A5044011854- Calcium signaling and nucleotide metabolism
- Phenothiazines and Benzothiazines Synthesis and Activities
- Toxin Mechanisms and Immunotoxins
- Cyclopropane Reaction Mechanisms
- Synthesis and Biological Evaluation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Analysis
- Adenosine and Purinergic Signaling
- Synthesis and pharmacology of benzodiazepine derivatives
Northeastern University
2017
An expeditious route to fused triazolo-pyrido benzoxazepines has been developed using flow and microwave-mediated cyclization chemistry. A range of substituted aryl hydrazides are coupled with a core chloroimine in good excellent yield via Pellizzari type process, producing 1,2,4-triazolo-pyrido [<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mn fontstyle="italic">2</mml:mn></mml:mrow></mml:math>,<mml:math id="M2"><mml:mrow><mml:mn...
Several monoclonal antibodies and inhibitors targeting CD38, an ectoenzyme overexpressed on malignant plasma cells, have previously been discovered. Herein, we expand structure-activity relationships of reported small-molecule thiazoloquinolinones show that several 4-cyclohexylamino analogues potent binding affinity for CD38 using surface plasmon resonance. Moreover, active amine could be acylated functionalized with alkyne fluorescein groups. Fluorescein analogue 21 bound selectively to...