A5022737092- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Analytical Chemistry and Sensors
- Luminescence and Fluorescent Materials
- Graphene and Nanomaterials Applications
- thermodynamics and calorimetric analyses
- Graphene research and applications
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Molecular Sensors and Ion Detection
- Microbial Metabolic Engineering and Bioproduction
- Field-Flow Fractionation Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- Granular flow and fluidized beds
- Carbon and Quantum Dots Applications
- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
- Click Chemistry and Applications
- Pharmacological Effects and Toxicity Studies
- Advanced Biosensing Techniques and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
Centre National de la Recherche Scientifique
2015-2022
Institut Pasteur
2020-2022
Laboratoire de Biologie et Pharmacologie Appliquée
2022
Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires
2015-2022
Université Paris-Saclay
2019-2020
École Normale Supérieure Paris-Saclay
2015-2019
Wuhan University
2010-2012
China University of Geosciences
2009-2010
Ministry of Education of the People's Republic of China
2010
It was found that the chemiluminescence of acridinium ester (AE) quenched effectively by gold nanoparticles (AuNPs) with Stern–Volmer constants approaching 1010 M−1, which exploited to realize sequence-specific DNA detection based on preferential absorption AE-tagged single-strand probe unmodified AuNPs over hybrids and target DNA.
An amplified multiplexed DNA detection biosensor has been developed, which combines the unique cleavage function of exonuclease III (Exo III) with separating ability magnetic microparticles (MMPs). By using different fluorophores, is demonstrated.
Abstract This study investigated the interaction processes of ciprofloxacin (CIP) with graphene oxide (GO) and reduced GO (rGO) in presence montmorillonite (Mont) simulated gastrointestinal fluids. The order CIP adsorption affinity was rGO+Mont > GO+Mont rGO+Mont+pepsin rGO GO+Mont+pepsin Mont Mont+pepsin rGO+pepsin GO+pepsin gastric fluid. enhanced on due to hydrated Si species coating Meanwhile, π–π between caused great shift two cyclopropyl CH 2 one molecules. And GO, rGO, interacted...
Novel fluorescent labels with high photostability and biocompatibility are required for microbiological imaging detection. Here, we present a green polymer chain (GFPC), designed to be nontoxic water-soluble, multicolor bioimaging real-time bacterial viability determination. The copolymer is synthesized using straightforward one-pot reversible addition–fragmentation chain-transfer (RAFT) polymerization technique. We show that GFPC does not influence growth stable several hours in complex...
Histone methyltransferase DOT1L catalyzes mono-, di- and trimethylation of histone 3 at lysine residue 79 (H3K79) hypermethylation H3K79 has been linked to the development acute leukemias characterized by MLL (mixed-lineage leukemia) rearrangements (MLLr cells). The inhibition methylation inhibits MLLr cells proliferation, an inhibitor specific for DOT1L, pinometostat, was in clinical trials (Phase Ib/II). However, compound showed poor pharmacological properties. Thus, there is a need find...
By a novel screening strategy, we identified Compound 4, published CARM1 inhibitor, inhibits both histone mark H3R2me2a, regulated also by CARM1, and H3K79me2, only DOT1L, pointing out crosstalk between DOT1L.
Background: Post-translational modifications of histones constitute a dynamic process impacting gene expression. A well-studied modification is lysine methylation. Among the histone methyltransferases, DOT1L implicated in various diseases, making it very interesting target for drug discovery. has two substrates, SAM cofactor that gives methyl group and H3K79 substrate. Results: Using molecular docking, authors explored new bisubstrate analogs to enlarge chemical landscape inhibitors. The...