About
Contact & Profiles
A5041509097
Research Areas
- Autophagy in Disease and Therapy
- RNA regulation and disease
- CRISPR and Genetic Engineering
Broad Institute
2020
Transcription factor EB (TFEB) activates lysosomal biogenesis genes in response to environmental cues. Given implications of impaired TFEB signaling and dysfunction metabolic, neurological, infectious diseases, we aim systematically identify TFEB-directed circuits by examining transcriptional responses subcellular localization stimulation. We reveal that steady-state nuclear is sufficient activate transcription lysosomal, autophagy, innate immunity genes, whereas other targets require higher...
10.1016/j.celrep.2020.108371
article
EN
cc-by
Cell Reports
2020-11-01
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