A5027628642- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Quantum Dots Synthesis And Properties
- Plasmonic and Surface Plasmon Research
- Spectroscopy and Quantum Chemical Studies
- Electrochemical Analysis and Applications
- Nanoparticle-Based Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bacteriophages and microbial interactions
- SARS-CoV-2 detection and testing
- Nanoplatforms for cancer theranostics
- Radiation Therapy and Dosimetry
University of Victoria
2020-2023
Universidade Estadual de Campinas (UNICAMP)
2017
The concept of plasmonic "hotspots" is central to the broad field nanophotonics. In surface-enhanced Raman scattering (SERS), hotspots can increase efficiency by orders magnitude. Hotspot dimensions may range from a few nanometers down atomic scale and are able generate SERS signals single molecules. However, these single-molecule often show significant fluctuations, intense, localized, yet static has come into question. Recent experiments have shown intensity fluctuations (SIFs) occur over...
Surface-enhanced Raman scattering (SERS)-based immunoassays have several advantages, such as high sensitivity and multiplex capabilities; they are emerging a potential avenue for early disease diagnosis screening. Here, we focused on SERS-based heterogeneous immunoassays, in which the number of extrinsic labels (ERLs) at sensor surface is related to concentration intended target. The ERLs made gold nanoparticles constructed be selective target boost signal reporter. However, biomarker...
The rational synthesis of alternative materials is highly demanding due to the outbreak infectious diseases and resistance antibiotics. Herein, we report a tailored nanoantibiotic protocol where antibiotic binding was optimized on silver-silica core-shell nanoparticles surface maximize biological responses. obtained silver coated with mesoporous silica functionalized ampicillin presented remarkable antimicrobial effects against susceptible antibiotic-resistant Escherichia coli. In addition,...
Fluctuations in Surface Enhanced Raman Spectroscopy (SERS) signals are a hallmark of few-to-single molecule events. Recent experiments have shown these SERS intensity fluctuations (SIFs) to occur over an extremely wide range time scales, from seconds microseconds. While many mechanisms been proposed, such as molecular diffusion or transient plasmonic hotspot generation, the underlying source is likely be complex interplay different effects. For example, done with fully coated, but dry,...
One of the major issues in current radiotherapy (RT) is associated normal tissue toxicity. Enhancement RT effect with novel radiosensitizers can address this need. In study, gold nanoparticles (GNPs) and bleomycin (BLM) were used as a unique combination radiosensitizers. GNPs offer two-fold promise delivery vehicle for BLM radiosensitizing agent. functionalized complexed using gold-thiol bond (denoted GNP-BLM). Our results show that there was 40% 10% decrease cell growth GNP-BLM vs. free MIA...
The observation of single molecule events using surface-enhanced Raman scattering (SERS) is a well-established phenomenon. These are characterized by strong fluctuations in SERS intensities. High-speed intensity (in the microsecond time scale) have been reported for experiments involving metallic particles. In this work, high-speed behavior six different types nanostructured metal systems (Ag nanoshells, Ag nanostars, aggregated spheres, Au particle-on-mirror, and deposited on microspheres)...
Surface-enhanced Raman scattering (SERS) is a sensitive, widely used spectroscopic technique. However, SERS perceived as poorly reproducible and insufficiently robust for standard applications in analytical chemistry. Here, we demonstrated that reliable immunoassay quantification at low concentrations (pM range) can be achieved by careful experimental design appropriate data analysis statistics. A SERS-based IgG human serum (3.1–50.0 ng mL–1 or 20.6–333 pM) was developed proof of concept....
A biosensor based on AgNPs immobilized in plastic is used to detect infectious agents from saliva samples.