A5012995073- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Coffee research and impacts
- Ubiquitin and proteasome pathways
- Microbial metabolism and enzyme function
- Viral gastroenteritis research and epidemiology
- Diet and metabolism studies
- Influenza Virus Research Studies
- Hair Growth and Disorders
- Spaceflight effects on biology
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- High Altitude and Hypoxia
- Skin and Cellular Biology Research
- Biochemical effects in animals
- Carbohydrate Chemistry and Synthesis
- Biosensors and Analytical Detection
- Bacteriophages and microbial interactions
- Bacterial Identification and Susceptibility Testing
- Pharmacology and Obesity Treatment
Southern University of Science and Technology
2021-2024
Institute of Microbiology
2024
Chinese Academy of Sciences
2024
Beijing Institute of Technology
2020-2021
Pseudomonas aeruginosa (PA) is a leading cause of hospital-acquired and ventilator-associated pneumonia. The multidrug-resistance (MDR) rate PA increasing making the management global challenge. Messenger RNA (mRNA) vaccines represent most promising alternative to conventional are widely studied for viral infection cancer immunotherapy while rarely bacterial infections. In this study, two mRNA encoding PcrV- key component type III secretion system in fusion protein OprF-I comprising outer...
Notwithstanding the presence of a smallpox vaccine that is effective against monkeypox (mpox), developing universal candidate virus (MPXV) highly required as mpox multi-country outbreak has increased global concern. MPXV, along with variola (VARV) and vaccinia (VACV), belongs to Orthopoxvirus genus. Due genetic similarity antigens in this study, we have designed potentially mRNA based on conserved epitopes are specific these three viruses. In order design vaccine, A29, A30, A35, B6, M1 were...
mRNA vaccines have become a promising alternative to conventional cancer immunotherapy approaches. However, its application on colorectal (CRC) remains poorly understood. We herein identified potential antigens for designing an effective vaccine, further build immune landscape the accurate selection of patients vaccine therapy. Raw transcriptome data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were retrieved. Consensus clustering algorithm was applied...
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is undoubtedly the most challenging pandemic in current century and remains a global health emergency. As number of COVID-19 cases world on rise variants continue to emerge, there an urgent need for vaccines. Among all immunization approaches, mRNA vaccines have demonstrated more promising results response this challenge. Herein, we designed mRNA-based vaccine encoding receptor-binding...
MicroRNAs (miRNAs) with nucleotides are a class of endogenous small RNAs and can play crucial functions in diagnosing diseases.
Monkeypox (mpox) is a zoonotic infectious disease caused by the mpox virus. Mpox symptoms are similar to smallpox with less severity and lower mortality. As yet virus not characterized as high transmissibility some severe acute respiratory syndrome 2 (SARS-CoV-2) variants, still, it spreading, especially among men who have sex (MSM). Thus, taking preventive measures, such vaccination, highly recommended. While vaccine has demonstrated considerable efficacy against due antigenic similarities,...
Despite the existence of various types vaccines and involvement world’s leading pharmaceutical companies, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains most challenging health threat in this century. Along with increased transmissibility, new strains continue to emerge need for more that would elicit protectiveness safety against virus. Nucleic acid seem be effective approach case a sudden outbreak infection or emergence strain as it requires less time than any...
Aluminum corrosion has become a major obstacle in spacecraft construction given that aluminum is used extensively throughout the process. Despite its many attributes strength and durability, susceptible to corrosion, particular, due microbial contamination. Scientists have encountered number of problems with within components. Here, we summarize recent findings regard phenomenon microbiologically influenced (MIC) on space stations context strains isolated from Mir station (Mir) International...
Cervical cancer is one of the most common malignancies in women with high morbidity and mortality. Human papillomavirus (HPV) infection primary cause cervical cancer, which HPV 16 predominant. Early detection effective treatment precancerous lesions are key to preventing cancer. Vitamin D receptor (VDR) gene polymorphism considered be an important development. Here, we studied association VDR polymorphisms (FOKI, BsmI, ApaI, TaqI) HPV16-positive intraepithelial neoplasia (CIN)2+ patients....
Breast cancer is considered the most prevalent malignancy due to its high incidence rate, recurrence, and metastasis in women that makes it one of deadliest cancers. The current study aimed predict genes associated with recurrence breast validate their effect on MDA-MB-231 cells. Through bioinformatics analysis, transcription factor 7 cofactor (MLLT11) as target gene was obtained. MLLT11-specific siRNA synthesized transfected into results demonstrated significantly reduced MLLT11 mRNA...
Abstract Corrosion of aluminium (Al) is a potential problem for spacecraft as this metal used various mechanical parts due to its strength, durability, etc. However, it can be corroded by certain factors including microbes. Studying microbes which implicated in microbiologically influenced corrosion (MIC) their extremophilic nature vital importance. In current study, Al and acid-tolerant were isolated from the samples China space station assembly cleanroom surfaces; acidic environments...
Aldose reductase (ALR2) plays a pivotal role in the development of diabetic complications. ALR2 inhibitors (ARIs) have proven efficient to prevent and delay chronic diseases, thus attracted significant research interest. This article reviews series aromatic heterobicyclics-based ARIs developed over recent years, discusses about their structure-activity relationships as well multifunctionalities such antioxidant property