A5006084937- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Chemistry and Chromatography
- Biochemical Acid Research Studies
- Electrochemical sensors and biosensors
- biodegradable polymer synthesis and properties
- Biofuel production and bioconversion
- Catalysis for Biomass Conversion
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Amino Acid Enzymes and Metabolism
- Biochemical and biochemical processes
- Enzyme Production and Characterization
- Glycosylation and Glycoproteins Research
- Ionic liquids properties and applications
- Metalloenzymes and iron-sulfur proteins
- Protein purification and stability
- Fluid Dynamics and Mixing
- Steroid Chemistry and Biochemistry
- Asymmetric Hydrogenation and Catalysis
- Mesoporous Materials and Catalysis
- Enzyme-mediated dye degradation
- Chemical Synthesis and Reactions
- Chemistry and Chemical Engineering
United Nations University
2025
Universität Hamburg
2016-2025
Hamburg University of Technology
2016-2025
Society for Chemical Engineering and Biotechnology
2020
Institute of Catalysis and Petrochemistry
2016-2020
Biocat
2016-2020
Keio University
2018
The University of Adelaide
2014
Laboratoire de Chimie Moléculaire et Thioorganique
2012
Mettler-Toledo (United States)
2010
Abstract Poly‐ε‐caprolactone (PCL) is chemically produced on an industrial scale in spite of the need for hazardous peracetic acid as oxidation reagent. Although Baeyer–Villiger monooxygenases (BVMO) principle enable enzymatic synthesis ε‐caprolactone (ε‐CL) directly from cyclohexanone with molecular oxygen, current systems suffer low productivity and are subject to substrate product inhibition. The major limitations such a biocatalytic route produce this bulk chemical were overcome by...
The increasing awareness of man-made environmental impact our modern highly industrialized societies has led to an demand natural products representing additionally a key element within the transition towards circular bioeconomy. In this sense, macroalgae constitute renewable and abundant resource with high usage potentials in wide range very diverse applications. addition respective useable bioactive compounds varying between species more significantly three taxonomic groups, are...
The thiamin diphosphate- and Mg2+-dependent enzyme benzoylformate decarboxylase (BFD) from Pseudomonas putida was characterized with respect to its suitability catalyze the formation of chiral 2-hydroxy ketones in a benzoin-condensation type reaction. Carboligation constitutes side reaction BFD, whereas predominant physiological task is non-oxidative decarboxylation benzoylformate. For this purpose obtained sufficient purity cells one-step purification using anion-exchange chromatography. To...
Industrial biocatalysis is older than one might think. In the past, entire microorganisms have been used, for instance, production of acetic acid from ethanol. The racemic resolution amino acids via acylase method regarded as first industrial processes using isolated enzymes (Tanabe, Japan, 1969). Presently, approximately 100 different biotransformations are carried out in industry, mostly pharmaceutical and agrochemical precursors. most cases, chiral compounds (fine chemicals) obtained....
Due to favourable partition coefficients the highly enantioselective reduction of 2-octanone, catalysed by an alcohol dehydrogenase from Lactobacillus brevis, is faster in a biphasic system containing buffer and ionic liquid [BMIM][(CF(3)SO(2))(2)N] compared methyl tert-butyl ether.
It depends on the choice. The conciliation of high chemo- and enantioselectivity alcohol dehydrogenase(ADH)-catalyzed reduction ketones poor water solubility substrates can be achieved in aqueous–organic biphasic systems (see picture). But how should organic phase chosen? Supporting information for this article is available WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51089_s.pdf or from author. Please note: publisher not responsible content functionality any supporting supplied...
To overcome limitations due to the high viscosity in solvent free esterification of polyglycerol-3 and related polyols, such as poly(ethylene glycol)s, an alternative reactor concept was developed. The new comprises a bubble column that prevents mechanical erosion Novozym 435 (lipase B from Candida antarctica) found by stirring mixture. That way laurate synthesized at space time yield (sty) 3042 g/L/d PEG-55-propylene glycol dioleate sty 738 g/L/d. proof broad application range this system,...
Triacylglycerol lipases (EC 3.1.1.3) catalyze both hydrolysis and synthesis reactions with a broad spectrum of substrates rendering them especially suitable for many biotechnological applications. Most used today originate from mesophilic organisms are susceptible to thermal denaturation whereas only few possess high thermotolerance. Here, we report on the identification characterization two novel thermostable bacterial identified by functional metagenomic screenings. Metagenomic libraries...
This review highlights the state of art in field coupled chemo(enzymatic) reactions continuous flow. Three different approaches to such reaction systems are presented herein and discussed view their advantages disadvantages as well trends for future development.
Enzymatic synthesis of sugar fatty acid esters in organic solvents is a well‐described procedure to synthesize glycolipids. This study aims at replacing these with deep eutectic (DES), group that gained more and interest during the last years, since they can be easily produced from non‐toxic resources. glycolipid was investigated, employing Candida antarctica lipase B (Novozyme 435) various solvents. A successful lipase‐catalyzed glucose gave proof this concept, while using two consisting...
Bacterial cell-cell communication (quorum sensing, QS) represents a fundamental process crucial for biofilm formation, pathogenicity, and virulence allowing coordinated, concerted actions of bacteria depending on their cell density. With the widespread appearance antibiotic-resistance biofilms, there is an increasing need novel strategies to control harmful biofilms. One attractive most likely effective approach target bacterial systems drug design in biotechnological medical applications....
Abstract Biorefineries are a model for greener production processes, based on the concept of bioeconomy. Instead targeting first-generation biofuels—that compete with food supply—the focus relies lignocellulosic material, considering many aspects, such as sustainable fuel production, well valorization waste, an alternative to traditional petrochemical approach goods production. Especially, in tropical countries agricultural activities lead tremendous amounts biomass, resulting waste that has...
The optimization of the pharmacokinetic performance various 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors following oral administration to either beagle dogs or CM-monkeys is described. molecules described in this work are composed a peptidomimetic binding determinant and an alpha,beta-unsaturated ester Michael acceptor moiety which forms irreversible covalent adduct with active site cysteine residue enzyme. Modification contained within these compounds detailed...