A5021747277- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Epigenetics and DNA Methylation
- Asymmetric Synthesis and Catalysis
- Glycosylation and Glycoproteins Research
- Electrochemical Analysis and Applications
- Cancer-related gene regulation
- Chemical synthesis and alkaloids
- PI3K/AKT/mTOR signaling in cancer
- American Environmental and Regional History
- Marine Toxins and Detection Methods
- Catalysis for Biomass Conversion
- Chemical Synthesis and Analysis
- Chemical Reaction Mechanisms
- Adenosine and Purinergic Signaling
- Coordination Chemistry and Organometallics
- Advanced Synthetic Organic Chemistry
- Conducting polymers and applications
- Biofuel production and bioconversion
- Signaling Pathways in Disease
- Proteoglycans and glycosaminoglycans research
- Glycogen Storage Diseases and Myoclonus
- Underground infrastructure and sustainability
- Crystallization and Solubility Studies
- Click Chemistry and Applications
University of Liverpool
2013-2022
University of Oxford
2007-2009
University of Manchester
2006-2007
Mutations in the gene encoding Cu/Zn superoxide dismutase-1 cause amyotrophic lateral sclerosis. Superoxide mutations decrease protein stability and promote aggregation. The mutant monomer is thought to be an intermediate pathway from dimer aggregate. Here we find that monomeric copper-apo, zinc-holo structurally perturbed apo-protein aggregates without reattainment of monomer–dimer equilibrium. Intervention stabilize inhibit aggregation regarded as a potential therapeutic strategy. We...
Opening of the mitochondrial permeability transition pore (MPTP) causes dysfunction and necrosis in acute pancreatitis (AP), a condition without specific drug treatment. Cyclophilin D (CypD) is matrix peptidyl-prolyl isomerase that regulates MPTP target for AP. We have synthesized urea-based small molecule inhibitors cyclophilins tested them against CypD using binding activity assays. Thermodynamic profiles CypD/inhibitor interactions were determined by isothermal titration calorimetry....
Closing the deal: A ring-closing metathesis (RCM)/aromatization protocol, followed by a regioselective Negishi cross-coupling reaction and macrolactonization, with subsequent RCM mediate synthesis of (−)-(Z)-deoxypukalide in 12 linear steps 15 % overall yield (see retrosynthesis; TBS=tert-butyldimethylsilyl, TIPS=triisopropylsilyl). Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z802703_s.pdf or from author. Please note: The...
Carboxyl methyltransferase (CMT) enzymes catalyse the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that FtpM from Aspergillus fumigatus can methylate a broad range aromatic mono- dicarboxylic good to excellent conversions. The shows high regioselectivity on its natural substrate fumaryl-l-tyrosine, trans, trans-muconic acid number tested. Dicarboxylic are generally better substrates than monocarboxylic...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterised by the selective dysfunction and death of upper lower motor neurons. Median survival rates are between 3 5 years after diagnosis. Mutations in gene encoding Cu/Zn superoxide dismutase (SOD1) have been linked to subset familial forms ALS (fALS). Herein, we describe fragment- based drug discovery (FBDD) approach for investigation small molecule binding sites SOD1. X-ray crystallography has used as...
Lithium metal reductions are widely employed in organic synthesis, where it is common to employ a "mediator" speed up the electron transfer kinetics. We present experimental data for electrode kinetics of reduction most mediator, 4,4'-di-tert-butyl-1,1'-biphenyl (DBB) tetrahydrofuran (THF) over range temperatures. Using corresponding oxidation lithium we quantitative estimates kinetic advantage use DBB as mediator reductions, over, particular, direct using metal.
Abstract The reduction of methyl benzoate was studied in tetrahydrofuran (THF), 0.1 M TBAP, both at platinum and glassy carbon macroelectrodes microelectrodes. While cyclic voltammograms obtained show extensive distortion due to ohmic drop, this is negligible for system benzoate/methyl radical anion found be chemically reversible. fitting chronoamperometric measurements using the Shoup Szabo's expression microdisc electrodes allowed us estimate diffusion coefficient benzoate. Cyclic...
Ring um Ring: Eine Ringschlussmetathese (RCM) mit anschließender Aromatisierung, eine regioselektive Negishi-Kreuzkupplung, Makrolactonisierung und weitere RCM (siehe die Retrosynthese) führen zu (−)-(Z)-Desoxypukalid, das in 12 linearen Stufen 15 % Gesamtausbeute erhalten wird. TBS=tert-Butyldimethylsilyl, TIPS=Triisopropylsilyl.
Sulfotransferases (STs) catalyse the transfer of a sulfonyl group ('sulfation') from enzyme co-factor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to variety biomolecules. Tyrosine sulfation proteins and carbohydrate play crucial role in many protein-protein interactions cell signalling pathways extracellular matrix. This is catalysed by several membrane-bound STs, including tyrosylprotein sulfotransferase 1 (TPST1) heparan sulfate 2-O-sulfotransferase (HS2ST1). Recently, involvement these...
Abstract This review describes the protocol, procedures and methods for electrochemical studies in THF at low temperature that have been developed course of last 5 years our laboratory. Electrochemical benefit from a large accessible potential window. In practice, it is however necessary to avoid presence humidity cell. A specific reference electrode had be designed those measurements. Microelectrodes, voltammetric response which negligibly affected by resistivity medium, were preferred...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access Abstract, please click on HTML or PDF.
Abstract Carboxyl methyltransferase (CMT) enzymes catalyse the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that FtpM from Aspergillus fumigatus can methylate a broad range aromatic mono‐ dicarboxylic good to excellent conversions. The shows high regioselectivity on its natural substrate fumaryl‐ l ‐tyrosine, trans , ‐muconic acid number tested. Dicarboxylic are generally better substrates than...