A5032215108- Antifungal resistance and susceptibility
- Vector-borne infectious diseases
- Essential Oils and Antimicrobial Activity
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Fungal Infections and Studies
- Coenzyme Q10 studies and effects
- Mosquito-borne diseases and control
- Microbial Natural Products and Biosynthesis
- Diagnosis and treatment of tuberculosis
- Click Chemistry and Applications
- Medicinal Plants and Neuroprotection
- Piperaceae Chemical and Biological Studies
- bioluminescence and chemiluminescence research
- Cancer therapeutics and mechanisms
- Pharmacology and Nanomedicine Research
- Nematode management and characterization studies
- Insect and Pesticide Research
- Sesame and Sesamin Research
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Tuberculosis Research and Epidemiology
Texas A&M University
2024
Amity University
2017
Lyme disease (LD) caused by Borrelia burgdorferi is among the most important human vector borne diseases for which there no effective prevention method. Identification of tick saliva transmission factors LD agent needed before highly advocated antigen-based vaccine could be developed. We previously reported conserved Ixodes scapularis ( Ixs ) serpin (S) 17 S17) was secreted B . infected nymphs. Here, we show that S17 promote feeding and enhances colonization host. not part a redundant...
This study explored the antifungal potential of perillyl alcohol (PA), a natural monoterpene alcohol, against most prevalent human fungal pathogen C. albicans, its clinical isolates and four non-albicans species Candida. To resolve mechanisms, we used whole genome transcriptome analyses PA treated Candida cells to examine affected cellular circuitry this pathogen. The data revealed link between calcineurin signaling as among several categories responsive genes down regulation gene CNB1 was...
We investigated the antifungal effects of sesamol (Ses), a natural phenolic compound, and exemplified that it could be mediated through disruption calcineurin signaling pathway in C. albicans, human fungal pathogen. The repertoire activity not only was limited to albicans its six clinical isolates tested but also against non-albicans species Candida. Interestingly, effect Ses affects neither MDR efflux transporter nor passive diffusion drug. found treated with copies phenotype displayed by...
Citronellal (Cit) possesses antifungal activity and has possible implications for reactive oxygen species (ROS) generation in Candida albicans. In this study, the effects of Cit on ROS mechanisms by which exerts anti-Candida were examined.A 2',7'-dichlorodihydrofluorescein diacetate assay was used to assess oxidative damage. Cell necrosis determined flow cytometry after FITC-Annexin V staining. Mitochondrial function studied based mitochondrial potential, metabolic (MTT assay), phenotypic...
Candida albicans is known to cause infections ranging from superficial and systemic in immunocompromised person. In this study, we explored that the antifungal action of Methylene blue (MB) mediated through mitochondrial dysfunction disruption redox membrane homeostasis against C. albicans. We demonstrated MB displayed its potential two clinical isolates tested. also showed effective non- species as well. Notably, effect seems be independent major drug efflux pumps transporter activity....
Significance of methylene blue (MB) in photodynamic therapy against microbes is well established. Previously, we have reported the antifungal potential MB Candida albicans . The present study attempts to identify additional antimicrobial effect another prevalent human pathogen, Mycobacterium tuberculosis (MTB). We explored that efficiently inhibiting growth at 15.62 μ g/ml albeit bacteriostatic manner similar its fungistatic nature. uncovered cell surface phenotypes (colony morphology and...
Ixodes scapularis is a blood-feeding obligate ectoparasite responsible for transmitting the Lyme disease (LD) agent, Borrelia burgdorferi. During feeding process, I. injects B. burgdorferi into host along with its saliva, facilitating transmission and colonization of LD agent. Tick calreticulin (CRT) one earliest tick saliva proteins identified currently utilized as biomarker bites. Our recent findings revealed elevated levels CRT in proteome burgdorferi-infected nymphs compared to...
<p class="ADMETabstracttext">The prevalence of fungal infections and their resistance patterns in isolates from large number patients with impaired immunity still remains poorly monitored. In spite significant advances being made the improvement antifungal drugs, only a limited drugs are currently available. The present study aimed to gain further mechanistic insights into previously described anticandidal activity natural monoterpenoid, perillyl alcohol (PA). We found that cellular...
Ixodes scapularis is a blood-feeding obligate ectoparasite responsible for transmitting the Lyme disease (LD) agent, Borrelia burgdorferi. During feeding process, I. injects B. burgdorferi into host along with its saliva, facilitating transmission and colonization of LD agent. Tick calreticulin (CRT) one earliest tick saliva proteins identified currently utilized as biomarker bites. Our recent findings revealed elevated levels CRT in proteome burgdorferi-infected nymphs compared to...