A5102739746- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Total Knee Arthroplasty Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Tendon Structure and Treatment
- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Lower Extremity Biomechanics and Pathologies
- Cell Adhesion Molecules Research
- Orthopedic Surgery and Rehabilitation
- Monoclonal and Polyclonal Antibodies Research
- Periodontal Regeneration and Treatments
- Inflammatory mediators and NSAID effects
- Nerve Injury and Rehabilitation
- Nasal Surgery and Airway Studies
- Intramuscular injections and effects
- Surgical Sutures and Adhesives
- Veterinary Equine Medical Research
- Ear Surgery and Otitis Media
- Sports injuries and prevention
Instituto Nacional de Rehabilitación
2014-2023
Hospital Médica Sur
2021-2023
Hospital for Special Surgery
1998-2022
Secretaria de Salud
2011-2015
National Rehabilitation Center
2015
Tecnológico Nacional de México
2014
Instituto Politécnico Nacional
2014
Universidad Nacional Autónoma de México
2012
Servicio Gallego de Salud
2010
University of Massachusetts Chan Medical School
1996-2003
Abstract New cartilage formation has been successfully achieved by a technology referred to as tissue engineering. Polymers and hydrogels such poly(glycolic acid), calcium alginate, poly(ethylene) poly(propylene) have used cell carriers regenerate in the nude mouse model. The next step toward human applications of engineered is demonstrate their potential immunocompetent animal models. This study compared suitability three polymers for generating elastic using autologous cells an...
In the repair of cartilage defects, autologous tissue offers advantage lasting biocompatibility. The ability bovine chondrocytes isolated from hyaline to generate tissue-engineered in a predetermined shape, such as human ear, has been demonstrated; however, potential elastic remains unknown. this study, authors examined multiplication characteristics auricular and these cells new function length time they are maintained vitro. Human cartilage, harvested patients 5 17 years age, was digested...
The development and characterization of a hybrid hydrogel based on chitosan (CS) poly(vinyl alcohol) (PVA) chemically cross-linked with epichlorohydrin (ECH) is presented. mechanical response these hydrogels was evaluated by uniaxial tensile tests; in addition, their structural properties such as average molecular weight between cross-link points (Mcrl), mesh size (DN), volume fraction (vs) were determined. This done using the equivalent polymer network theory combination obtained results...
Ingrowth of host blood vessels into engineered tissues has potential benefits for successful transplantation as well healing surrounding tissues. In particular, the use a vascularized bioengineered tissue could be beneficial treating injuries to meniscus, structure in knee where lack vascular supply is associated with an inadequate response. this study, gene transfer using adenovirus vector encoding hepatocyte growth factor (AdHGF) was used induce vessel formation tissue-engineered meniscus....
Background: Few randomized controlled trials with a midterm follow-up have compared matrix-assisted autologous chondrocyte transplantation (MACT) microfracture (MFx) for knee cartilage lesions. Purpose: To compare the structural, clinical, and safety outcomes at of MACT versus MFx treating symptomatic Study Design: Randomized trial; Level evidence, 1. Methods: A total 48 patients aged between 18 50 years, 1- to 4-cm 2 International Cartilage Repair Society (ICRS) grade III IV chondral...
In the repair of cartilage defects, autologous tissue offers advantage lasting biocompatibility. The ability bovine chondrocytes isolated from hyaline to generate tissue-engineered in a predetermined shape, such as human ear, has been demonstrated; however, potential elastic remains unknown. this study, authors examined multiplication characteristics auricular and these cells new function length time they are maintained vitro. Human cartilage, harvested patients 5 17 years age, was digested...
Hallmarks of the pathogenesis rotator cuff disease (RCD) include an abnormal immune response, angiogenesis, and altered variables vascularity. Degenerative changes enhance production pro-inflammatory, anti-inflammatory, vascular angiogenesis-related cytokines (ARC) that play a pivotal role in response to arthroscopic surgery participate RCD. The purpose this study was evaluate ARC profile, ie, interleukin (IL): IL-1β, IL-6, IL-8, IL-10, endothelial growth factor (VEGF), basic fibroblast...
Tissue engineering has been used for the treatment of several skin diseases and lesions; however, tissue regenerative medicine also have a huge potential in cosmetology. They include substitutes, cell therapy wound-healing treatments based on biomaterial-based replacements 3D systems. This review focuses bioprinting technology how it can improve functions, restoring pigmentation or helping hair follicles to develop.
Background Complex meniscal lesions often require meniscectomy with favorable results in the short term but a high risk of early osteoarthritis subsequently. Partial treated substitutes may delay articular cartilage degeneration. Purpose To evaluate status by T2 mapping after substitution polyurethane scaffolds enriched mesenchymal stem cells (MSC) and comparison acellular at 12 months. Methods Seventeen patients (18-50 years) past meniscectomies were enrolled 2 groups: (1) scaffold (APS) or...
The Integrin β1 family is the major receptors of Extracellular matrix (ECM), and synthesis degradation balance ECM seriously disrupted during Osteoarthritis (OA). In this scenario, integrins modify their pattern expression regulate chondrocyte differentiation in articular cartilage. Members Transforming growth factor beta (Tgf-β) Superfamily, such as Growth 5 (Gdf-5) Bone morphogenetic protein 7 (Bmp-7), play a key role joint formation could integrin osteoarthritis progression an...
Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing often affected by bacterial infection; where biofilm formation one the main risks particularly problematic because it confers protection to microorganisms against antibiotics. One avenue prevent colonization use silver nanoparticles (AgNPs); which have proved be effective non-multidrug-resistant multidrug-resistant bacteria. In addition, mesenchymal...
Human adipose-derived mesenchymal stem cells (hADMSCs) are believed to be potential key factors for starting the regenerative process after tissue injury. However, an efficient method of delivering these external wound site is still lacking. amnion and pig skin have long been used as dressings treatment burns other lesions. Herein, we present generation two constructs using biomaterials effective scaffolds culture hADMSCs. It was found that hADMSCs seeded onto radiosterilized human viable...
This work describes the preparation and characterization of biomimetic chitosan/multiwall carbon nanotubes/nano-hydroxyapatite (CTS/MWCNT/nHAp) scaffolds their viability for bone tissue engineering applications. The cryogenic process ice segregation-induced self-assembly (ISISA) was used to fabricate 3D CTS scaffolds. Proper combination cryogenics, freeze-drying, nature molecular ratio solutes give rise porous interconnected with clusters nHAp distributed along scaffold surface. effect...
Blends of natural and synthetic polymers have recently attracted great attention as scaffolds for tissue engineering applications due to their favorable biological mechanical properties. Nevertheless, phase-separation blend components is an important challenge facing the development electrospun homogeneous fibrillar natural-synthetic scaffolds; can produce significant detrimental effects fabricated by electrospinning. In present study, blends gelatin (Gel; polymer) polycaprolactone (PCL;...