A5075547178- Antibiotics Pharmacokinetics and Efficacy
- Burn Injury Management and Outcomes
- Wound Healing and Treatments
- Poisoning and overdose treatments
- Antibiotic Use and Resistance
- Healthcare Regulation
- Nosocomial Infections in ICU
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Injury Epidemiology and Prevention
- Public Health in Brazil
- Advancements in Transdermal Drug Delivery
- Reconstructive Surgery and Microvascular Techniques
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Environmental and biological studies
- Anesthesia and Sedative Agents
- Inhalation and Respiratory Drug Delivery
- Clostridium difficile and Clostridium perfringens research
- Anesthesia and Neurotoxicity Research
- Streptococcal Infections and Treatments
- Respiratory Support and Mechanisms
- Skin Protection and Aging
- Neutropenia and Cancer Infections
- Reconstructive Facial Surgery Techniques
Universidade de São Paulo
2005-2024
Universidad Autónoma de Madrid
2024
Hospital de León
2024
Hospital de Clínicas de Porto Alegre
2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2009-2022
Ibero American University
2022
Hospital de Clínicas
2021
Creative Commons
2021
Sociedade Brasileira de Cirurgia Plástica
2012
Skin grafting is the single most effective method to close a chronic wound. The current standard of care use meshed split thickness skin grafts. This entails surgical instruments that need be autoclaved and have power source, which usually requires an OR facility. minced technique uses use, presterilized procedure can done under local anesthesia, by wound practitioner, in clinic, physician's office or even at bedside. study was designed determine if results from micrografting were non...
65(2):237-43 Fluconazole plasma concentration measurement by liquid chromatography Santos SRCJ et al.in burn patients, probably as a consequence of important changes in their pharmacokinetics.This may explain drug accumulation over time.Therapeutic monitoring will be useful long-term antifungal therapy patients to maintain clinical efficacy.High variability levels these time can expected.
Thermal injuries and injured areas management are important causes of pain in burned patients, requiring that these patients constantly undergoing general anesthesia for dressing change. Nitrous oxide (N2O) has analgesic sedative properties; it is easy to use widely available. Thus, the aim this study was evaluate effect N2O combined with fentanyl during After approval by institutional Ethics Committee, 15 adult daily change were evaluated. Patient analgesia controlled 0.0005% administered...
Meropenem is largely prescribed to septic patients with severe infections caused by gram-negative nosocomial pathogens Enterobacteriaceae (fermenters, EB) and Non-Enterobacteriaceae (non-fermenters, NEB).Pharmacokinetics (PK) changes reported previously in burns can affect the desired outcome physiopathology alterations during systemic inflammatory response syndrome.The study aimed investigate if target attained burn patients' adolescents versus young adults receiving same recommended...
INTRODUÇÃO: O objetivo deste estudo é descrever a experiência da Unidade de Tratamento Queimados Divisão Cirurgia Plástica do Hospital das Clínicas Faculdade Medicina Universidade São Paulo (HCFMUSP), em 15 meses consecutivos, no atendimento às crianças queimadas. MÉTODO: Foram analisados os dados 98 pacientes, com idade < 13 anos, atendidos na HCFMUSP, outubro 2009 dezembro 2010. RESULTADOS: A média atendidas foi 5,2 sendo 67 (68,4%) sexo masculino. Os acidentes foram responsáveis por 93...
Introduction:In view of the growing challenge to use antimicrobials for adequate and effective therapy nosocomial infections, international health agencies have reinforced that combating bacterial resistance preventing development multidrug-resistant (MDR) strains are urgent, since hospital infection control committees reported a significant increase in minimum inhibitory concentration (MIC) therapeutic agents against pathogens.Meropenem piperacillin-tazobactam largely prescribed septic...
AUC ss 0-24 ,area under the curve; / MIC>400, area curve: MIC ratio higher than 400 up to 600 (Vancomycin PK/PD target); 100% f∆T>MIC, time dose interval that free drug serum levels is (Meropenem PK/ PD CSLI, clinical standard laboratory institute, database USA; GSA,
O trabalho descreve o metodo bioanalitico para a quantificacao de meropenem no plasma atraves da cromatografia liquida. Os resultados obtidos indicam optima recuperacao absoluta (>90 por cento), boa linearidade (0,2-50,0 μg/mL, r2=0,999), alta sensibilidade (LQ: 0,2 μg/mL; LD: 0,1 μg/mL) e adequada estabilidade. Registou-se precisao (inter-dia/intra-dia: 2,3%/2,0%) exactidao, 98,9 cento. trabalho reporta caso um doente pediatrico grande queimado, oito anos, 30 kg, lesao termica/inalatoria,...
Myofibroblasts and the contraction of split skin-graft donor sites were studied in 18 patients. For each patient five samples studied, taken on days 0, 14, 21, 28, 35. On occasion extensions densities myofibroblasts calculated. After initial measurement, subsequent expressed percentages first, resulting mean measurements 100, 95, 97, 99, 99%, respectively. The 10 dermic fields counted under light microscopy at a magnification 1000 marked with anti-alpha-smooth muscle actin antibodies using...
<p>A bioanalytical method was developed and applied to quantify the free imipenem concentrations for pharmacokinetics PK/PD correlation studies of dose adjustments required maintain antimicrobial effectiveness in pediatric burn patients. A reverse-phase Supelcosil LC18 column (250 x 4.6 mm 5 micra), binary mobile phase consisting 0.01 M, pH 7.0 phosphate buffer acetonitrile (99:1, v/v), flow rate 0.8 mL/min, applied. The showed good absolute recovery (above 90%), linearity (0.25-100.0...
Thermal injuries and injured areas management are important causes of pain in burned patients, requiring that these patients constantly undergoing general anesthesia for dressing change. Nitrous oxide (N2O) has analgesic sedative properties; it is easy to use widely available. Thus, the aim this study was evaluate effect N2O combined with fentanyl during change.After approval by institutional Ethics Committee, 15 adult daily change were evaluated. Patient analgesia controlled 0.0005%...
Summary: Morel-Lavallée lesion (MLL) is a closed degloving soft-tissue injury that results in the accumulation of hemolymphatic fluid between skin/superficial fascia and deep fascia. This rare may be challenging to diagnose, necessitates early identification treatment achieve best outcomes. We report case 45-year-old male patient who was referred our institution for large wound closure after undergoing debridement misdiagnosed MLL became complicated by infection sepsis. The retrospectively...
Two different and interrelated steps are involved in the assessment of active sweat glands: stimulation sweating its subsequent recording quantification. Sweat activation has been promoted by simple thermal stimulation, intradermal injection drugs such as methylcholine, dermal introduction using iontophoresis. Gibson Cooke’s device for iontophoresis, one most employed devices, provides DC current uses large lead electrodes lined with porous material. The positive pole is dampened 2% [...]
Abordagem farmacocinética-farmacodinâmica (PK/PD) na avaliação da efetividade do Meropenem em pacientes sépticos queimados adolescentes versus adultos