Tuğba Ocak

ORCID: 0000-0002-4560-1569
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Research Areas
  • Spondyloarthritis Studies and Treatments
  • Autoimmune and Inflammatory Disorders Research
  • Renal Diseases and Glomerulopathies
  • Inflammasome and immune disorders
  • Psoriasis: Treatment and Pathogenesis
  • Viral Infections and Vectors
  • Liver Disease Diagnosis and Treatment
  • Cerebral Palsy and Movement Disorders
  • COVID-19 Clinical Research Studies
  • Chronic Kidney Disease and Diabetes
  • Renal and Vascular Pathologies
  • Appendicitis Diagnosis and Management
  • Problem Solving Skills Development
  • Musculoskeletal pain and rehabilitation
  • Family and Disability Support Research
  • Education Practices and Challenges
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Cancer and Skin Lesions
  • Metastasis and carcinoma case studies
  • Liver Diseases and Immunity
  • IL-33, ST2, and ILC Pathways
  • Liver Disease and Transplantation
  • Breast Lesions and Carcinomas
  • Dialysis and Renal Disease Management
  • Hepatitis Viruses Studies and Epidemiology

Bursa Technical University
2025

Bursa Uludağ Üni̇versi̇tesi̇
2016-2024

Haseki Eğitim ve Araştırma Hastanesi
2016

Familial Mediterranean Fever (FMF) is characterized by recurrent febrile attacks and serositis. While colchicine the primary treatment for FMF, some patients present resistance or intolerance with respect to this drug. Anakinra—an IL-1 receptor antagonist—has demonstrated efficacy in colchicine-resistant -intolerant FMF patients. Background Objectives: This study aimed evaluate clinical characteristics, duration, response therapy, dose interval modifications, long-term outcomes treated...

10.3390/medicina61050792 article EN cc-by Medicina 2025-04-25

Familial Mediterranean fever (FMF) is characterized by recurrent episodes of and serositis. Blood-based biomarkers determined in FMF patients during attack-free periods could be used to predict the risk amyloidosis severity disease. The recently defined pan-immune-inflammation value (PIV) comprises four distinct subsets blood cells serves as an easily accessible cost-effective marker. objective this study was assess role PIV predicting moderate-to-severe Clinical characteristics laboratory...

10.3390/diagnostics14060634 article EN cc-by Diagnostics 2024-03-16

Ailevi Akdeniz Ateşi (AAA) 10 ekzondan oluşan Mediterranean Fever (MEFV) geninde meydana gelen mutasyonlar sonucu tekrarlayan ateş ve serözit ataklarıyla seyreden otoinflamatuar bir hastalıktır. Ekzon lokasyonunda mutasyon pozitifliği tipik klinik fenotiple amiloidoz, böbrek yetmezliği gibi hastalık komplikasyonlarıyla ilişkilidir. Çalışmamızda 10. ekzonda varlığının özellikler komplikasyonlar ile ilişkisini saptamayı amaçladık. Hastanemiz romatoloji kliniğinde Ocak 2015-Ağustos 2023...

10.32708/uutfd.1410535 article TR Uludağ Üniversitesi Tıp Fakültesi Dergisi 2024-04-03

Patients with axial spondyloarthritis (axSpA) who receive immunosuppressive therapy are at risk of infection due to impaired immune function and medication. Vaccination plays a crucial role in preventing infections this population. However, vaccination rates factors influencing uptake axSpA patients still need be adequately studied. This study was designed determine the vaccines covered by health insurance particular group Turkey attitudes towards infections. survey included 199 visited our...

10.3390/vaccines12070756 article EN cc-by Vaccines 2024-07-09

: Secukinumab is a monoclonal antibody against interleukin 17 approved for patients with axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), and psoriasis. Treating axSpA PsA history of malignancy challenge. While initial results on the applicability secukinumab in this patient group are positive, number studies topic remains limited. This study aimed to investigate drug's survival time efficacy safety treatment specific group.

10.3390/jcm13206216 article EN Journal of Clinical Medicine 2024-10-18

Erişkin Still hastalığı (ESH) multigenik otoinflamatuar bir hastalıktır. İnterlökin (IL)-1 inhibitörleri tedaviye dirençli ESH’de kullanılabilir. Çalışmamızda IL-1 inhibitörlerinin etkinlik ve yan etkileri ile ilgili gerçek yaşam deneyimimizi sunmayı amaçladık. Hastanemiz romatoloji kliniğinde Ocak 2016-Mart 2024 tarihleri arasında ESH tanısı takip edilen 24 hastanın dosyası retrospektif olarak incelendi. Anakinra alan 22 hasta kanakinumab 5 mevcuttu. Kanakinumab hastalardan 3 tanesi daha...

10.32708/uutfd.1559614 article TR Uludağ Üniversitesi Tıp Fakültesi Dergisi 2024-11-03

Information and education are recommended for patients with inflammatory arthritis including spondyloarthritis (SpA). However, there is no Turkish instrument available to measure the knowledge level of SpA. The study aimed translate Spondyloarthritis Knowledge Questionnaire (SPAKE) into investigate its validity reliability.

10.5152/eurjrheum.2024.24005 article EN PubMed 2024-09-05

Spontaneous bacterial peritonitis (SBP) is an important reason for mortality in cirrhosis. This study aimed to identify the factors associated with SBP.A total of 69 patients cirrhosis and 74 SBP attacks that occurred this group were assessed. Demographic data, symptoms at admission, comorbidities, laboratory parameters, treatment protocols, causes cirrhosis, scoring characteristics, complications, analyzed.Model end-stage liver disease (MELD; p = 0.001), sodium-MELD (p Child-Pugh-Turcotte...

10.5005/jp-journals-10018-1387 article EN Euroasian Journal of Hepato-Gastroenterology 2023-08-03

ÖzGiriş: Fokal segmental glomerüloskleroz (FSGS) dünya genelinde en sık görülen glomerülonefritler (GN) arasında yer almaktadır.Hastalık tedaviye rağmen son dönem böbrek yetmezliğine ilerleyebilmektedir.Çalışmamızda FSGS ile primer ve sekonder GN'leri klinik histopatolojik verilerine göre retrospektif olarak değerlendirdik.Yöntemler: Çalışmamızda 1 Ocak 2009-31 Aralık 2014 tarihleri renal biyopsi tanı koyulan diğer GN hastaları klinik, laboratuvar özellikleri, yanıtları mortalite ilgili risk...

10.4274/haseki.2941 article TR cc-by-nc-nd Medical Bulletin of Haseki 2016-09-29

Introduction: Chronic inflammatory diseases (CIDs) are lifelong complex disorders that affect quality of life, and this study aimed to summarize 5 years experience with a multidisciplinary approach for these as result medical council meetings.
 Methods: Hospital-based, records review was conducted. A total 45 monthly meetings were held between 2014-2019 the participation rheumatology, dermatology gastroenterology departments same university. Patients conditions seen in each department's...

10.46310/tjim.958247 article EN cc-by-nc-nd Turkish Journal of Internal Medicine 2022-01-28
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