A5038985885- Pharmacological Receptor Mechanisms and Effects
- Free Radicals and Antioxidants
- Malaria Research and Control
- Complementary and Alternative Medicine Studies
- Receptor Mechanisms and Signaling
- Bioactive Compounds and Antitumor Agents
- Nitric Oxide and Endothelin Effects
- Attention Deficit Hyperactivity Disorder
- Eicosanoids and Hypertension Pharmacology
- Ethnobotanical and Medicinal Plants Studies
- Phytochemistry and Bioactivity Studies
- Sociology and Cultural Identity Studies
- Natural Compound Pharmacology Studies
- Sulfur Compounds in Biology
- Chemical Reaction Mechanisms
- Psychedelics and Drug Studies
- Chemical Synthesis and Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Marine Sponges and Natural Products
- Organic and Inorganic Chemical Reactions
- Tuberculosis Research and Epidemiology
- Organic and Molecular Conductors Research
- Globalization and Cultural Identity
- Psidium guajava Extracts and Applications
- Supramolecular Chemistry and Complexes
North-West University
2000-2019
Academy of Pharmaceutical Sciences
2016
Shandong Academy of Pharmaceutical Sciences
2016
Felician College
1993
Monoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary amines targets the treatment of neuropsychiatric neurodegenerative disorders. This study examined MAO inhibition potential kavain other kavalactones from roots kava (Piper methysticum), a plant that has been used its anxiolytic properties. (±)-Kavain was found to be good potency in vitro inhibitor human MAO-B with an IC50 5.34 µM. is weaker MAO-A 19.0 Under same experimental conditions, reference inhibitor,...
A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for calcium channel N-methyl-D-aspartate receptor modulating activity. The compounds classified into two groups, based on their moieties: unsaturated nitro (1, 2 3) esters, or nitrates (4, 5 6). obtained via the reaction hydroxyl functionalities with thionylchloride nitrate. All exhibited significant (p < 0.01) S-nitrosylation capacity. activity amines was evaluated using a KCl...
Identifying plant extracts as sources of antimalarial compounds needs to be addressed numerous studies screen without the means eliminating that are merely cytotoxic. Fifty-nine organic solvent from South African plants were screened for antiplasmodial activity using [3H]-hypoxanthine incorporation assay against chloroquine-resistant Plasmodium falciparum. Variable and toxicity was observed. Extracts form Combretum erythrophyllum Crinum bulbispermum, had IC50 values 1 mg/ml with ethyl...
Using a cyanide model to induce neurotoxic effects in rat brain homogenates, we examined the neuroprotective properties of three H3 antagonists, namely clobenpropit, thioperamide and impentamine, compared them aspirin, known agent. Superoxide anion levels malondialdehyde concentration were assessed using nitroblue tetrazolium lipid peroxidation assays. Clobenpropit significantly reduced superoxide generation peroxidation. Impentamine at all concentrations used, but only 1 mM. In assay, drugs...
Introduction: Recent research points to the Sigma Receptor (σR) as a possible neuromodulatory system with multi-functional action and σ 1 Rs have been suggested drug target for number of CNS conditions. Hexacyclododecylamines shown R activity provide an advantageous scaffold design that can improve blood-brain barrier permeability privileged structures. Methods Materials: A series oxa- aza- hexaxcyclododecylamines were synthesised evaluated sigma-1 receptor voltage-gated calcium channel...
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The biological activity of Gladiolus dalenii van Geel (Iridaceae) corms (used in ethnomedicine) and leaves were evaluated a few systems. A profile acute toxicity rats was compiled it found that both contained cytotoxic substances affecting mitotic active tissue. Acute deaths resulted from congestive heart failure. fraction (coded as GDI) isolated qualitatively similar to leaves. Estimated minimum lethal doses, given mg/kg body weight, lie the range 10-31 (i.p.) 3 160 - 5 620 (p.o.) for...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”