A wireless and battery-less trimodal neural interface system-on-chip (SoC), capable of 16-ch recording, 8-ch electrical stimulation, optical all integrated on a 5 × 3 mm

The Internet of Bio-NanoThings (IoBNT) concept envisions the connection between biological cells and Internet. ultimate goal IoBNT is to catalyze a revolution in biomedical technologies through advances molecular communication, integrated systems, bio-nanosensors synthetic biology improve human health quality life. In this paper, an application called PANACEA (a solution or remedy for all difficulties diseases Latin) presented as end-to-end design towards realizing first time literature....

The landscape of miniaturized wireless biomedical devices (MWBDs), including various injectables, ingestibles, implantables, and wearables, is rapidly expanding as proactive mobile healthcare proliferates. While the growth MWBDs increases flexibility medical services, adoption these technologies poses privacy security risks to their users. As a result, while being restricted in resources (size, power, processing, storage), require trust must be at least minimally secure face evolving...

Transcutaneous oxygen monitoring is a noninvasive method for measuring the partial pressure of diffusing through skin, which strongly correlates with changes in dissolved arteries. Luminescent sensing one techniques assessing transcutaneous oxygen. Intensity- and lifetime-based measurements are two well-known methods used this technique. The latter more immune to optical path reflections, making less vulnerable motion artifacts skin color changes. Although promising, acquisition...

A novel random number generation method based on chaotic sampling of regular waveform is proposed. high speed IC truly generator this also presented. Simulation and experimental results, verifying the feasibility circuit, are given. Numerical binary data obtained according to proposed pass four basic tests FIPS-140-2, while full NIST-800-22 test suite without post-processing.

Transcutaneous monitoring is a noninvasive method to continuously measure the partial pressures of oxygen and carbon dioxide that diffuse through skin correlate closely with changes in blood gases. However, contemporary commercially available electrochemical-based technology requires heating mechanism bulky, corded, expensive sensing unit. This study aims demonstrate prototype noninvasive, miniaturized monitor uses luminescence-based pressure transcutaneous oxygen, surrogate arterial oxygen....

Proper operation of active circuits in a wirelessly powered system requires both sufficient power flow and voltage. Passive (battery-less) wireless systems, operating the high-frequency band, pose challenge: generating amount supply voltage from very low-input-power flow. The answer to this problem involves implementation new class power-sipping, multiplying management blocks, which have wide variety applications implantable microelectronic devices (IMD) internet things (IoT) radio-frequency...

In this brief, we present a reconfigurable rectifier, which makes it feasible to harvest energy with net-zero consumption, i.e., without draining power from battery, in wide input range. The proposed topology can operate low signals and be fine-tuned for specific operating frequency range several MHz GHz remotely powered systems. A prototype is fabricated 0.35-μm standard CMOS process occupies 0.019 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

The world has been in combat with COVID-19 since December 2019. United States paralyzed, the highest number of cases and more deaths than any other country. However, disease devastated almost every nation across globe, from Far East to Europe, Latin America, Russia, India. In this article, we cover emerging blood gas monitoring devices techniques create sensors IC structures transform bulky benchtop instruments into miniaturized, next-generation bio-medical devices. We also explore currently...

This paper presents an integrated readout dedicated to sensing transcutaneous oxygen, a first of its kind. The circuit employs fluorescence-based method sense the oxygen molecules diffusing through skin. system uses platinum porphyrin thin film, blue light-emitting diode (LED) that excites and photodiode (PD) captures red light emitted from film. presence quenches intensity lifetime light. (IC), which is in 0.18 μm 5 V CMOS process, film senses current flowing PD. analog front-end converts...

Random Number Generators with logic gates only are popular among digital IC designers in terms of their speed compatibility and uncomplicated integration to platforms. To the best our knowledge, this paper presents first ASIC implementation a Generator based on Fibonacci Galois ring oscillators. Prototypes have been designed fabricated by using HHNEC's 0.25µm eFlash process supply voltage 2.5V. oscillators implemented combined configuration. A configuration, which consists oscillator 16...

Implantable biomedical devices (IMDs) capable of injecting a designated current into target neural tissue to modulate activity have been proven therapeutically effective. The next generation IMDs is expected sense changes in the evoked activities, allowing recorded data be used as feedback mechanism adjust stimulation parameters/patterns, making these systems even more effective while reducing power consumption [1]. Recently, optogenetic neuromodulation with distinct advantages cell-type...

This article presents fundamental challenges in the development of a self-sustainable and biocompatible network infrastructure to interconnect next-generation electrical biological wearable implantable devices, i.e., Internet Bio-NanoThings. The direct contact IoBNT devices with human body, where cells naturally communicate organize into networks, suggests possibility exploit these communications for device-to-device interconnection. aim this work is investigate minimally invasive,...

The partial pressure of arterial carbon dioxide plays a critical role in assessing the acid-base and respiratory status human body. Typically, this measurement is invasive can only be taken momentarily when an blood sample drawn. Transcutaneous monitoring noninvasive surrogate method that provides continuous measure dioxide. Unfortunately, current technology limited to bedside instruments mainly used intensive care units. We developed first-of-its-kind miniaturized transcutaneous monitor...

<?Pub Dtl=""?> In order to maximize randomness of CMOS Ring Oscillators (RO) used in Random Number Generators (RNG), possibility weak inversion operation transistors is investigated. To predict noise performance RO, phase and jitter models a RO operating region are obtained. Differential Oscillator (DRO) Inverter-based (IbRO) cases both For each case, the model covers flicker white component jitter. The derived verified by measurement results. 0.25 <formula formulatype="inline"...

To increase power conversion efficiency (PCE), we introduce a new rectifier, which combines advantages of cross-coupled and bridge rectifiers by switching between the two topologies according to incoming signal level. In conventional designs, topology attains up 80% PCE in low-power range, while mid-power range. Hence, proposed passive rectifier provides minimum 57% entire low- ranges. switch topologies, voltage detector is used sense very low input voltages followed control circuit. The...

Arterial blood gases, oxygen, carbon dioxide, and the potential of hydrogen are key indicators respiratory status should be continuously monitored for patients whose vital signs may alter frequently rapidly. The arterial partial pressure oxygen dioxide can estimated with transcutaneous monitoring, which measures diffusing from skin. However, requiring a heating element large, expensive bedside monitor limitations traditional gas monitors preventing continuous monitoring outside clinical...

Battery-less wireless systems generate their supply voltage from the incoming RF signal, and need to deal with problem of generating sufficient level required by various blocks weak input signals, while maintaining high efficiency. The presented multiplier (VM) seeks maximize power conversion efficiency (PCE) changing RF-to-DC converter topology in VM based on signal. Besides topology, number stages can change for desired output dc varying A prototype is fabricated 0.35-μm standard CMOS...

Monitoring of vital signs and screening at risk patients remotely would improve the outcomes treatment promote outpatient care, which is one main aims modern digital health technology. Among human body, respiration a key component person's health. Respiratory can be quantified by rate, volume, blood-gas content. Traditional monitoring methods such as arterial blood gas pulse oximetry have certain advantages disadvantages. This paper presents prototype demonstration an oxygen sensing platform...

This paper reports on a novel solution for transimpedance amplifier (TIA) specifically designed as an analog conditioning circuit low-voltage, low-power, wearable, portable and implantable optoelectronic integrated sensor systems in biomedical applications. The growing use of sensors all fields industry, biomedicine, agriculture, environment analysis, workplace security safety, needs the development small with reduced number electronic components to be easily standard CMOS technology....

In this work, we formalize a long-felt need in the spectrum sharing community using concept of digital twin, which is maintenance virtual representation properties with near- or quasi-real time updates selected sensing. An immediate consequence formulation for low-cost, widespread sensing technology. We illustrate how emerging technologies RFID and backscatter communications can fill void allow next-generation management technology to flourish.