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Alfredo Ruiz-Rivera

ORCID: 0000-0002-4823-8056
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About
Contact & Profiles
A5107508335
Research Areas
  • Ubiquitin and proteasome pathways
  • DNA Repair Mechanisms
  • Cancer-related Molecular Pathways

California State University, San Bernardino
 2025

 Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein (Rb) pocket domain
OPENALEX - Publications 
Anthony E. Castro Alfredo Ruiz-Rivera Chad C Moorman Emma R Wolf-Saxon Hailey N Mims and 9 more Vanessa I Vasquez-Meza Matthew A Rangel Marcos M Loera I. H. Bond Seth B Buchanan Estela Villarreal Sarvind Tripathi Seth M. Rubin Jason R. Burke

10.1016/j.jbc.2025.108284 article EN cc-by Journal of Biological Chemistry 2025-02-01
 Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein (Rb) pocket domain
OPENALEX - Publications 
Anthony E. Castro Alfredo Ruiz-Rivera Chad C Moorman Emma R Wolf-Saxon Hailey N Mims and 9 more Vanessa I Vasquez-Meza Matthew A Rangel Marcos M Loera I. A. Bond Seth B Buchanan Estela Villarreal Sarvind Tripathi Seth M. Rubin Jason R. Burke

The retinoblastoma tumor suppressor (Rb) is a multifunctional protein that primarily regulates the cell cycle but also has roles in cellular differentiation, DNA damage response and apoptosis. loss of Rb key event development or progression many cancers. Essential functions occur through its pocket domain, which necessary for regulating binding interactions with E2F transcription factors repressors bind via an LxCxE motif. domain most highly-conserved region multidomain protein, as well...

10.1101/2024.09.22.614354 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-09-22
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