A5001494993- HER2/EGFR in Cancer Research
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Particle Dynamics in Fluid Flows
- Receptor Mechanisms and Signaling
- Advanced Decision-Making Techniques
- Estrogen and related hormone effects
- Gas Sensing Nanomaterials and Sensors
- Catalytic Processes in Materials Science
- Fluid Dynamics and Turbulent Flows
- Hydraulic and Pneumatic Systems
- Aerodynamics and Acoustics in Jet Flows
- Ship Hydrodynamics and Maneuverability
- Granular flow and fluidized beds
- Distributed and Parallel Computing Systems
- Embedded Systems and FPGA Applications
- Cavitation Phenomena in Pumps
- Software System Performance and Reliability
- Embedded Systems and FPGA Design
- Advanced Photocatalysis Techniques
- Evaluation Methods in Various Fields
- Fluid Dynamics and Heat Transfer
Zymeworks (Canada)
2024
East China University of Science and Technology
2004-2022
Harbin Engineering University
2020
Abstract In recent years, the field of antibody drug conjugates (ADC) has seen a resurgence, largely driven by clinical benefit observed in patients treated with ADCs incorporating camptothecin-based topoisomerase I inhibitor payloads. Herein, we present development novel camptothecin ZD06519 (FD1), which been specifically designed for its application as an ADC payload. A panel analogs different substituents at C-7 and C-10 positions core was prepared tested vitro. Selected compounds...
The Large Eddy Simulation (LES) method was used to study the interaction between propeller wake and a rudder. INSEAN E779A NACA0020 rudder were used, Q−Criterion employed analyse vortices. evolution of propeller-wake in oblique flows effect on vortex studied. pulsating pressures surface for different oblique-flow angles compared. results show that hydrodynamic coefficients increased under flows. shifted as angle changed, but it did not completely coincide with angle. Under effects...
Dispersion characteristics in a dense gas–particle coaxial jet for different cross angles are experimentally investigated through high-speed photography. Because the angle creates radial component of annular gas, contraction granular from central channel is observed. The minimum diameter and length decrease with increases gas velocity angle. A phase diagram dispersion modes obtained. Moreover, function velocity, particle mass flow rate, highly nonmonotonic velocity. Finally, enhances...
<p>Supplementary Figure S2 shows the chemical stability of FD1 (ZD06519)</p>
<p>Supplementary Figure S3 shows the in vitro cytotoxicity assessment of trastuzumab-ADCs both two-dimensional (2D) and three-dimensional (3D) spheroid assays</p>
<p>Synthesis and characterization of free drugs drug-linkers</p>
<p>Supplementary Figure S4 shows the pharmacokinetic analysis of ADCs (total antibody PK) from tolerability study in rats</p>
<p>Supplementary Figure S4 shows the pharmacokinetic analysis of ADCs (total antibody PK) from tolerability study in rats</p>
<p>Synthesis and characterization of free drugs drug-linkers</p>
<p>HPLC-HIC, LC-MS, HPLC-SEC, residual free drug analysis, and endotoxin levels of ADCs</p>
<div>Abstract<p>In recent years, the field of antibody drug conjugates (ADC) has seen a resurgence, largely driven by clinical benefit observed in patients treated with ADCs incorporating camptothecin-based topoisomerase I inhibitor payloads. Herein, we present development novel camptothecin ZD06519 (FD1), which been specifically designed for its application as an ADC payload. A panel analogs different substituents at C-7 and C-10 positions core was prepared tested <i>in...
<p>Supplementary Figure S3 shows the in vitro cytotoxicity assessment of trastuzumab-ADCs both two-dimensional (2D) and three-dimensional (3D) spheroid assays</p>
<p>Supplementary Figure S1 shows the murine plasma stability of T-DL4 and T-DL13</p>
<p>Supplementary Figure S1 shows the murine plasma stability of T-DL4 and T-DL13</p>
<div>Abstract<p>In recent years, the field of antibody drug conjugates (ADC) has seen a resurgence, largely driven by clinical benefit observed in patients treated with ADCs incorporating camptothecin-based topoisomerase I inhibitor payloads. Herein, we present development novel camptothecin ZD06519 (FD1), which been specifically designed for its application as an ADC payload. A panel analogs different substituents at C-7 and C-10 positions core was prepared tested <i>in...
<p>HPLC-HIC, LC-MS, HPLC-SEC, residual free drug analysis, and endotoxin levels of ADCs</p>
<p>Supplementary Figure S2 shows the chemical stability of FD1 (ZD06519)</p>