A5060393537- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Essential Oils and Antimicrobial Activity
- Vibrio bacteria research studies
- Medicinal Plants and Neuroprotection
- Phytochemicals and Medicinal Plants
- Pneumocystis jirovecii pneumonia detection and treatment
- Phytochemistry and Biological Activities
- Food Science and Nutritional Studies
- Plant Pathogens and Fungal Diseases
- Enzyme Production and Characterization
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- Trace Elements in Health
- Burkholderia infections and melioidosis
- Plant Disease Management Techniques
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Ethnobotanical and Medicinal Plants Studies
- Salmonella and Campylobacter epidemiology
- Probiotics and Fermented Foods
- Pharmaceutical and Antibiotic Environmental Impacts
- Drug Transport and Resistance Mechanisms
- Digestive system and related health
- Erythropoietin and Anemia Treatment
Dr. Hari Singh Gour University
2023
Amity University
2020-2022
National Institute of Technology Meghalaya
2022
SRM Institute of Science and Technology
2021
Walter Reed Army Institute of Research
2014-2020
Vellore Institute of Technology University
2020
Institute of Microbial Technology
2019
Council of Scientific and Industrial Research
2019
King George's Medical University
2019
University of Minho
2018
ABSTRACT Staphylococcus aureus is a Gram-positive pathogen that causes diverse range of bacterial infections. Invasive S. strains secrete an extensive arsenal hemolysins, immunomodulators, and exoenzymes to cause disease. Our studies have focused on the secreted enzyme hyaluronidase (HysA), which cleaves hyaluronic acid polymer at β-1,4 glycosidic bond. In study described in this report, we investigated regulation contribution pathogenesis. Using Nebraska Transposon Mutant Library (NTML),...
Background. Severe Acinetobacter baumannii infections in immunocompetent patients are uncommon, and the virulence mechanisms of this organism not fully understood. Methods. Following an outbreak fatal A. a cohort relatively (low comorbidity illness severity scores), isolates were investigated with comparative genomics animal models. Results. Two unrelated clades associated outbreak. The clone majority patient deaths, clade B, is evolutionarily distinct from 3 international clonal complexes,...
Among the several mechanisms of multidrug resistance (MDR), overexpression drug efflux pumps CaCdr1p and CaMdr1p belonging to ATP binding cassette (ABC) major facilitator superfamily (MFS) respectively remain predominant candidal infections. Therefore inhibiting or modulating function these transporters continues draw attention as effective strategy combat MDR. We have previously reported antifungal potential Geraniol (Ger), a natural monoterpenoid from Palmarosa oil, against Candida...
There is an increasing burden of multidrug resistance. As a result, deciphering the mechanisms action natural compounds with antifungal activity has gained considerable prominence. We aimed to elucidate probable mechanism citronellal, monoterpenoid found in essential oil extracted from Cymbopogon plants, against Candida albicans.Drug susceptibility was measured by broth microdilution and spot assays. Ergosterol levels were estimated using alcoholic potassium hydroxide method H+ extrusion...
Acinetobacter baumannii is often highly drug-resistant and causes severe infections in compromised patients. These can be life threatening due to limited treatment options. Copper inherently antimicrobial increasing evidence indicates that copper containing formulations may serve as non-traditional therapeutics against multidrug-resistant bacteria. We previously reported A. sensitive high concentrations of copper. To understand resistance at the molecular level, herein we identified putative...
These are some interesting times to be alive as humans and the most versatile curious layer "The Homo Sapiens" of this pale blue planet "Earth" that we all call home in large ever expanding sea cosmos, an unknown race just like a particle chili flakes pizza, timid our behavior always chewing more than can actually swallow ---. There is something about happen, well guess what it has already started time will change everything. What one trait defines defies "Humans" from other species take...
Citronellal (Cit) possesses antifungal activity and has possible implications for reactive oxygen species (ROS) generation in Candida albicans. In this study, the effects of Cit on ROS mechanisms by which exerts anti-Candida were examined.A 2',7'-dichlorodihydrofluorescein diacetate assay was used to assess oxidative damage. Cell necrosis determined flow cytometry after FITC-Annexin V staining. Mitochondrial function studied based mitochondrial potential, metabolic (MTT assay), phenotypic...
The loss of fitness in colistin-resistant (CR) Acinetobacter baumannii was investigated using longitudinal isolates from the same patient. Early CR were outcompeted by late for growth broth and survival lungs mice. Fitness associated with an increased susceptibility to oxidative stress since early strains had reduced vitro presence hydrogen peroxide decreased catalase activity compared that colistin-susceptible (CS) strains.
A critical facet of mammalian innate immunity involves the hosts' attempts to sequester and/or limit availability key metabolic products from pathogens. For example, nutritional encompasses host approaches heavy metal ions such as zinc and iron. Previously, we identified several hundred genes in a multidrug-resistant isolate Acinetobacter baumannii that are required for growth survival Galleria mellonella infection model. In present study, further characterize one these genes, LysR family...
It is rightly proclaimed that "there are patterns in everything." so does apply symmetry between the "human brain neurons and it's simulation artificial neural network". ANN just simply software implementations of neuronal structures our brains. Now network ideological brains "made star dust" a hugely interconnected neurons, like interconnection galaxies universe observable homo-species, brain. Now, on technical terms networks attempted to mimic learn about given specific task basis weighted...
This article focuses on the crucial role of predictive modeling, particularly powered by artificial intelligence (AI), in optimizing power consumption machining, a vital facet modern manufacturing. Highlighting growing significance utilization machining operations due to economic, environmental, and equipment-related implications, underscores importance this area. It proceeds discuss contributions modelling , elucidating its capacity predict manage variability, optimize tool selection...
The present study aimed at evaluating the in vitro of antioxidant activity crude extracts (methanol, acetone, ethyl acetate and chloroform) stem leaves physalis minima.The was determined by two methods DPPH (1, 1-diphenyl-2-picryl hydroxyl) assay reducing power assay.The free radical scavenging minima different concentration (200 µg, 400 600 µg 800 µg).The entire tested sample showed lower than standard.The effect eight leaf decreased order Methanol extract > Acetone Ethyl Chloroform...
Plants have been the basis of many traditional medicines throughout world for thousands years and continued to provide new remedies mankind. They are one richest sources bioactive compounds. The genus Passiflora L. comprises about 520 species dicotyledonous plants in family Passifloraceae. incarnata P. alata, also commonly known as Passion flower, two a perennial climbing vine with beautiful exotic flowers delicious fruit that grow worldwide, preferring subtropical, frost-free climates....