A5046861579- Antibiotics Pharmacokinetics and Efficacy
- Healthcare Regulation
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Public Health in Brazil
- Sepsis Diagnosis and Treatment
- Poisoning and overdose treatments
- Streptococcal Infections and Treatments
- Neonatal Health and Biochemistry
- Thermal Regulation in Medicine
- Antibiotic Resistance in Bacteria
- Burn Injury Management and Outcomes
- Microbial infections and disease research
- Immunodeficiency and Autoimmune Disorders
- Neonatal and Maternal Infections
- Respiratory Support and Mechanisms
- Bacterial Identification and Susceptibility Testing
- Environmental and biological studies
Universidade de São Paulo
2021-2024
Meropenem is largely prescribed to septic patients with severe infections caused by gram-negative nosocomial pathogens Enterobacteriaceae (fermenters, EB) and Non-Enterobacteriaceae (non-fermenters, NEB).Pharmacokinetics (PK) changes reported previously in burns can affect the desired outcome physiopathology alterations during systemic inflammatory response syndrome.The study aimed investigate if target attained burn patients' adolescents versus young adults receiving same recommended...
Introduction:In view of the growing challenge to use antimicrobials for adequate and effective therapy nosocomial infections, international health agencies have reinforced that combating bacterial resistance preventing development multidrug-resistant (MDR) strains are urgent, since hospital infection control committees reported a significant increase in minimum inhibitory concentration (MIC) therapeutic agents against pathogens.Meropenem piperacillin-tazobactam largely prescribed septic...
AUC ss 0-24 ,area under the curve; / MIC>400, area curve: MIC ratio higher than 400 up to 600 (Vancomycin PK/PD target); 100% f∆T>MIC, time dose interval that free drug serum levels is (Meropenem PK/ PD CSLI, clinical standard laboratory institute, database USA; GSA,
Abordagem farmacocinética-farmacodinâmica (PK/PD) na avaliação da efetividade do Meropenem em pacientes sépticos queimados adolescentes versus adultos
Introduction:In view of the growing challenge to use antimicrobials for adequate and effective therapy hospital infections, international health agencies have reinforced that it is urgent combat bacterial resistance in preventing development multidrug-resistant (MDR) strains.There has been a significant increase minimum inhibitory concentration (MIC) most available prescribed therapeutic agents against pathogens based on reports this occurrence by infection control committees.Currently,...
Introduction: Faced with the growing challenge to use of antimicrobials for adequate and effective therapy nosocomial infections, international health agencies have reinforced that combating bacterial resistance preventing development multidrug-resistant (MDR) strains are urgent, since a significant increase based on minimum inhibitory concentration (MIC) therapeutic agents were reported by committee hospitals infection. Meropenem, carbapenem agent, is widely prescribed septic shock caused...
Introduction: Septic shock is one of the leading causes death among critically ill patients in Intensive Care Unit (ICU), including severely major burned patients. Rapid diagnosis and early initiation effective antimicrobial therapy are main challenges. The role leukocytes as neutrophil/lymphocyte ratio (NLR) various systemic inflammatory indices, include serum levels interleukin-6 (IL-6), procalcitonin (PCT) c-reactive protein (c-RP) informative laboratory markers this regard respect....
Introduction:Optimizing antimicrobial prescription for severe infections is a challenge in Intensive Care Units critically ill patients to improve clinical outcome.Aim of the study was evaluate drug effectiveness septic pediatric burn undergoing combined therapy with vancomycin and meropenem.Methods: Pediatric receiving meropenem were included (7F/10M).Characteristics patient's population, expressed by minimum/maximum values were: 3.1/11.2yrs; 12/44 kg; 11/75% TBSA; SCr: 0.15/0.47mg/dL;...
O regime de dose empírica vancomicina recomendado geralmente não atinge o alvo terapêutico em pacientes sépticos estado crítico da Unidade Terapia Intensiva (UTI) contra as cepas mais comuns Gram-positivos CIM> 1 mg/L podendo impactar desfecho clínico desejado. objetivo do estudo foi comparar empírico g q12h com q8h base na abordagem farmacocinética-farmacodinâmica (PK/PD) queimados terapia intensiva. Após a aprovação ética e termo consentimento assinado pelos responsáveis cada paciente...
O regime de dose empírica recomendado Vancomicina frequentemente não atinge o alvo terapêutico em pacientes sépticos críticos Unidade Terapia Intensiva (UTI) contra as cepas mais comuns Gram positivos com CIM> 1 mg/L, podendo impactar no desfecho clínico desejado. objetivo do trabalho foi comparar ajustada base na individualização da terapia antimicrobiana pela abordagem farmacocinética-farmacodinâmica (PK/PD) nos oncológicos função renal preservada intensiva. estudo recebeu aprovação ética...