A5030907060- Cyclopropane Reaction Mechanisms
- Axial and Atropisomeric Chirality Synthesis
- Catalytic Alkyne Reactions
- Boron Compounds in Chemistry
- Molecular spectroscopy and chirality
- Chemical Synthesis and Analysis
- Organoboron and organosilicon chemistry
- Oxidative Organic Chemistry Reactions
- Nonlinear Waves and Solitons
- Asymmetric Hydrogenation and Catalysis
- Chemical synthesis and alkaloids
- Catalytic C–H Functionalization Methods
- Cyclization and Aryne Chemistry
- Synthetic Organic Chemistry Methods
Colorado State University
2024
Indian Institute of Science Bangalore
2021-2023
Although the atroposelective synthesis of biaryls and related compounds bearing axially chiral C–C bonds is well-known, C–N bond-containing relatively less explored, construction N–N has received only scant attention. Demonstrated herein N-heterocyclic carbene (NHC)-catalyzed selective amidation reaction, leading to 3-amino quinazolinones. The NHC-catalyzed reaction quinazolinones containing a free N–H moiety with α,β-unsaturated aldehydes under oxidative conditions furnished atropisomeric...
A facile synthesis of biologically important S-aryl dithiocarbamates has been demonstrated by the aryne three-component coupling involving CS2 and aliphatic amines. This transition-metal-free mild reaction is scalable operates with good functional group compatibility. Preliminary mechanistic experiments, including density theory studies, are also provided. Moreover, 3-triflyloxybenzynes, a unique four-component incorporating tetrahydrofuran was observed.
We computationally study the mechanistic pathway for synthetically valuable cascading N-H functionalization followed by C-C bond-forming reaction. The impetus to such multicomponent reactions catalyzed Rh(I) arises from highly fluxional nature of onium ylide involved, which is often not amenable experimental detection. Our results throw light on an interesting paradigm where binding metal plays a crucial role. provides some much-needed insights expand scope these methodologies broader range...
Asymmetric diboration of terminal alkenes is well established, and subsequent selective functionalization the less hindered primary boronic ester commonly achieved. Conversely, sterically accessible secondary remains challenging. An alternative way to control chemoselective bis(boron) compounds by engendering different Lewis acidity two boryl moieties, since reactivity would then be dictated instead sterics. We report herein regio- enantioselective Pt-catalyzed unactivated with...
Abstract Asymmetric diboration of terminal alkenes is well established, and subsequent selective functionalization the less hindered primary boronic ester commonly achieved. Conversely, sterically accessible secondary remains challenging. An alternative way to control chemoselective bis(boron) compounds by engendering different Lewis acidity two boryl moieties, since reactivity would then be dictated instead sterics. We report herein regio‐ enantioselective Pt‐catalyzed unactivated with...
DFT methods are used to probe the mechanism of a newly developed Ir-quinoid catalyzed C(sp3)-H functionalization 1,4 dienes. The lowest energy pathway proceeds via an old-school concerted C-H insertion as opposed unique hydrogen atom transfer process proposed previously. concertedness reaction shows intriguing dependence on sterics diene leading either inserted or dehydrogenated products. We use these new insights tune axial ligand, and design more efficient catalyst.
Although the atroposelective synthesis of biaryls and related compounds bearing axially chiral C-C bonds are well-known, C-N bond-containing relatively less explored, construction N-N has received only scant attention. Demonstrated herein is N-heterocyclic carbene (NHC)-catalyzed selective amidation reaction leading to 3-amino quinazolinones. The NHC-catalyzed quinazolinones containing a free N-H moiety with -unsaturated aldehydes under oxidative conditions furnished atropisomeric...