A5069367103- RNA Research and Splicing
- Nuclear Structure and Function
- Nutrition and Health in Aging
- Mesenchymal stem cell research
- Bone health and osteoporosis research
- Hemophilia Treatment and Research
- Frailty in Older Adults
- Bone and Joint Diseases
- Bone fractures and treatments
- Skin and Cellular Biology Research
- Virus-based gene therapy research
- Bone health and treatments
- Bone Metabolism and Diseases
- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Biochemical Acid Research Studies
- Peroxisome Proliferator-Activated Receptors
- Agricultural and Food Production Studies
- Cellular transport and secretion
- RNA regulation and disease
- Organ Donation and Transplantation
- Bone and Dental Protein Studies
- Cancer, Hypoxia, and Metabolism
- Connective tissue disorders research
- Body Composition Measurement Techniques
Universidad Simón Bolívar
2017-2019
Nepean Hospital
2012-2019
The University of Sydney
2012-2019
Universidad Surcolombiana
2009-2010
Abstract Infiltration of bone marrow with fat is a prevalent feature in people age-related loss and osteoporosis, which correlates inversely formation positively high expression levels peroxisomal proliferator-activated receptor gamma (PPARγ). Inhibition PPARγ thus represents potential therapeutic approach for loss. In this study, we examined the effect inhibition on skeletally mature C57BL/6 male mice. Nine-month-old mice were treated antagonist, bisphenol-A-diglycidyl ether (BADGE), alone...
ABSTRACT Changes in the expression of lamin A/C, a fibrilar protein nuclear envelope, are associated with cellular features age‐related bone loss. Reduced A/C inhibits osteoblastogenesis while facilitating adipogenic differentiation mesenchymal stem cells (MSC) vitro and vivo. In this study we investigated regulatory role that plays on essential elements Wnt/β‐catenin pathway, which pivotal MSC differentiation. Initially, assessed effect gene ( LMNA ) overexpression compared it to depleted...
Interferon gamma (IFNγ) has been reported to induce osteoblastogenesis from mesenchymal stem cells (MSCs) both in vitro and vivo. With ageing, adipocytes outnumber osteoblasts within the bone microenvironment leading a decrease formation. Since are of origin, we hypothesized that IFNγ treatment might negatively affect adipogenesis while stimulating human MSC. To test this hypothesis, MSCs were induced differentiate into presence or absence osteogenic doses (1, 10, 100 ng/ml). IFNγ-treated...
Circulating osteogenic progenitor (COP) cells are considered as surrogates of the mesenchymal repository in body. In this study, we hypothesized that COP decrease with age and lower levels associated greater frailty disability older persons. Using well-established clinical criteria, quantified physical performance stratified a random sample community-dwelling individuals enrolled Nepean Osteoporosis Frailty (NOF) Study (mean 82.8; N = 77; 70% female; 27 nonfrail, 23 prefrail, frail)....
Background: Use of antidepressant medications has been linked to detrimental impacts on bone mineral density and osteoporosis; however, the cellular basis behind these observations remains poorly understood.The effect does not appear be homogeneous across whole class drugs may affinity for serotonin transporter system.In this study, we hypothesized that antidepressants have a class-and dosedependent mesenchymal stem cell (MSC) differentiation, which affect metabolism.Methods: Human MSCs...
We have generated an Atp7a conditional knock in mouse model of dHMNX expressing<italic>Atp7a</italic><sup>T985I</sup>, the orthologue human<italic>ATP7A</italic><sup>T994I</sup>identified patients.
Realizar la descripción genética (frecuencias génicas [FG], genotípicas y haplotípicas) del sistema HLA (Human Leukocyte Antigen) en una población resulta de gran relevancia porque este conocimiento tiene implicaciones áreas ciencia como antropología (migración, mestizaje, etc.), los trasplantes, transfusión plaquetas, las enfermedades, forense, desarrollo vacunas nueva generación, entre otras. Al finalizar investigación que se determinan frecuencias o otro tipo, éstas deben comparar con...
ABSTRACT Mutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism this pro‐osteogenic phenotype remains unknown. We increased and decreased MAN1 expression mesenchymal stem cells (MSC) upon which standard osteogenic adipogenic differentiation were performed. knockdown osteogenesis mineralization. In contrast, remained stable overexpression. Regarding mechanism, we found that low levels facilitated accumulation regulatory smads...
Debido a la desinformación y mitificación que se ha acumulado durante muchos años en el ámbito de los trasplantes órganos, existe mundo una proporción inversa número pacientes lista espera donantes efectivos. Algunos países desarrollo han hecho esfuerzos investigativos maniobras legislativas para cambiar esas cifras, pero resultados no son significativos. Se presentan esta revisión hechos más importantes marcado éxito nuestro país, también algunas definiciones leyes rigen procedimiento,...