A5079072045- Diabetes Management and Research
- Gestational Diabetes Research and Management
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Bariatric Surgery and Outcomes
- Advanced Glycation End Products research
- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Diabetes Management and Education
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Health and Lifestyle Studies
- Heart Rate Variability and Autonomic Control
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- Breastfeeding Practices and Influences
- Infant Nutrition and Health
- Pharmacology and Obesity Treatment
Barnes-Jewish College
2019-2025
Washington University in St. Louis
2019-2025
University of Colorado Anschutz Medical Campus
2016-2019
University of Illinois Chicago
2014-2018
University of Colorado Denver
2016-2018
The Medical Center of Aurora
2018
University of Illinois Urbana-Champaign
2016
Neurobehavioral Systems
2016
There is considerable heterogeneity in the cardiometabolic abnormalities associated with obesity. We evaluated multi-organ system metabolic function 20 adults metabolically healthy obesity (MHO; normal fasting glucose and triglycerides, oral tolerance, intrahepatic triglyceride content, whole-body insulin sensitivity), unhealthy (MUO; prediabetes, hepatic steatosis, resistance), 15 who were lean. Compared MUO, people MHO had (1) altered skeletal muscle biology (decreased ceramide content...
IN BRIEF Far from a simple absence of wakefulness, sleep is an active, regulated, and metabolically distinct state, essential for health well-being. In this article, the authors review fundamental anatomy physiology its regulation, with eye toward interactions between metabolism.
Maternal obesity (OB) accounts for the majority of large-for-gestational-age infants, and newborn percent fat (NB%fat) correlates strongest with childhood OB. In addition to maternal glucose, fasting triglycerides (TGs) may contribute, but postprandial (PPTGs) are unstudied. It was hypothesized that TGs PPTGs higher in women OB compared normal weight (NW) throughout pregnancy, correlate more strongly NB%fat than relate dietary chylomicron TGs.Fasting PPTGs, free fatty acids, insulin were...
IN BRIEF In people with type 1 diabetes, sleep may be disrupted as a result of both behavioral and physiological aspects diabetes its management. This disruption negatively affect disease progression development complications. review highlights key research findings regarding in diabetes.
The soluble receptor for advanced glycation end products (sRAGE) may be protective against inflammation associated with obesity and type 2 diabetes (T2DM). aim of this study was to determine the distribution sRAGE isoforms whether are risk T2DM development in subjects spanning glucose tolerance continuum. In retrospective analysis, circulating total endogenous secretory RAGE (esRAGE) were quantified via ELISA, cleaved (cRAGE) calculated 274 individuals stratified by status (GTS) obesity....
Introduction Women of reproductive age (18–44 years) are at an increased risk developing obesity due to pregnancy, life-transitions, and marginalization. Obesity in women negatively affects women’s health pregnancy outcomes can increase their children will develop obesity. Less is known about the interpersonal environmental levels for age. This study uses socioecological model explore across ecological levels. Materials methods A secondary cross-sectional analysis was conducted using...
Abstract Aims To examine sleep quality and its associations with glycaemic control, variability (GV), fear of hypoglycaemia (FOH) in adults type 1 diabetes. Background Poor has negative health consequences is a frequent complaint among Sleep diabetes likely affected by glucose levels as well stressors associated managing chronic condition. Design A retrospective secondary analysis pooled data from two previous cross‐sectional studies was conducted. Methods We examined subjective quality,...
OBJECTIVE Nutrition therapy for gestational diabetes mellitus (GDM) has conventionally focused on carbohydrate restriction. In a randomized controlled trial (RCT), we tested the hypothesis that diet (all meals provided) with liberalized complex (60%) and lower fat (25%) (CHOICE diet) could improve maternal insulin resistance 24-h glycemia, resulting in reduced newborn adiposity (NB%fat; powered outcome) versus conventional lower-carbohydrate (40%) higher-fat (45%) (LC/CONV) diet. RESEARCH...
Accurate objective measurement of sleep, an important health behavior, is needed. Individuals with type 1 diabetes mellitus (T1DM) have altered sleep architecture and reduced quality in comparison healthy controls. The aim this investigation was to compare a commonly used actigraphy device, Actiwatch2, polysomnography (PSG)-based measures young adults T1DM, determine which Actiwatch2 threshold setting provides the best correspondence.Subjects age 18-30 years T1DM wore while simultaneously...
To determine the effects of dronabinol on quantitative electroencephalogram (EEG) markers sleep process, including power distribution and ultradian cycling in 15 patients with obstructive apnea (OSA).EEG (C4-A1) relative (% total) delta, theta, alpha, sigma bands was quantified by fast Fourier transformation (FFT) over 28-second intervals. An activation ratio (AR = [alpha + sigma] / [delta theta]) also computed for each interval. assess rhythms, best-fitting cosine wave determined AR...
Objective: We measured the effects of a single bout exercise on diurnal and nocturnal oxidative stress glycaemic variability in obese subjects with type 2 diabetes mellitus or impaired glucose tolerance versus healthy controls. Methods: Subjects (in random order) performed either 30-min moderate-intensity remained sedentary for 30 min at two separate visits. To quantify variability, standard deviation (measured by continuous monitoring system) overlapping net action 1-h intervals (CONGA-1)...
Abstract Objective Often unrecognized, obstructive sleep apnea (OSA) worsens over pregnancy and is associated with poorer perinatal outcomes. The association between OSA in late metabolic biomarkers remains poorly understood. We tested the hypothesis that pregnant women obesity positively correlated 24-hour patterns of glycemia IR despite controlling for diet. Design Pregnant (32 to 34 weeks’ gestation; body mass index, 30 40 kg/m2) wore a continuous glucose monitor 3 days. was measured...
Glucose variations are common throughout sleep and wakefulness in people with type 1 diabetes mellitus (T1DM). The objective of this investigation was to characterize the time-varying coupling between glucose unstructured physical activity over a 60-hr period young adults T1DM. hypothesis that would differ during versus exhibit circadian variations.Young T1DM treated an insulin pump participated study. were monitored continuous monitoring system, assessed using activity-monitoring band worn...
Background: Elevated cardiovascular disease risk in people with type 1 diabetes (T1DM) is incompletely understood. Glycemic control, glycemic variability, and sleep quality duration may relate to this population via endothelial dysfunction. Objective: The aim of study was examine relationships among duration, function adults T1DM. Methods: Endothelial measured using flow-mediated dilation. control variability were A1C a continuous glucose monitor, respectively; the Pittsburgh Sleep Quality...
Advanced glycation end products (AGEs) promote the development of diabetic complications through activation their receptor (RAGE). Isoforms soluble RAGE (sRAGE) sequester AGEs and protect against RAGE-mediated complications. We investigated effect an overnight fast on circulating metabolic substrates, hormones, AGEs, sRAGE isoforms in 26 individuals with type 1 diabetes (T1DM). Blood was collected from young (18⁻30 years) T1DM patients insulin pumps before after fast. Circulating were...
Abstract People with obesity who do not have the metabolic syndrome or components of been characterized as having metabolically healthy (MHO). However, existence MHO has questioned because people are at greater risk developing diabetes and fatal cardiovascular disease than lean healthy. Here we report findings from a 25-year-old woman rigorously defined (normal oral glucose tolerance, insulin sensitivity [assessed using hyperinsulinemic-euglycemic clamp procedure], plasma triglyceride,...