There have been some reports demonstrating the biogenic synthesis of silver nanoparticles (AgNPs) using Calotropis procera (CP) plant extract; however, detailed in-depth debriefing vital parameter for rapid, facile, efficacious at varied temperatures with effectual characterization and biomimetic attribute is lacking. This study presents a comprehensive demarcation sustainable fabrication C. flower extract capped stabilized (CP-AgNPs) thorough phytochemical potential biological application....

The aim of the present study is to develop Doxorubicin-Erlotinib nanoparticles (Dox-Erlo NPs) and folate-armored Dox-Erlo-NP conjugates for targeting glioma cancer. Glioma one most common progressive cancerous growths originating from brain glial cells. However, blood-brain barrier (BBB) only semi-permeable highly selective as which compounds are let through; designing that overcome this constraint therefore a major challenge in development pharmaceutical agents. We demonstrate NP studied...

Glioma is a malignant form of brain cancer that challenging to treat due the progressive growth glial cells. To target overexpressed folate receptors in glioma tumors, we designed and investigated doxorubicin-gefitinib nanoparticles (Dox-Gefit NPs) conjugated Dox-Gefit NPs NPs-F). NPs-F were characterized by multiple techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), proton nuclear magnetic resonance (1H...

Interventions by the pharmacists have always been considered as a valuable input health care community in patient process reducing medication errors, rationalizing therapy and cost of therapy. The primary objective this study was to determine number types errors intervened dispensing at OPD pharmacy Khoula Hospital during 2009 retrospectively. interventions filed assistant were collected. Then they categorized analyzed after detailed review. results show that 72.3% minor which 40.5% about...

Diabetes mellitus (DM) is a prevalent metabolic disorder attributed to insulin secretion and action defects, affecting growing adult population with hyperglycemia expected reach 578 million by 2030. This study explores the antidiabetic potential of 25% aqueous methanol extract Cupressus torulosa needles, utilizing in vitro vivo assays. In α-glucosidase inhibition assay, exhibited significant activity an IC50, 123.45 ± 1.8 μg/mL, comparable standard drug acarbose (IC50, 58.21 3.1 μg/mL)....

There are many high-altitude plants such as Skimmia anquetilia that unexplored for their possible medicinal values. The present study was conducted to examine the antioxidant activities of (SA) using in vitro and vivo models. SA hydro-alcoholic extracts were investigated LC-MS chemical constituents. essential oil evaluated pharmacological properties. properties DPPH, reducing power, cupric metal chelating assays. anti-hemolytic activity carried out a human blood sample. CCL4-induced...

Nanoemulgel (NEG) pharmaceutical formulations are gaining popularity because of their ability to serve both as a nanoemulsion and gel. These products well-known for ease use, spreadability, controlled release, hydrate dry skin. Natural essential oils have been shown promote the cutaneous permeability topical formulations, enhancing medication safety efficacy. Herein, we developed NEG enhanced permeation ketoconazole against candidiasis using clove oil (clove-oil-NEG) or eucalyptus...

The roots of Calotropis gigantea have been used in leprosy, eczema, syphilis, elephantiasis, ulceration and cough the Indian system traditional medicine. present communication evaluated its antipyretic activity by using yeast-induced TAB (Typhoid) vaccine-induced pyrexia rats rabbits. In both fever, fever was significantly reduced body temperature normalized administration 200 400 mg/kg dose intraperitoneally. Based on results study it can be concluded that extract C. has potential against...

To evaluate the hypoglycemic and anti-diabetic activity of chloroform extract Calotropis gigantea leaves flowers in normal rats streptozotocin induced diabetes.The was carried out by treatment using leaf flower 10, 20 50 mg/kg, orally. The oral glucose tolerance test administering (2 g/kg, p.o), to non-diabetic treated with extracts at doses p.o glibenclamide 10 mg/kg. serum then measured 0, 1.5, 3 5 hr after administration extracts/drug. Streptozotocin-induced diabetic were administered...

Background: The plant Tinospora cordifolia (TC), traditionally known as guduchi or giloy, is used for a number of health conditions nutritional supplement and rejuvenation medicine. Its supplementary products are recommended wide range issues, including diabetes, menstruation discomfort, fever, obesity, inflammation, more. Unfortunately, there has not been extensive research into its effectiveness in treating managing insulin resistance, lipid carbohydrate metabolism, hormonal imbalance,...

The plain 5-fluorouracil (5FU) formulations available in the market are associated with adverse effects such as skin irritation, pruritus, redness, blisters, allergy, and dryness on site of application. objective present study was to develop a liposomal emulgel 5FU increased permeability efficacy using clove oil eucalyptus along pharmaceutically acceptable carriers, excipients, stabilizers, binders, additives. A series seven were developed evaluated for their entrapment efficiency, vitro...

<b>Objectives:</b> The antioxidant potential of gossypin and nevadensin, two flavonoid compounds, were evaluated by <i>in vitro</i> methods.<br><b> Materials Methods:</b> Gossypin, the reference standard, butylated hydroxyl toluene (BHT), for DPPH (1, 1-diphenyl-2-picrylhydrazyl), nitric oxide, superoxide, radical scavenging activity.<br><b> Results:</b> Gossypin BHT showed significant inhibition up to 88.52 91.45% at 100 µg/ml concentration. With a concentration gossypin, activity was found...

The Aristolochia bracteata is well known for its antiarthritis properties in Indian system of medicine and folk medicine. objective the present study was to evaluate claim rheumatoid arthritis (RA) propose a probable mechanism action. Anti arthritic activity evaluated using Freund's complete adjuvant rats, course treatment followed over 4 weeks post inoculation period health parameters, clinical behavioral methods study. Estimation blood Hb, ESR change body weight were considered as...

Graphene quantum dots (GQDs) are prepared and characterized via X-ray diffraction (XRD), UV-Visible spectroscopy, atomic force microscopy (AFM), transmission electron (TEM) photoluminescence (PL). GQDs doped (5 mg 10 mg) in the lyotropic liquid crystalline (LLC) lamellar hexagonal phases to prepare GQD/LLC nanocolloids. Polarizing optical measurement reveals that do not affect LLC structures may organize on their interface. Pure nanocolloids studied for steady dynamic rheological behavior....

Physical and psychological stress has an inverse relation with male libido sperm quality. The present study investigates the potential fertility-enhancing properties of Desmodium gangeticum (DG) root extracts in Wister rats subjected to immobilization-induced (SIMB). DG roots were extracted using n-hexane (HEDG), chloroform (CEDG), water (AEDG). In pilot study, aphrodisiac protentional was investigated at two doses (125 250 mg kg−1) each extract. main HEDG AEDG 125 kg−1 challenged for by...

Swarnabhasma, an Ayurvedic preparation containing Calotropis gigantea R. Br. (Asclepiadaceae) is extensively used by physicians for treatment of diabetes mellitus, bronchial asthma, rheumatoid arthritis and nervous disorders. In the present study, we report effect chloroform extracts leaf flower on free radical scavenging activity, lipid profile in streptozotozin-induced diabetic rats. The peroxidation, superoxide dismutase, catalase were measured liver homogenate serum glutamic pyruvic...

Osteoporosis is a metabolic bone disease, characterized by increased porosity of the skeleton resulting from reduced mass, associated structural changes predispose to fracture.The drug discovery process in this direction very attractive, because non-availability suitable, safe and effective means for management condition.The objective study was evaluate antiosteoporotic activity Asparagus racemosus.Ovariectomized rats model used evaluation.Effects were evaluated using biomechanical, mineral,...