A5065492325- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Genetics and Neurodevelopmental Disorders
- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Congenital heart defects research
- Neuroscience and Neural Engineering
- Autism Spectrum Disorder Research
- Advanced Memory and Neural Computing
- Molecular Communication and Nanonetworks
- Advanced Fluorescence Microscopy Techniques
- Cephalopods and Marine Biology
- Memory Processes and Influences
- Neural Networks and Applications
- Cognitive Science and Mapping
- Advanced biosensing and bioanalysis techniques
- Spatial Cognition and Navigation
- Cannabis and Cannabinoid Research
- Electrochemical Analysis and Applications
- Child and Animal Learning Development
Regeneron (United States)
2023-2024
Columbia University
2017-2023
Columbia University Irving Medical Center
2020-2021
Brain (Germany)
2019
New York University
2016-2018
University of Lethbridge
2006-2015
SUNY Downstate Health Sciences University
2013
The time when an event occurs can become part of autobiographical memories. In brain structures that support such memories, a neural code should exist represents or how long ago events occurred. Here we describe neuronal coding mechanism in hippocampus be used to represent the recency experience over intervals hours days. When same is repeated after periods, activity patterns hippocampal CA1 cell populations progressively differ with increasing temporal distances. Coding for space and...
Locomotor speed is a basic input used to calculate one’s position, but where this signal comes from unclear. We identified neurons in the supramammillary nucleus (SuM) of rodent hypothalamus that were highly correlated with future locomotor and reliably drove locomotion when activated. Robust control was specifically
Behavior is used to assess memory and cognitive deficits in animals like Fmr1-null mice that model Fragile X Syndrome, but behavior a proxy for unknown neural events define variables recollection. We identified an electrophysiological signature of recollection mouse dorsal Cornu Ammonis 1 (CA1) hippocampus. During shocked-place avoidance task, slow gamma (SG) (30–50 Hz) dominates mid-frequency (MG) (70–90 oscillations 2–3 s before successful avoidance, not failures. Wild-type (WT) rapidly...
We present evidence that certain learning parameters can make a memory, even very recent one, become independent of the hippocampus. confirm earlier findings damage to hippocampus causes severe retrograde amnesia for context memories, but we show repeated sessions create memory is not vulnerable damage. The demonstrate memories normally dependent on are incrementally strengthened in other networks with additional learning. latter provides new account patterns hippocampal and how may
Abstract Temporal lobe epilepsy (TLE) is characterized by recurrent seizures driven synchronous neuronal activity. The reorganization of the dentate gyrus (DG) in TLE may create pathological conduction pathways for discharges temporal lobe, though critical microcircuit-level detail missing from this pathophysiological intuition. In particular, relative contribution adult-born (abGC) and mature (mGC) granule cells to epileptiform network events remains unknown. We assess dynamics abGCs mGCs...
Training in the active place avoidance task changes hippocampus synaptic function, dynamics of local field potentials, cell discharge, and memory is maintained by persistent PKMζ activity. The extent to which these reflect processes and/or stress responses unknown. We designed a study assess within measuring serum corticosterone (CORT) at different stages training. CORT levels did not differ between trained mice that learned avoid location mild foot shock, untrained no-shock controls exposed...
Damage to the hippocampus (HPC) using excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory. This is typically attributed loss of cells in HPC. However, NMDA also known intense neuronal discharge (seizure activity) during hours that follow its injection. These seizures may have detrimental effects on retrieval memories. Here we evaluate possibility due NMDA-induced seizure activity or cell damage per se. To assess induced memory, developed a lesion...
Context memories normally depend on the hippocampus (HPC) but, in absence of HPC, other memory systems are capable acquiring and supporting these memories. This suggests that HPC can interfere with during acquisition. Here we ask whether also retrieval a context was independently acquired by non-HPC system. Specifically, assess impair contextual fear-conditioning while temporarily inactive. Rats were infused γ-aminobutyric acid (GABA)(A) receptor agonist muscimol dorsal ventral either before...
Abstract Performance in several memory tasks is known to be unaffected by hippocampal damage sustained before learning, but severely disrupted if the same occurs after learning. Memories for preferred locations, or home bases, exploratory can formed rats with damage, it unknown a base survives damage. To examine this question, 30 min each day five consecutive days, explored circular open field containing one local cue. By Day 5 preferentially went directly that location, spent majority of...