A5007230712- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Immune Response and Inflammation
- Trauma Management and Diagnosis
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Pleural and Pulmonary Diseases
- Advanced Chemical Sensor Technologies
- Medical Imaging and Pathology Studies
- Diet and metabolism studies
- Vitamin C and Antioxidants Research
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Liver physiology and pathology
- Sulfur Compounds in Biology
- Forensic Toxicology and Drug Analysis
- Healthcare Decision-Making and Restraints
- Congenital Heart Disease Studies
- Macrophage Migration Inhibitory Factor
- Protein Kinase Regulation and GTPase Signaling
- NF-κB Signaling Pathways
Sharp Memorial Hospital
2012-2019
University of California, San Diego
2002
University of California San Diego Medical Center
2000
Saint Louis University
1996-1998
Activation of the resident macrophage populations reticuloendothelial system is a key component complex pathophysiology sepsis. Macrophage activation leads to production and secretion inflammatory mediators such as cytokines, vasoactive substances, free radicals, chemokines, which have been associated with high morbidity mortality in septic patient. The goal present study was determine whether antioxidants could suppress Kupffer cell at points beyond initiation activation. cells were studied...
Cytokines, growth factors, and alterations in the extracellular matrix composition may play a role maintaining hepatic stellate cells (HSC) activated state that is responsible for fibrogenesis. However, signal transduction pathways are stimulated by these factors HSC remain to be fully elucidated. Recent evidence indicates mitogen-activated protein kinase (MAPK) family, including c-Jun NH 2 -terminal (JNK) signal-regulated (ERK), plays an important cellular response stress. The aims of this...
Lipopolysaccharide (LPS) activation of macrophages occurs after LPS complexed with serum LPS-binding protein (LBP) binds CD14. Activation the nuclear transcription factor NF-kappa B is directly related to this event. Since role CD14 in signaling has not been evaluated Kupffer cells, resident hepatic macrophage, purpose study was characterize LPS-mediated under CD14-dependent (1% serum, as a source LBP) and CD14-independent (serum-free) conditions. Classic seen peritoneal where potentiated...
Proinflammatory cytokines released by hepatic macrophages (Kupffer cells) have a central role in the pathogenesis of liver injury and cardiovascular abnormalities sepsis. Because cytokine release is controlled primarily at level gene expression, intracellular signalling mechanisms that control transcription genes are critical links to organ injury. Oxidant stress up-regulates antioxidants down-regulate pleiotropic factor NF-κB, DNA-binding protein induces expression vascular adhesion...
Extracorporeal membrane oxygenation (ECMO) has several applications as a resuscitative intervention, including extracorporeal cardiopulmonary resuscitation (ECPR). ECPR is rarely initiated in the emergency department (ED) by physicians outside regional academic institutions.To evaluate whether improves clinical outcomes after cardiac arrest when (EPs) nonacademic hospital.We performed retrospective analysis of prospectively identified consecutive EP-initiated ECMO subjects from single...
Introduction: Patients with implanted Left ventricular assist devices (LVAD) are being assessed by an increasing number of health care providers. Despite a lack evidence, many emergency medical systems and hospitals have discouraged providers from performing chest compressions in these patients when they present cardiac arrest. This deviation conventional resuscitation algorithms is secondary to concern that could dislodge the LVAD. Objective: To determine rate cannula dislodgment for...