion volumes were performed anthropomorphic (ABP) NEMA PET phantom. There difference 5.7%...
This study evaluated the effect of an increase in time interval between hepatic intra-arterial injection
Background Peptide receptor radionuclide therapy and selective internal radiation are effective modalities for unresectable metastatic neuroendocrine tumor patients that cannot be controlled with somatostatin analogs. The present study is intended to evaluate the therapeutic efficacy toxicity of combined peptide stand-alone in tumor, a liver-dominant disease. Methods This cohort consists 27 They were grouped as who treated liver metastasis (n = 15) received combination 12) hepatic...
Günümüzde tıp ve endüstri alanında yaygın olarak kullanılan iyonize radyasyon, canlı dokudan geçerken enerjisinin bir kısmını ya da tamamını dokuya aktarır.Canlı organizmada düşük maruziyet dozlarından yüksek dozlara dek olası zararlı etkilere neden olur.Bunlar stokastik etkiler (kanser, mutasyonlar) deterministik etkilerdir (yeni ismi doku reaksiyonları, dermatit, katarakt gibi).Radyasyon çalışanlarının halkın radyasyon maruziyetinin olabildiğince tutulması
Background: The aim of this study is to clarify the critical organs that limit treatment scheme and also evaluate validity currently used organ threshold values in neuroendocrine tumor (NET) patients, receiving peptide receptor radionuclide therapy (PRRT) with Lutetium 177 (177Lu)-DOTATATE. Materials Methods: Thirty-six NET patients (ages 16-73 years) who received 177Lu-DOTATATE were evaluated retrospectively study. Dosimetric calculations made using medical internal dose method. For...
Introduction: Lutetium-177 ( 177 Lu) prostate-specific membrane antigen (PSMA) was first applied for treating castration-resistant prostate cancer (CRPC) in 2015, and PSA changes, low side effects, good responses have been reported the literature.Dosimetric calculations are required to determine optimum number of treatments prevent damage critical organs.The aim this study retrospectively investigate feasibility dosimetric with fewer than four scans most imaging hours if can be performed...
Abstract Background Personalised multi-compartment dosimetry based on [ 99m Tc]Tc-MAA is a valuable tool for planning 90 Y radioembolization treatments. The establishment and effective application of dose–effect relationships in yttrium-90 ( Y) requires SPECT quantification ideally independent clinical site. purpose this multi-centre phantom study was to evaluate inter-site variability imaging standardised protocol. Data obtained from the TARGET study, an international, retrospective...
Accurate dosimetric calculations are essential to enhance therapeutic efficacy in Yttrium-90 (Y-90) microsphere therapy, which rely significantly on the three-dimensional imaging parameters used. This study aims evaluate reconstruction used generate images from SPECT data obtained for calculations, and determine optimal parameters. retrospective evaluated Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) of 30 patients (8 women 22 men) who underwent Transarterial...
Nuclear medicine is a discipline being used unsealed radioactive source in the diagnosis and treatment of disorders.Radiopharmaceuticals are administered directly into patient for or therapy disease.Thus, becomes radiation while.Protection from unnecessary exposure persons around essential.Effective doses patients people during frequent performed nuclear diagnostic tests reported previously published studies.It was aimed to present safety process related with who applied radiopharmaceuticals...
Sintigrafik görüntüler kullanıcıdan bağımsız doğru klinik bilgilerin elde edilmesini sağlayarak hastalıkların tanısında önemli rol oynar.Ancak, görüntüleme sisteminin performansındaki değişimler ve/veya dışarıdan kaynaklanan nedenlerle istenilen kalitede görüntü edilemeyebilir.Yeterli olmayan çalışmaların yorumlanmasını zorlaştıracaktır
Osteoporosis is the most common metabolic bone disease and can result in devastating physical, psychosocial, economic consequences. It occurs women after menopause affects elderly. Dual-energy x-ray absorptiometry (DXA) currently widely used method for measurement of areal Bone Mineral Density (BMD) (g/cm2) .DXA based on variable absorption X-ray by different body components uses high low energy photons. There are two important values assessment DXA. These T-score Z-score. The calculated...
Radyoaktif hastanın tıbbi durumunun bozulması durumunda acil hayat kurtarıcı prosedürlerin yapılması, personelin maruz kalacağı radyasyon maruziyetinden önce gelmelidir.Bu nedenle radyasyondan korunma görevlisinin tavsiyeleri hızlıca alınmalı ve önlemleri uygun olarak yerine getirilmelidir.Anahtar Kelimeler: hasta, durum,
Radyoaktif hastanın tıbbi durumunun bozulması durumunda acil hayat kurtarıcı prosedürlerin yapılması, personelin maruz kalacağı radyasyon maruziyetinden önce gelmelidir.Bu nedenle radyasyondan korunma görevlisinin tavsiyeleri hızlıca alınmalı ve önlemleri uygun olarak yerine getirilmelidir.Anahtar Kelimeler: hasta, durum,
The one of the aim nuclear medicine is diagnosis an abnormal metabolic activities in target organs. In a routine imaging procedure, radiopharmaceutical used. Radiopharmaceutical’s radionuclide part emits gamma radiation. This radiation dedected by Gamma Camera or Single Photon Emission Computed Tomography (SPECT). A computed tomography (CT) device was added to SPECT(SPECT- CT). To combine anatomical images. Image quality this important for accurate and treatment diseases. By means control...
Kalite kontrol (KK) uygulamaları, klinik çalışmalarda pozitron emisyon tomografi (PET) görüntüleme sistemlerinden elde edilen sonuçların güvenilirliği ve doğruluğu için önemlidir.Bu uygulamalar ile hasta çalışanların daha fazla radyasyona maruz kalmaları önlenecek kuruldukları zamana göre performanslarını kaybetmiş sistemlerin saptanması mümkün olacaktır