A5018131284- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Burn Injury Management and Outcomes
- Alcohol Consumption and Health Effects
- Cancer Genomics and Diagnostics
- Appendicitis Diagnosis and Management
- Heme Oxygenase-1 and Carbon Monoxide
- Poisoning and overdose treatments
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Eicosanoids and Hypertension Pharmacology
- Respiratory Support and Mechanisms
- Clinical Nutrition and Gastroenterology
- Aldose Reductase and Taurine
- Cannabis and Cannabinoid Research
- Adipokines, Inflammation, and Metabolic Diseases
- Neurofibromatosis and Schwannoma Cases
- Thermal Regulation in Medicine
- Gastrointestinal Tumor Research and Treatment
- Wound Healing and Treatments
- Stoma care and complications
- Congenital Anomalies and Fetal Surgery
- NF-κB Signaling Pathways
Fox Chase Cancer Center
2019-2022
Loyola University Medical Center
2014-2018
Loyola University Chicago
2014-2017
Burn Institute
2014
Tumor mutational burden (TMB) has recently been identified as a biomarker of response to immune checkpoint inhibitors in many cancers, including melanoma. Co-assessment TMB with inflammatory markers and genetic mutations may better predict disease outcomes. The goal this study was evaluate the potential for somatic combination recurrence advanced A retrospective review 85 patients stage III or IV melanoma whose tumors were analyzed by next-generation sequencing conducted. Fisher’s exact test...
Of the 450,000 burn patients each year, 50% have a positive blood alcohol content, and this predisposes them to worsened clinical outcomes. Despite high prevalence established consequences, mechanisms responsible for alcohol-mediated complications of postburn remote organ damage are currently unknown. To end, mice received single dose (1.12 g/kg) or water by oral gavage were subjected 15% total body surface area burn. Animals with alone lost ∼5% their weight in 24 h, whereas intoxicated...
Clinical and animal studies demonstrate that alcohol intoxication at the time of injury worsens postburn outcome. The purpose this study was to determine role mechanism Kupffer cell derangement in exacerbating end organ damage alcohol-exposed mice.Interventional study.Research Institute.Male C57BL/6 mice.Alcohol administered 30 minutes before a 15% scald burn injury. Antecedent depletion with clodronate liposomes (0.5 mg/kg). p38 mitogen-activated protein kinase inhibition via SB203580 (10...
Abstract Background Few studies have evaluated outcomes of total neoadjuvant therapy (TNT) compared with single modality (SMNT) or surgery first (SF) for pancreatic ductal adenocarcinoma (PDAC). Methods A single‐institution retrospective review PDAC patients who underwent pancreatectomy was conducted (1993–2019). Overall survival (OS) estimates from diagnosis and were determined using Kaplan–Meier methods; Cox proportional hazards models adjusted covariates. Results Surgery performed upfront...
Alcohol intoxication precedes half of adult burn injuries and leads to worsened clinical outcomes. We recently reported before alters the gut‐liver axis which drives pulmonary inflammation through interleukin‐6 (IL‐6) we now seek determine mechanisms this aberrant response. C57/BL6 mice were given ethanol (1.2 g/kg) by oral gavage 30 min prior a 15% scald burn. Depletion Kupffer cells (KCs) was achieved with clodronate liposomes (0.5 mg/kg). KCs isolated analyzed for p38 MAPK ± LPS...
700 Background: Malnutrition and malignant bowel obstruction (MBO) are common consequences of advanced malignancy. Both lead to a poor prognosis, frequent hospitalizations, have negative impact on quality life. The aim this study is explore gastrostomy tube (g-tube) placement practices better define the role g-tube in Methods: Patients who underwent at our tertiary cancer care center between 2013 2017 were included study. Patients’ demographics, diagnosis, procedures, postoperative course,...
Introduction: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS/HIPEC) has led to improved survival in select patients with peritoneal surface malignancies. Predicting the volume of disease any unresectable is important for determining CS candidacy. Computed tomography (CT) scan preoperative assessment choice, diagnostic laparoscopy (DL) also supported literature but not been widely adopted. In this study, we report our experience comparing evaluating role imaging DL...
646 Background: Multiple studies have shown the superiority of biliary metal compared with plastic stents for pre-operative (preop) drainage in pancreatic cancer (PDAC). Despite importance preop cross-sectional imaging, particularly era neoadjuvant treatment, there is no data on impact such quality imaging. We hypothesis, that negatively accuracy imaging cancer, unknown adequacy surgical candidacy. Methods: Data all patients undergoing resection PDAC between 1/1/2012 and 1/1/2018 was...