A5047649647- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Nanoparticles: synthesis and applications
- Silk-based biomaterials and applications
- Advanced Sensor and Energy Harvesting Materials
- Bone Tissue Engineering Materials
- Nanocomposite Films for Food Packaging
- Graphene and Nanomaterials Applications
- Osteoarthritis Treatment and Mechanisms
- Conducting polymers and applications
- Microbial bioremediation and biosurfactants
- Biotechnology and Related Fields
- Wound Healing and Treatments
- biodegradable polymer synthesis and properties
- Advanced Drug Delivery Systems
- Carbon Nanotubes in Composites
- Periodontal Regeneration and Treatments
- Nanoparticle-Based Drug Delivery
- Business, Innovation, and Economy
- Probiotics and Fermented Foods
- Pickering emulsions and particle stabilization
- Anodic Oxide Films and Nanostructures
- Educational Research and Science Teaching
- Microbial Fuel Cells and Bioremediation
Secretaría de Salud de Jalisco
2016-2025
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco
2016-2025
Universidad Nacional Autónoma de México
2009-2024
Pharmaceutical Biotechnology (Czechia)
2018
Instituto Nacional de Rehabilitación
2009-2015
Center for Research and Advanced Studies of the National Polytechnic Institute
2009-2013
Instituto de Ciencia de Materiales de Sevilla
2007
Instituto de Ciencia de Materiales de Madrid
2006-2007
Consejo Superior de Investigaciones Científicas
2006-2007
Centro Nacional de Biotecnología
2006
Abstract Poly(vinyl alcohol) (PVA) scaffolds are prepared by a cryogenic process that consists of the unidirectional freezing PVA solution. The exhibit microchanneled structure, morphology which (in terms pore diameter, surface area, and thickness matter accumulated between adjacent microchannels) can be finely tailored averaged molecular weight PVA, concentration in solution, rate resulting suitable substrates for drug‐delivery purposes, drug release being controlled (from tens minutes up...
Three-dimensional (3D) hydrogels provide tissue-like complexities and allow for the spatial orientation of cells, leading to more realistic cellular responses in pathophysiological environments. There is a growing interest developing multifunctional using ternary mixtures biomedical applications. This study examined biocompatibility suitability human auricular chondrocytes from microtia cultured onto steam-sterilized 3D Chitosan/Gelatin/Poly(Vinyl Alcohol) (CS/Gel/PVA) as scaffolds tissue...
ABSTRACT Gelatin/chitosan/poly(vinyl alcohol) (PVA) hydrogels were fabricated with different polymer ratio using the freeze‐drying process. The thermal stability, water state, rheological, and cytotoxic properties of evaluated. Thermogravimetric/differential scanning calorimetry analyses showed a decomposition onset temperature below 242.7 ± 2.7 °C. samples did not show statistical differences ( p < 0.05) on values. Nonfreezing reached constant value around 1 g water/g polymer. Freezing...
Abstract BACKGROUND Hydrogels are materials with great potential in agricultural applications. Biodegradable hydrogels used as preparations, for example to increase the substratum water capacity, and improve soil structure or agrochemical‐controlled release. This work aimed develop biodegradable based on chitosan, gelatin polyvinyl alcohol (PVA) releasing inulin isolated from Dahlia tubers induce protection chili plants against Phytophthora capsici . The were characterized by absorption...
Ultralightweight (specific gravity 8.0 × 10–2) and highly conductive (1.4 S cm–1) MWCNT scaffolds exhibited remarkable biocompatibility for E. coli which allows bacteria immobilization proliferation within its microchanneled structure. The above-mentioned features make these potentially useful as electrodes in microbial fuel cells (MFCs).
The development and characterization of a hybrid hydrogel based on chitosan (CS) poly(vinyl alcohol) (PVA) chemically cross-linked with epichlorohydrin (ECH) is presented. mechanical response these hydrogels was evaluated by uniaxial tensile tests; in addition, their structural properties such as average molecular weight between cross-link points (Mcrl), mesh size (DN), volume fraction (vs) were determined. This done using the equivalent polymer network theory combination obtained results...
Biocompatibility is an important issue that still needs research if one desires to fully preserve the metabolic activity of cells encapsulated in any type material. Spectroscopic techniques (e.g., NMR and fluorescence) have been used study viability decrease upon aging time bacteria silica gel materials. Unfortunately, none these spectroscopic are able provide insights about detrimental causes affecting cells. The current work uses cryo-scanning electron microscopy (cryo-SEM) for situ...
Gelatin/chitosan/polyvinyl alcohol hydrogels were fabricated at different polymer ratios using the freeze-drying and sterilized by steam sterilization. The thermal stability, chemical structure, morphology, surface area, mechanical properties, biocompatibility of evaluated simultaneous analysis, Fourier transform infrared spectroscopy, X-ray diffraction, confocal microscopy, adsorption/desorption nitrogen, rheometry, 3-4,[5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide cell...
We have studied the suitability of a cryogenic process (e.g., ice-segregation-induced self-assembly, ISISA) for preparation polyvinyl alcohol (PVA) scaffolds with in situ immobilized bacteria Escherichia coli). Confocal fluorescence microscopy and impedance measurements were used to evaluate extension proliferation within scaffold macrostructure. The efficiency colonization macrostructure is compared without use additional cryoprotectans. Cryoprotection by entrapment alginate beads...
Abstract Porous silicon (PS) has been widely used in biology, biomedicine, and nanotechnology. In recent years, its application cancer therapy received considerable attention. PS shown low cytotoxicity, so it is reasonable to use as an antibody conjugate for targeted anticancer drug delivery. this work, we synthesized covalently attached doxorubicin covered by a nanometric polymer crosslinker between the monoclonal trastuzumab, using electrochemical etching particle generation. The results...
The (CTS- g -GMA)-X hydrogels showed higher viability in keratinocytes and nerve cells than the control (glass) pure chitosan. No diseases were detected human cells, as protein markers no abnormalities.
This work describes the preparation and characterization of biomimetic chitosan/multiwall carbon nanotubes/nano-hydroxyapatite (CTS/MWCNT/nHAp) scaffolds their viability for bone tissue engineering applications. The cryogenic process ice segregation-induced self-assembly (ISISA) was used to fabricate 3D CTS scaffolds. Proper combination cryogenics, freeze-drying, nature molecular ratio solutes give rise porous interconnected with clusters nHAp distributed along scaffold surface. effect...
Probiotic bacteria are widely used to prepare pharmaceutical products and functional foods because they promote sustain health. Nonetheless, probiotic viability is prone decrease under gastrointestinal conditions. In this investigation, Lactiplantibacillus plantarum spp. CM-CNRG TB98 was entrapped in a gelatin−poly (vinyl alcohol) (Gel−PVA) hydrogel which prepared by “green” route using microbial transglutaminase (mTGase), acts as crosslinking agent. The fully characterized its ability...
Tissue engineering with the use of biodegradable and biocompatible scaffolds is an interesting option for ear repair. Chitosan-Polyvinyl alcohol-Epichlorohydrine hydrogel (CS-PVA-ECH) displays appropriate mechanical properties to be used as a scaffold. The present work, studies potential CS-PVA-ECH seeded chondrocytes develop elastic cartilage engineered-neotissues. Chondrocytes isolated from rabbit swine were independently cultured onto 20 days form constructs. Then, in vitro cell viability...
Abstract The molecular dynamics of poly(vinyl alcohol) (PVA) were studied by dielectric spectroscopy and dynamic mechanical analysis in the 20–300°C range. well‐established plasticizing effect water on glass‐transition temperature ( T g ) PVA was revisited. Improper elimination has led to a misinterpretation thermal relaxations such that depressed for wet films (ca. 40°C) been assigned as secondary β relaxation number previous studies literature. In samples, two different...
The design of drug nanocarriers is a topic current interest. To achieve desirable efficiency, the preparation new nanocarrier must tune multiple complicated factors. Polyethylene glycol (PEG) has demonstrated ability to evade biological barriers living matter. In this work, synthesis nanocomposites prepared with PEG and carbon nanotubes (CNTs) functionalized amine ending groups (named CNTsamine), which could be used as described. A thorough characterization using Fourier transform infrared...
Tissue engineering (TE) has become an alternative for auricular reconstruction based on the combination of cells, molecular signals and biomaterials.Scaffolds are biomaterials that provide structural support cell attachment subsequent tissue development.Ideally, a scaffold should have characteristics such as biocompatibility bioactivity to adequate functions.Our purpose was evaluate microtic chondrocytes seeded onto chitosan-polyvinyl alcohol-epichlorohydrin (CS-PVA-ECH) hydrogel propose...
Cell spheroids are an important three-dimensional (3D) model for in vitro testing and gaining interest their use clinical applications. More natural 3D cell culture environments that support cell–cell interactions have been created cancer drug discovery therapy applications, such as the scaffold-free Petri Dish® technology. This technology uses reusable autoclavable silicone micro-molds with different topographies, it conventionally gelled agarose hydrogel formation to preserve topography of...
Cross-linked polymer blends from natural compounds, namely gelatin (Gel), chitosan (CS), and synthetic poly (vinyl alcohol) (PVA), have received increasing scrutiny because of their versatility, biocompatibility, ease use for tissue engineering. Previously, Gel/CS/PVA [1:1:1] hydrogel produced via the freeze-drying process presented enhanced mechanical properties. This study aimed to investigate biocompatibility chondrogenic potential a steam-sterilized using differentiation human...