A5058305889- Methane Hydrates and Related Phenomena
- Bioactive Compounds and Antitumor Agents
- Atmospheric and Environmental Gas Dynamics
- Synthesis and Reactions of Organic Compounds
- Hydrocarbon exploration and reservoir analysis
- Microbial Community Ecology and Physiology
- Arctic and Antarctic ice dynamics
- Beetle Biology and Toxicology Studies
- Synthesis and biological activity
- Morinda citrifolia extract uses
- Geological Studies and Exploration
- Phenothiazines and Benzothiazines Synthesis and Activities
- Food Industry and Aquatic Biology
- Synthesis of Organic Compounds
- Marine and environmental studies
- Synthesis and Characterization of Heterocyclic Compounds
- Geochemistry and Elemental Analysis
- Cryospheric studies and observations
- Geological and Geophysical Studies
- Marine Sponges and Natural Products
- Synthesis and bioactivity of alkaloids
- Synthesis and Biological Evaluation
- Echinoderm biology and ecology
- Microbial bioremediation and biosurfactants
- Microbial Metabolic Engineering and Bioproduction
V.I. Il'ichev Pacific Oceanological Institute
2015-2022
Russian Academy of Sciences
2009-2021
Far Eastern Branch of the Russian Academy of Sciences
2011-2021
Far Eastern Federal University
2016-2017
Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences
2011-2012
A series of 6,7-disubstituted 2-hydroxy-3-nitronaphthazarins were prepared by treatment 2,3-dichloronaphthazarins with sodium nitrite. Acid-catalyzed hydrolysis a mixture two isomeric 6(7)-ethoxy-7(6)-ethyl-substituted 2-hydroxy-3-nitronaphthazarins followed chromatographic separation led to the individually precursors echinamines and B. Further reduction nitroquinones using various reducing agents gave related 3-amino-2-hydroxynaphthazarins in good yields.
New convenient two-step synthesis of natural pigment echinamine A by the condensation 2,3-dichloro-6-ethyl-7-hydroxy-1,4-naphthoquinone with sodium nitrite and subsequent reduction intermediate 7-ethyl-2,5,6,8-tetrahydroxy-3-nitro-1,4-naphthoquinone has been developed.
The article presents data on the distribution of bioindicator thermophilic hydrocarbon-oxidizing microorganisms in surface layer bottom oil and gas bearing sediments Kara Sea their interrelation with methane content. Cultivated capable using hydrocarbons as only carbon source found zone no constant heat flow are indicators deposits. In work, enrichment cultures bacteria were created, which incubated at different temperatures +5, +30 +60 °C. It was that, microbiome is mainly represented by...
Twenty five hydroxy-, chloro- and methoxy derivatives of natural synthetic naphthazarins their acetylated O-glycosides were synthesized. Targeted compounds screened as cytotoxic agents on mouse Ehrlich ascites carcinoma cells using MTT test. Chloro- methoxy-substituted naphthoquinones well naphthoquinone O-acetylglucosides the most potent with IC 50 in low micromolar concentration range. Glucosidation hydroxynaphthoquinones was shown to enhance cytotoxicity, whereas methoxylation yielded...
Fifty natural and synthetic hydroxy-, aminohydroxynaphthazarins related quinones were tested for their antiradical activities using 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) scavenging assay. The main features of structure-antiradical activity relationship amino- hydroxyquinones determined the first time. It was found that naphthazarins (5,8-dihydroxy-1,4-naphthoquinones) are much more active against ABTS-radical than 1,4-naphthoquinones 5-hydroxy-1,4-naphthoquinones. Natural...
Abstract under acidic conditions
Морские донные отложения представляют собой крупнейший резервуар органических веществ на Земле. Биогеохимический цикл метана в воде связывает aнаэробную деструкцию органического вещества с процессами продукции. Этот состоит из образования и окисления метана, которых участвуют специализированные группы микроорганизмов, играющие важную роль глобальном цикле газовом режиме океанов. Метанотрофные микроорганизмы окисляют метан как аэробно, так анаэробно, значительно уменьшая выброс этого...