A5017964625- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Magnetism in coordination complexes
- Radiopharmaceutical Chemistry and Applications
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Quantum Chromodynamics and Particle Interactions
- X-ray Diffraction in Crystallography
- Particle physics theoretical and experimental studies
- Protein Interaction Studies and Fluorescence Analysis
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Atomic and Molecular Physics
- Cancer Treatment and Pharmacology
- Synthesis and Characterization of Heterocyclic Compounds
- Chronic Myeloid Leukemia Treatments
- Asymmetric Hydrogenation and Catalysis
- Black Holes and Theoretical Physics
University of Vienna
2008-2025
Abstract Clinical efficacy of oxaliplatin is frequently limited by severe adverse effects and therapy resistance. Acquired insensitivity to is, at least in part, associated with elevated levels glutathione (GSH). In this study we report on an oxaliplatin-based platinum(IV) prodrug, which releases L -buthionine- S , R -sulfoximine (BSO), inhibitor glutamate-cysteine ligase, the rate-limiting enzyme GSH biosynthesis. Two complexes bearing either acetate ( BSO-OxOAc ) or albumin-binding...
Abstract Maleimides are essential compounds for drug conjugation reactions via thiols to antibodies, peptides and other targeting units. However, one main drawback is the occurrence of thiol exchange with, example, glutathione resulting in loss ability. A new strategy overcome such retro‐Michael processes maleimide–thiol conjugates by stabilization thiosuccinimide a transcyclization reaction presented. This enables straightforward synthesis stable adducts drug‐conjugation applications.
Due to their high kinetic inertness and consequently reduced side reactions with biomolecules, Pt
Chemotherapy with platinum complexes is essential for clinical anticancer therapy. However, due to side effects and drug resistance, further improvement urgently needed. Herein, we report on triple-action platinum(IV) prodrugs, which, in addition tumor targeting via maleimide-mediated albumin binding, release the immunomodulatory ligand 1-methyl-d-tryptophan (1-MDT). Unexpectedly, structure–activity relationship analysis showed that mode of 1-MDT conjugation distinctly impacts reducibility...
We investigated the first oxaliplatin( iv ) complexes releasing acetylsalicylic acid (aspirin) upon reduction. The albumin-targeted derivative showed distinctly improved antitumor activity compared to asplatin, a recently reported cisplatin( analog.
Platinum(II) complexes prevail as first-line treatment for many cancers but are associated with serious side effects and resistance development. Picoplatin emerged a promising alternative to circumvent GSH-induced tumor by introducing bulky 2-picoline ligand. Although clinical studies were encouraging, picoplatin did not receive approval. Interestingly, the anticancer potential of prodrugs based on is widely underexplored, even less so respective tumor-targeting approaches. We synthesized...
Abstract Platinum(IV) prodrugs are highly interesting alternatives to platinum(II) anticancer therapeutics due their increased tumor selectivity and reduced side effects. In contrast the established theory, we recently observed that equatorial ligand(s) of e.g. oxaliplatin(IV) complexes can be hydrolyzed with formation [(DACH)Pt(OH eq ) 2 (OAc ax ]. work presented here, investigated reactivity synthetic usability this complex exploited as a precursor for development novel platinum(IV)...
While platinum-based chemotherapeutic agents have established themselves as indispensable components of anticancer therapy, they are accompanied by a variety side effects and the rapid occurrence drug resistance. A promising strategy to address these challenges is use platinum(iv) prodrugs, which remain inert until reach tumor tissue, thereby mitigating detrimental on healthy cells. Typically, platinum drugs part combination therapy settings. Consequently, very elegant development prodrugs...
Abstract Pt IV ‐Komplexe gelten aufgrund ihrer hohen kinetischen Inertheit und der folglich reduzierten Nebenreaktionen mit Biomolekülen als die Zukunft Platintherapeutika. In dieser Arbeit wurde unter physiologisch relevanten Bedingungen Stabilität einer Reihe von ‐Biscarboxylatokomplexen in wässriger Lösung untersucht. Entgegen des derzeitigen chemischen Kenntnisstandes zeigten (sogar Zellkulturmedium Serum) vor allem Oxaliplatin‐ Satraplatinkomplexe eine schnelle äquatoriale Hydrolyse....
Platin(IV)‐Prodrugs sind aufgrund ihrer erhöhten Tumorselektivität und geringeren Nebenwirkungen äußerst interessante Alternativen zu Platin(II)‐Antitumortherapeutika. Im Gegensatz zur gängigen Theorie haben wir kürzlich beobachtet, dass äquatoriale Liganden von z. B. Oxaliplatin(IV)‐Komplexen unter Bildung [(DACH)Pt(OH
We discuss the predictions of standard model for scalar form factors Kl3 decays. Our analysis is based on results chiral perturbation theory, large Nc estimates low-energy couplings and dispersive methods. It includes a discussion isospin violating effects strong electromagnetic origin.