A5035278550- Pregnancy and Medication Impact
- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Reproductive System and Pregnancy
- Microscopic Colitis
- Esophageal and GI Pathology
- Gastrointestinal motility and disorders
- Neonatal Respiratory Health Research
- Gut microbiota and health
- Celiac Disease Research and Management
- Appendicitis Diagnosis and Management
- Congenital Anomalies and Fetal Surgery
- Intestinal Malrotation and Obstruction Disorders
- Pregnancy and preeclampsia studies
- Hepatitis B Virus Studies
- Biomedical Ethics and Regulation
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Impact on Reproduction
- Dysphagia Assessment and Management
- Ethics in Clinical Research
- Adolescent and Pediatric Healthcare
- Viral Infections and Immunology Research
- Birth, Development, and Health
- Human Health and Disease
- Systemic Lupus Erythematosus Research
Erasmus MC
2013-2020
Erasmus University Rotterdam
2014-2018
<h3>Objective</h3> Antitumour necrosis factor (TNF) during pregnancy in patients with IBD is related to high fetal anti-TNF levels. We evaluated maternal and child safety on discontinuing the second trimester of pregnancy. <h3>Design</h3> Two groups women were prospectively followed-up pregnancy: sustained remission stopped before week 25 (stop group) remaining group continued beyond 30 (continue group). Maternal, birth 1-year outcomes compared children non-IBD women. <h3>Results</h3>...
Around 30% of patients with inflammatory bowel disease (IBD) are refractory to current IBD drugs or relapse over time. Novel treatments called for, and low dose Naltrexone (LDN) may provide a safe, easily accessible alternative treatment option for these patients. We investigated the potential LDN induce clinical response in therapy patients, its direct effects on epithelial barrier function. Patients not remission responding conventional were offered initiate as concomitant treatment. In...
Objective The aim of this study was to describe the long-term health outcomes children born mothers with inflammatory bowel disease (IBD) and assess impact maternal IBD medication use on these outcomes. Design We performed a multicentre retrospective in Netherlands. Women who gave birth between 1999 2018 were enrolled from 20 participating hospitals. Information regarding characteristics, use, lifestyle, pregnancy retrieved medical charts. After consent both parents, until 5 years also...
Women with inflammatory bowel disease [IBD] have a higher risk of undergoing gastrointestinal [GI] endoscopy during pregnancy than healthy women. Data on endoscopic procedures in IBD women are limited. The aim this study was to investigate the safety lower GI women.All consecutive who underwent [cases] from 2008-2014 were prospectively included. Cases matched 1:1 age, medication, and activity pregnant patients without [controls]. Maternal neonatal outcomes compared between cases controls....
Neonates exposed to tumour necrosis factor [TNF] alpha inhibitors in utero are born with detectable drug levels which can still be detected throughout the first year of life. Since 2011, hepatitis B virus [HBV] vaccine is routinely administered all newborns Netherlands. Adults treated anti-TNF have been reported respond inadequately HBV vaccine. The aim this study was compare anti-HB anti-TNF-exposed children non-exposed following routine Dutch vaccination.We performed a cross-sectional,...
Background: The ECCO pregnancy guideline provides recommendations regarding anti-TNF treatment during that apply to all types. However, in our prospective cohort we found women using adalimumab (ADA) had lower drug levels cord blood than infliximab (IFX). We aimed develop a stopping model for can be used clinical practice. Methods: Women with IBD were prospectively enrolled at preconception outpatient clinic from Dec '08 until Jul '16 and counseled according the guideline. During bimonthly...
Background/Aims: An altered intestinal microbial composition (dysbiosis) is associated with inflammation in inflammatory bowel disease, which are characterized by decreased bacterial diversity and an ratio of beneficial aggressive species. We analyzed profiles feces mucosal tissues from Korean diseases (IBD) patients healthy controls (HC) using high-throughput sequencing method. Methods: Fecal or tissue DNA were isolated 35 Crohn's disease (CD) patients, 20 ulcerative colitis (UC) 31 HC....
Clinical: Therapy & observation S301 rate in the late-onset group tended to be lower than that early-onset group.In particular, resection was significantly patients with perforating type (12.5%) compared (21.3%).(3) Multivariate analysis revealed absence of anti-TNF-a therapy a sole risk factor for surgery.(4) The cumulative over 5 years receiving those not this therapy, based on background-matched between 2 groups (30.0% vs. 17.7%).In addition, early initiation (within 3 disease onset)...
Results: During 131 million person years of observation, 21 CD patients developed small bowel adenocarcinomas in the ileum or jejunum resulting a 23-fold increased risk (SIR 23.5, 95% CI: 14.6 36.0).Nine carcinoid tumours 6-fold 6.6, 3.0 12.5).CD were not at sarcomas, nor with ulcerative colitis SBCs.Of associated severe inflammation was found 13 (62%), moderate 3 (14%), mild 2 (10%), and 1 (5%) case remission.Conclusions: This is hitherto largest population-based study evaluating SBC IBD,...