The realization of microscale total analysis systems and lab-on-a-chip technologies requires efficient actuation (mixing, pumping, atomizing, nebulizing, driving, etc.) fluids on the microscopic scale dexterous manipulation (separation, sorting, trapping, concentration, merging, patterning, aligning, focusing, micro-objects (cells, droplets, particles, nanotubes, in open (sessile droplets) as well confined spaces (microchannels/chambers). These capabilities have been recently achieved using...

We demonstrate a simple and efficient device for the continuous label-free separation of microparticles using travelling surface acoustic waves (TSAW). A focusing interdigitated unidirectional transducer released high frequency (133.3 MHz) TSAW normal to fluid flow direction segregate 3 μm particles from 10 with efficiency 100%. The based separator does not necessitate tight alignment PDMS microchannel transducer.

In this study, we have investigated the motion of polystyrene microparticles inside a sessile droplet water actuated by surface acoustic waves (SAWs), which produce an streaming flow (ASF) and impart radiation force (ARF) on particles. We categorized four distinct regimes (R1-R4) particle aggregation that depend diameter, SAW frequency, wave field (travelling or standing), waves' attenuation length, volume. The particles are concentrated at centre in form bead (R1), around periphery ring...

Submicron separation is the segregation of particles having a diameter difference less than one micrometre. We present an acoustofluidic particle separator with submicron resolution to study continuous, label-free, and contactless polystyrene (PS) based on their parameters such as size, density, compressibility shape. In this work, PS microspheres, marginal size difference, achieved inside polydimethylsiloxane (PDMS) microfluidic channel via travelling surface acoustic waves (TSAWs). The...

We demonstrate a miniaturized acoustofluidic device composed of pair slanted interdigitated transducers (SIDTs) and polydimethylsiloxane microchannel for achieving size-selective separation exchange medium around polystyrene particles in continuous, label-free, contactless fashion. The SIDTs, deposited parallel to each other, produce tunable traveling surface acoustic waves (TSAWs) at desired locations, which, turn, yield an anechoic corner inside the that is used selectively deflect choice...

We demonstrated the operation of an acoustomicrofluidic device composed a polydimethylsiloxane (PDMS) microchannel and slanted-finger interdigitated transducer (SF-IDT), for on-demand splitting droplets in active, accurate, rapid, size-controllable manner.

We demonstrate a simple device to generate chemical concentration gradients in microfluidic channel using focused travelling surface acoustic waves (F-TSAW). A pair of curved interdigitated metal electrodes deposited on the piezoelectric (LiNbO3) substrate disseminate high frequency sound when actuated by an alternating current source. The F-TSAW produces chaotic streaming flow upon its interaction with fluid inside channel, which mixes confluent streams chemicals controlled fashion for...

Abstract We report an observation of rapid (exceeding 2,000 K/s) heating polydimethylsiloxane (PDMS), one the most popular microchannel materials, under cyclic loadings at high (~MHz) frequencies. A microheater was developed based on finding. The mechanism utilized vibration damping in PDMS induced by sound waves that were generated and precisely controlled using a conventional surface acoustic wave (SAW) microfluidic system. refraction SAW into microchip, called leaky SAW, takes form bulk...

On-chip droplet splitting is one of the fundamental droplet-based microfluidic unit operations to control volume after production and increase operational capability, flexibility, throughput. Various methods have been proposed, among them acoustic method promising because its label-free operation without any physical or thermal damage droplets. Previous faced several limitations: first, they employed a cross-type acoustofluidic device that precluded multichannel splitting; second, required...

Acoustothermal tweezer system composed of an acoustothermal heater and a disposable PDMS microchannel is proposed as droplet sorting platform capable bidirectional multichannel sorting.

The realization of efficient mixing samples inside a microfluidic channel is essential for performing numerous biological assays in miniaturized total analysis systems. low Reynolds number flows at the microscale create laminar streams microchannel, limiting flow to molecular diffusion level. In this paper, we propose simple and acoustofluidic technique single-layered polydimethylsiloxane (PDMS) channel. proposed surface acoustic wave (SAW)-based system composed straight interdigitated...

Sheathless focusing and separation of microparticles is an important preprocessing step in various biochemical assays which enriched sample isolation critical. Most the previous microfluidic particle techniques have used sheath flows to achieve efficient focusing. The flow dilutes analyte requires additional microchannels accurate control. We demonstrated a tilted-angle traveling surface acoustic wave (taTSAW)-based sheathless particles continuous flow. proposed device consists piezoelectric...

We demonstrate an acoustofluidic device using Lamb waves (LWs) to manipulate polystyrene (PS) microparticles suspended in a sessile droplet of water. The LW-based platform used this study is advantageous that the actuated over range frequencies without changing structure or electrode pattern. In addition, simple operate and cheap fabricate. LWs, produced on piezoelectric substrate, attenuate inside fluid create acoustic streaming flow (ASF) form poloidal with toroidal vortices. PS particles...

A sessile droplet of water carrying polystyrene microparticles different diameters was uniformly exposed to high frequency surface acoustic waves (SAWs) produced by an interdigitated transducer (IDT). We investigated the concentration behavior as SAWs generated a strong streaming flow (ASF) inside and exerted direct radiation force (ARF) on suspended particles, magnitude which depended upon particle diameter. As result ARF, were concentrated according their at positions placed in path SAW,...

An acoustofluidic device for in-droplet microparticle washing and enrichment.

Size-independent separation of particles is performed using difference in acoustic impedances <italic>via</italic> travelling surface waves.

Abstract A particle suspended in a fluid within microfluidic channel experiences direct acoustic radiation force (ARF) when traveling surface waves (TSAWs) couple with the at Rayleigh angle, thus producing two components of ARF. Most SAW‐based devices rely on horizontal component ARF to migrate prefocused particles laterally across microchannel width. Although magnitude vertical is more than twice component, it long ignored due polydimethylsiloxane (PDMS) fabrication limitations and...

Engineering inertial lift forces and elastic is explored to transfer microparticles across laminar streams from non-Newtonian Newtonian fluid. A co-stream of flow loaded with (9.9 2.0 μm in diameter) a carrier medium straight rectangular conduit devised. The present the fluid, undeterred by particle–particle interaction, successfully pass most larger μm) particles over fluid takes focus them on equilibrium position, separating smaller particles. This mechanism enabled processing densely...

We demonstrate an acoustofluidic platform that uses surface acoustic waves (SAWs) for the facile capture of droplets inside microwells and their on-demand release. When ac signal applied to device is tuned modulate location SAW, SAW-based radiation force retracts or pushes into out one three fabricated a microchannel selectively release droplet.

Uniform fluid compartments are formed inside shape-coded amphiphilic particles using simple exchange steps. This lab on a particle system enables multiplexed enzymatic reactions without cross talk to democratize cutting-edge biological assays.

An acoustofluidic device to generate droplets with tunable chemical concentrations.

Abstract Crescent‐shaped hydrogel microparticles are shown to template uniform volume aqueous droplets upon simple mixing with and oil media for various bioassays. This emerging “lab on a particle” technique requires particles tunable material properties dimensions. The crescent shape of the is attained by two‐phase separation polymers followed photopolymerization curable precursor. In this work, phase poly(ethylene glycol) diacrylate (PEGDA, M w 700) dextran ( 40 000) manufacturing...