A5016816015- Gene Regulatory Network Analysis
- Photoreceptor and optogenetics research
- Nonlinear Dynamics and Pattern Formation
- Biofuel production and bioconversion
- Microtubule and mitosis dynamics
- Evolutionary Algorithms and Applications
- Sleep and Wakefulness Research
- Plant Molecular Biology Research
- Microbial Metabolic Engineering and Bioproduction
- Circadian rhythm and melatonin
- Light effects on plants
- Modular Robots and Swarm Intelligence
- Single-cell and spatial transcriptomics
- Evolution and Genetic Dynamics
Centre for Plant Biotechnology and Genomics
2024
Universidad Politécnica de Madrid
2011-2024
Centro Nacional de Biotecnología
2024
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
2024
Silesian University in Opava
2014-2015
Negative and positive transcriptional feedback loops are present in natural synthetic genetic oscillators. A single gene with negative needs a time delay sufficiently strong nonlinearity the transmission of signal order to produce biochemical rhythms. only does not oscillations. Here, we demonstrate that this single-gene network conjunction simple interaction can also easily We examine model comprised two well-differentiated parts. The first is created by protein binds promoter its own...
Abstract Genetic circuits confer computing abilities to living cells, performing novel transformations of input stimuli into output responses. These genetic are routinely engineered for insertion bacterial plasmids and chromosomes, using a design paradigm whose only spatial consideration is linear ordering the individual components. However, chromosomal DNA has complex three dimensional conformation which alters mechanics gene expression, leading dynamics that specific location. Here we...
Abstract The programming of computations in living cells can be done by manipulating information flows within genetic networks. Typically, a single bit is encoded gene’s steady state expression. Expression discretized into high and low levels that correspond to 0 1 logic values, analogous the voltages electronic circuits. However, processes molecular signaling computation systems challenge this computational paradigm with their dynamic, stochastic continuous operation. Although there good...
Synthetic microbial consortia can leverage their expanded enzymatic reach to tackle biotechnological challenges too complex for single strains, such as lignocellulose valorisation. The benefit of metabolic cooperation comes with a catch - installing stable interactions between consortium members. We constructed syntrophic Pseudomonas putida strains lignocellulosic disaccharide processing. Two were engineered hydrolyse and metabolise sugars: one grows on xylose hydrolyses cellobiose produce...
Non-coding RNA molecules are able to regulate gene expression and play an essential role in cells. On the other hand, bistability is important behaviour of genetic networks. Here, we propose study ODE model order show how non-coding can produce a simple way. The comprises single with positive feedback that repressed by molecules. We values all reaction rates involved control transitions between high low states. This new be interesting clarify As well, these results synthetic biology for...
The master circadian pacemaker in mammals is localized a small portion of the brain called suprachiasmatic nucleus (SCN). It unclear how SCN produces rhythms. A common interpretation that oscillations through coupling genetic oscillators neurons. effected by network neuropeptides and second messengers. This crucial for correct function SCN. However, models study possible oscillatory behavior itself have received little attention. Here we propose analyze model to examine this potential. We...