About
Contact & Profiles
A5086441038
Research Areas
- Erythrocyte Function and Pathophysiology
- Hemoglobin structure and function
- Hemoglobinopathies and Related Disorders
- Blood properties and coagulation
- Neonatal Health and Biochemistry
- Ion channel regulation and function
- Calcium signaling and nucleotide metabolism
University of Leeds
2022-2024
Background and Purpose The protein PIEZO1 forms mechanically activated, calcium‐permeable, non‐selective cation channels in numerous cell types from several species. Options for pharmacological modulation are limited so we modified a small‐molecule agonist at (Yoda1) to increase the ability modulate these channels. Experimental Approach Medicinal chemistry generated Yoda1 analogues that were tested intracellular calcium patch‐clamp assays on cultured cells exogenously expressing human or...
10.1111/bph.15996
article
EN
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British Journal of Pharmacology
2022-12-02
10.1016/j.bpj.2022.11.2162
article
EN
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Biophysical Journal
2023-02-01
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