A5006063832- Bacterial biofilms and quorum sensing
- Bacterial Genetics and Biotechnology
- bioluminescence and chemiluminescence research
- Antibiotic Resistance in Bacteria
- Problem and Project Based Learning
- Genetics, Bioinformatics, and Biomedical Research
- Molecular Communication and Nanonetworks
- Bacteriophages and microbial interactions
- Gastrointestinal disorders and treatments
- Plant and Biological Electrophysiology Studies
- Planarian Biology and Electrostimulation
- Bacterial Infections and Vaccines
- Intestinal Malrotation and Obstruction Disorders
- Yersinia bacterium, plague, ectoparasites research
University of Georgia
2018-2025
Georgia State University
2025
ABSTRACT We present a laboratory module that uses isolation of antibiotic-resistant bacteria from locally collected stream water samples to introduce undergraduate students basic microbiological culture-based and molecular techniques. This also educates them on the global public health threat organisms. Through eight sessions, are involved in quality testing sources their neighborhoods, followed by extended-spectrum beta-lactamase-producing Enterobacteriaceae . By end module, should be able...
Why resistance to specific antibiotics emerges and spreads rapidly in some bacteria confronting these drugs but not others remains a mystery. Resistance erythromycin the respiratory pathogens Staphylococcus aureus Streptococcus pneumoniae emerged increased problematically. However, is uncommon amongst classic Bordetella species despite infections being treated with this macrolide for decades.We examined whether apparent progenitor of spp., bronchiseptica, able generate de novo and, if so,...
Spatially dispersed colonies of bacteria can communicate through the release and detection signal molecules. In their experiment, authors monitor biofluorescence induced in cells when concentration a molecular colony reaches critical threshold. Simulations model with growth diffusion reproduce experimental data quite well.
ABSTRACT Bioluminescence in Vibrio fischeri is regulated by a quorum-dependent signaling system composed of LuxI and LuxR. generates N- 3-oxohexanoyl homoserine lactone (3OC6-HSL), which triggers LuxR to activate transcription the luxICDABEG operon responsible for bioluminescence. Surprisingly, ∆ luxI mutant produced more bioluminescence than wild type culture. In contrast, 4 bp duplication within , resulting frameshift mutation null allele, decreased luminescence tenfold. A second encoded...
Many pheromone sensing bacteria produce and detect more than one chemically distinct signal, or autoinducer. The pathways that these signals are typically noisy interlocked through crosstalk feedback. As a result, the response of individual cells is described by statistical distributions change under different combinations signal inputs. Here we examine how reshapes this response. We measure two homoserine lactone (HSL) input alter cell responses in AinS/R- LuxI/R-controlled branches Vibrio...
Many bacteria communicate using diffusible pheromone signals known as autoinducers. When the autoinducer concentration reaches a threshold, which requires minimum population density or 'quorum', activate specific gene regulatory pathways. Simple diffusion of can quorum-dependent pathways in cells that are located at substantial distances from secreting source. However, modeling has predicted diffusion, coupled with positive feedback regulation synthesis, could also allow quorum-regulated...