A5083288777- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Cardiovascular and Diving-Related Complications
- Neuroscience of respiration and sleep
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Physical Activity and Health
- Cardiovascular Effects of Exercise
- Neutropenia and Cancer Infections
- Neonatal Respiratory Health Research
- Chronic Disease Management Strategies
- Context-Aware Activity Recognition Systems
- Allergic Rhinitis and Sensitization
- Tuberculosis Research and Epidemiology
- Biomarkers in Disease Mechanisms
- Hematological disorders and diagnostics
- Sepsis Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Tracheal and airway disorders
- Immune Response and Inflammation
St Olav's University Hospital
2016-2025
Norwegian University of Science and Technology
2016-2025
Oslo University Hospital
2021
University of Oslo
2021
National University of Singapore
2021
Lovisenberg Diakonale Sykehus
2021
Leipzig Heart Institute
2016
Leipzig University
2016
Committee on Publication Ethics
2016
University of California, San Diego
2009
Abstract Objective To evaluate the effect of five years supervised exercise training compared with recommendations for physical activity on mortality in older adults (70-77 years). Design Randomised controlled trial. Setting General population Trondheim, Norway. Participants 1567 6966 individuals born between 1936 and 1942. Intervention were randomised to two sessions weekly high intensity interval at about 90% peak heart rate (HIIT, n=400), moderate continuous 70% (MICT, n=387), or follow...
Rationale: Sleep apnea (SA) is highly prevalent in patients with atrial fibrillation (AF), and both conditions are associated adverse cardiovascular outcomes.Objectives: To determine the effect of continuous positive airway pressure (CPAP) on AF burden.Methods: This open-label, parallel-group, randomized controlled trial included paroxysmal moderate to severe SA (apnea-hypopnea index ⩾15). A computerized system eligible (1:1) 5 months' treatment CPAP plus usual care (CPAP, n = 55) or alone...
Obstructive sleep apnea (OSA) is associated with atrial fibrillation (AF). Whether treatment continuous positive airway pressure (CPAP) reduces AF recurrence after catheter ablation pulmonary vein isolation (PVI) unknown.The purpose of this study was to assess the effect CPAP on and burden PVI in patients OSA.We randomized paroxysmal an apnea-hypopnea index (AHI) ≥15 events/hour or standard care. Heart rhythm monitored by implantable loop recorder. defined as any episode lasting >2 minutes a...
Purpose: A diminished mechanical efficiency (work/O2 consumed) accompanies chronic obstructive pulmonary disease (COPD), and increased has been attained by maximal strength training (MST) with an emphasis on the rate of force mobilization in concentric phase healthy subjects. This study combined these observations evaluated impact short-term MST patients COPD. Methods: Twelve COPD (FEV1 = 1.1 ± 0.1) were pretested then randomly assigned to either group (N 6) or a normal activity control 6)....
Recent studies have suggested an association between sleep apnea (SA) and atrial fibrillation (AF). We aimed to study the prevalence, characteristics, risk factors type of in ablation candidates with paroxysmal AF.We prospectively studied 579 patients AF, including 157 women (27.1%) 422 men (72.9%). Mean age was 59.9 ± 9.6 years mean body mass index (BMI) 28.5 4.5 kg/m2. SA diagnosed using polygraphy for two nights at home. The Epworth Sleepiness Scale (ESS), STOP-Bang Questionnaire, Berlin...
We administered a neutralizing monoclonal antibody to tumor necrosis factor (TNF) during infection with Candida albicans in normal and granulocytopenic mice. Mice were rendered (less than 0.1 x 10(9) granulocytes per liter) cyclophosphamide. Growth of C. from the kidneys was significantly increased mice treated TNF, compared that control mice, after 36 h (3.6 10(4) +/- 1.2 CFU kidney versus 9.1 10(3) 6.2 kidney; P less 0.05) 72 (3.7 10(6) 2.7 2.3 1.3 0.01). In TNF had no effect on growth...
Purpose To provide a large reference material on key cardio-respiratory variables in healthy population of Norwegian men and women aged 20–90 years. Methods Sub maximal peak levels were measured using cardiopulmonary exercise testing during treadmill running. Results The highest ventilation among (141.9±24.5 L·min−1) (92.0±16.5 was observed the youngest age group (20–29 years, sex differences p<0.001) with an average 7% reduction per decade. tidal volumes 30–39 40–49 year groups (2.94±0.46...
Introduction Epidemiological studies suggest that exercise has a tremendous preventative effect on morbidity and premature death, but these findings need to be confirmed by randomised trials. Generation 100 is randomised, controlled study where the primary aim evaluate effects of 5 years training mortality in an elderly population. Methods analysis All men women born 1936–1942 (n=6966), who were residents Trondheim, Norway, invited participate. Between August 2012 June 2013, total 1567...
Improving reduced skeletal muscle function is important for optimising exercise tolerance and quality of life in chronic obstructive pulmonary disease (COPD) patients. By applying high-intensity training to a small group, we hypothesised normalisation function. Seven patients with COPD performed 6 weeks (3 days·week −1 ) interval aerobic knee extensor training. Five age-matched healthy individuals served as reference group. Muscle oxygen uptake mitochondrial respiration the vastus lateralis...
Purpose The training response of an intensified period high-intensity exercise is not clear. Therefore, we compared the cardiovascular adaptations completing 24 aerobic interval sessions carried out for either three or eight weeks, respectively. Methods Twenty-one healthy subjects (23.0±2.1 years, 10 females) completed throughout a time-period weeks (moderate frequency, MF) (high HF) followed by detraining nine without any training. In both groups, maximal oxygen uptake (VO2max) was...
Abstract Aims The aim of this study was to compare the effects 5 years supervised exercise training (ExComb), and differential subgroups high-intensity interval (HIIT) moderate-intensity continuous (MICT), with control on cardiovascular risk profile in older adults. Methods results Older adults aged 70–77 from Trondheim, Norway (n = 1567, 50% women), able safely perform were randomized two weekly sessions HIIT [∼90% peak heart rate (HR), n 400] or MICT (∼70% HR, 387), together forming ExComb...
Background : Interventions promoting increased physical activity (PA) and limited sedentary time in older adults are urgently required. This study examines how 5 years of supervised high-intensity interval training (HIIT), or moderate-intensity continuous (MICT) affects PA measured objectively, during, after the intervention, compared to an unsupervised control group. Methods In total, 1405 participants with a mean age 72.8 years, consisting 51% females, were randomized 1:1:2 2 weekly...
Abstract TNF mediates multiple biologic activities through two distinct cell surface receptors, TNFR-p55 and TNFR-p75. plays an important role in nonspecific resistance against the fungus Candida albicans. We used transgenic mice deficient for or TNFR-p75 to investigate of TNFR antifungal defense. Mice have highly impaired ability clear infection with C. albicans readily succumb infection. Also had a significant reduction their although lethality was not increased. These data demonstrate...
Background Fluticasone furoate/vilanterol (FF/VI) is a novel once-daily (OD) inhaled corticosteroid/long-acting β(2) agonist combination in development for chronic obstructive pulmonary disease (COPD) and asthma. Trial design A multicentre, randomised, double-blind, parallel-group, placebo-controlled study. Methods Participants were patients with moderate-to-severe COPD treated placebo or FF/VI 400/25 μg OD 4 weeks. Study objectives to assess the safety efficacy of administered weeks via dry...
Purpose Cardiorespiratory fitness (CRF) is regarded a clinical vital sign, and accurate reference values for all age groups are essential. Little data exist on CRF cardiorespiratory function in older adults. The aim of this study was to provide normative adults, including people with history cardiovascular diseases (CVD). Methods In total, 1537 (769 women) participants 70 77 yr underwent examinations cardiopulmonary exercise tests. Peak oxygen uptake (V˙O2peak), ventilation (V˙Epeak),...
Objective: The aim of this study was to investigate the effects moderate continuous training (MCT) and high intensity aerobic interval (AIT) on systolic ventricular function capacity in COPD patients. Methods: Seventeen patients with (64 ± 8 years, 12 men) FEV1 52.8 11% predicted, were randomly assigned isocaloric programs MCT at 70% max heart rate (HR) for 47 minutes) or AIT (∼90% HR 4×4 three times per week 10 weeks. Baseline cardiac compared 17 age- sex-matched healthy individuals. Peak...
Chronic obstructive pulmonary disease (COPD) is one of the main causes morbidity and mortality globally. In Trondheim in 2008 an integrated care model (COPD-Home) consisting education program, self-management plan, home visits a call centre for patient support communication was developed. The objective to determine efficacy intervention according COPD-Home reducing hospital utilization among patients with COPD stage III IV (GOLD 2007) discharged after hospitalization acute exacerbations...
Although reduced function of the respiratory system limits peak oxygen uptake in diseases affecting lungs or airways, healthy is thought to have a spare capacity for transport and uptake, not considered limiting factor people. However, lung declines with age could theoretically limit elderly. We examined association between indices an elderly population hypothesis that would be associated VO2peak up threshold value situated above lower normal our population. Spirometry, gas diffusion tests...
Background Implementation of the COPD-Home integrated disease management (IDM) intervention at discharge after hospitalizations for acute exacerbations COPD (AECOPD) led to reduced hospital utilization during following 24 months compared year prior study start. Aims To analyze impact IDM on health related quality life, symptoms anxiety and depression, degree patient activation follow-up assess association between these outcomes. Methods A single center, prospective, open, controlled clinical...
Lower respiratory tract infection is the most common cause of acute exacerbations chronic obstructive pulmonary disease (AECOPD). The aim present study was to compare accuracy procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC) as single diagnostic tests in combination with clinical signs symptoms diagnose pneumonia patients hospitalized AECOPD. This a prospective, centre observational study. Patients spirometry-confirmed COPD who were due AECOPD consecutively...
Cigarette smoking is the main risk factor for chronic obstructive pulmonary disease and emphysema. However, evidence on extrapulmonary effects of smoke exposure that precede lung impairments remains unclear at present, as are data nonpharmacological treatments such exercise training.Three groups mice, including control (n = 10), with 6 wk high-intensity interval treadmill running 11), were exposed to 20 fresh air or whole-body cigarette smoke. Exercise capacity (peak oxygen uptake)...