A5087330860- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Evolutionary Psychology and Human Behavior
- Infant Health and Development
- Autism Spectrum Disorder Research
- Prenatal Substance Exposure Effects
- Birth, Development, and Health
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Tryptophan and brain disorders
- Diet and metabolism studies
- Hedgehog Signaling Pathway Studies
- Genetic and rare skin diseases.
- Folate and B Vitamins Research
- Prion Diseases and Protein Misfolding
- Congenital limb and hand anomalies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bipolar Disorder and Treatment
- Genetic Syndromes and Imprinting
University of Chicago
2008-2022
Mountain Area Health Education Center
2020
Indiana University School of Medicine
2013-2016
University of North Carolina at Chapel Hill
2012-2016
New York State Office for People With Developmental Disabilities
2012
Rosalind Franklin University of Medicine and Science
2001-2003
NorthShore University HealthSystem
2002
Franklin University
2001
Genetic evidence predicts a causative role for amyloid-β (Aβ) in Alzheimer's disease. Recent debate has focused on whether fibrils (amyloid) or soluble oligomers of Aβ are the active species that contribute to neurodegeneration and dementia. We developed two aggregation protocols consistent production stable oligomeric fibrillar preparations Aβ-(1–42). Here we report inhibit neuronal viability 10-fold more than ∼40-fold unaggregated peptide, with Aβ-(1–42)-induced inhibition significant at...
Social deficits are a hallmark feature of autism spectrum disorder (ASD) and related developmental syndromes. Although there is no standard treatment for social dysfunction, clinical studies have identified oxytocin as potential therapeutic with prosocial efficacy. We previously reported that peripheral can increase sociability ameliorate repetitive stereotypy in adolescent mice from the C58/J model ASD-like behavior. In present study, we determined effects were not limited to period, since...
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is known to contribute the expression of psychostimulant sensitization by regulating dopamine (DA) overflow from DA neuron terminals in nucleus accumbens (NAcc). The present experiments explored contribution CaMKII NAcc neurons postsynaptic these where it participate a number signaling pathways that regulate responding drugs. Exposure amphetamine transiently increased alphaCaMKII levels shell but not core NAcc. Thus, HSV (herpes simplex...
Background The first trimester of human development and the equivalent developmental period in animal models is a time when teratogenic ethanol (EtOH) exposure induces major structural birth defects that fall within fetal alcohol spectrum disorder (FASD). Previous FASD research employing an acute high dose maternal intraperitoneal EtOH treatment paradigm has identified sensitive periods for number these defects. Extending this work, investigation utilized resolution magnetic resonance...
Abstract Dopaminergic projections from the ventral tegmental area ( VTA ) to nucleus accumbens NA cc) mediate behavioral and motivational effects of many drugs abuse, including nicotine. Repeated intermittent administration these drugs, a pattern often associated with initial drug exposure, sensitises reactivity dopamine DA neurons in this pathway, enhances locomotor behaviors emit, promotes their pursuit self‐administration. Here we show that activation nicotinic acetylcholine receptors (n...
Mice with knockdown of the N-methyl-<smlcap>d</smlcap>-aspartate (NMDA) receptor NR1 subunit, encoded by gene <i>Grin1,</i> have been investigated as a model for intrinsic NMDA hypofunction hypothesized schizophrenia. Previous work has shown that adult <i>Grin1</i> mutant mice overt deficits in habituation and sensorimotor gating, exaggerated reactivity to environmental stimuli, reduced social approach, other alterations reflect behavioral manifestations...
While pharmacological activation of the Hedgehog (HH) signaling pathway may have therapeutic benefits for developmental and adult diseases, its teratogenic potential is concern. The membrane molecule Smoothened (SMO) transduces HH can be acutely modulated by antagonists agonists. objective current experiments was to determine how maternal treatment with Smo agonist, SAG, affects developing limb.Pregnant C57BL/6J mice received a single injection SAG (15, 17, or 20 mg/kg, i.p.) vehicle on...
Repeated intermittent exposure to psychostimulants, such as amphetamine, leads a progressive enhancement of the drug's ability increase both behavioral and brain neurochemical responses. The expression these enhancements, known sensitization, can be regulated by Pavlovian conditioned stimuli. Cues that are associated with drug experience facilitate sensitization so it only occurs in presence stimuli (context-specific sensitization). In contrast, cues explicitly related absence drugs...
Laparoscopic cholecystectomy remains one of the most common surgical operations. Common bile duct stones (CBDS) are estimated to be present in 10%-20% individuals with symptomatic gallstones. Preoperative magnetic resonance cholangiopancreatography (MRCP) and intraoperative cholangiography (IOC) remain methods evaluation, subsequent endoscopic retrograde (ERCP) for stone extraction if positive CBDS. We examined our experience preoperative MRCP versus IOC management jaundiced patient...