Tuyet M. Tan
A5037907931- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Erythrocyte Function and Pathophysiology
- Parvovirus B19 Infection Studies
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Evolution and Genetic Dynamics
University of California, San Diego
2024
Moores Cancer Center
2022
Abstract Current methods for analyzing chromatin architecture are not readily scalable to heterogeneous tissues. Here we introduce Droplet Hi-C, which uses a commercial microfluidic device high-throughput, single-cell conformation profiling in droplets. Using mapped the of mouse cortex and analyzed gene regulatory programs major cortical cell types. In addition, used this technique detect copy number variations, structural variations extrachromosomal DNA human glioblastoma, colorectal blood...
Abstract SF3B1 mutations, which occur in 20% of patients with myelodysplastic syndromes (MDS), are the hallmarks a specific MDS subtype, ringed sideroblasts (MDS-RS), is characterized by accumulation erythroid precursors bone marrow and primarily affects elderly population. Here, using single-cell technologies functional validation studies primary SF3B1-mutant MDS-RS samples, we show that mutations lead to activation EIF2AK1 pathway response heme deficiency targeting this rescues aberrant...
Supplementary Data from Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in <i>SF3B1</i>-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts
Supplementary Data from Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in <i>SF3B1</i>-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts
<div>Abstract<p><i>SF3B1</i> mutations, which occur in 20% of patients with myelodysplastic syndromes (MDS), are the hallmarks a specific MDS subtype, ringed sideroblasts (MDS-RS), is characterized by accumulation erythroid precursors bone marrow and primarily affects elderly population. Here, using single-cell technologies functional validation studies primary <i>SF3B1</i>-mutant MDS-RS samples, we show that <i>SF3B1</i> mutations lead to...
Supplementary Data from Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in <i>SF3B1</i>-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts
Supplementary Data from Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in <i>SF3B1</i>-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts
<div>Abstract<p><i>SF3B1</i> mutations, which occur in 20% of patients with myelodysplastic syndromes (MDS), are the hallmarks a specific MDS subtype, ringed sideroblasts (MDS-RS), is characterized by accumulation erythroid precursors bone marrow and primarily affects elderly population. Here, using single-cell technologies functional validation studies primary <i>SF3B1</i>-mutant MDS-RS samples, we show that <i>SF3B1</i> mutations lead to...