A5001439184- Cardiac electrophysiology and arrhythmias
- Connexins and lens biology
- Cardiac Ischemia and Reperfusion
- Ion channel regulation and function
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Atrial Fibrillation Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrhythmias and Treatments
- Renal Transplantation Outcomes and Treatments
- Cardiac and Coronary Surgery Techniques
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Anesthesia and Neurotoxicity Research
- Cardiac Valve Diseases and Treatments
- Heat shock proteins research
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Mesenchymal stem cell research
- Cardiac Fibrosis and Remodeling
- Aortic Disease and Treatment Approaches
- Heart Rate Variability and Autonomic Control
Leipzig University
2014-2024
Leipzig Heart Institute
2010-2022
Klinikum Altenburger Land
2021-2022
DAK-Gesundheit (Germany)
2021
Deutsches Herzzentrum der Charité
2009-2019
Carl von Ossietzky Universität Oldenburg
2017
University of the Free State
2017
University of Geneva
2017
Semmelweis University
2017
Ghent University
2017
Cyclic mechanical stretch (CMS) is an important physiological and pathological factor in the heart.We examined whether CMS can affect localization of gap junctions with regard to cell axis.Neonatal rat cardiomyocytes were cultured (7 days) on flexible 6-well plates. Thereafter, cells kept static or stimulated (1 Hz; 0, 10, 20% elongation) for 24, 48 hours (with without 10 micromol/L PD98059, 5 BIM I (bisindolylmaleimide I), 2 H8 [N-(2-methlyamino-ethyl)-5-isoquinoline-sulfonamid], 0.1...
Endothelin-1 (ET-1) and angiotensin-II (AT-II) participate in the pathophysiology of cardiovascular diseases. Regulation gap junctional intercellular communication may influence heart function its response to cardiac injury. In this study, we examined effects ET-1 AT-II on connexin43 (Cx43) connexin40 (Cx40) cultured neonatal rat ventricular cardiomyocytes (NRCs) role mitogen-activated protein kinase signaling ET-1- AT-II-induced responses. NRCs were incubated for 24 h with either or (each...
<i>Objectives:</i> Garlic <i>(Allium sativum)</i> has a well-established reputation as protective agent against cardiovascular disease, while nearly nothing is known about its cousin <i>Allium ursinum</i>. The aim of this study was to evaluate the antiaggregatory mechanism garlic and compare effects <i>A. ursinum</i> sativum</i>. <i>Methods:</i> In prospective study, extracts were prepared from sativum</i> powder made...
Abstract Aims Although in persistent atrial fibrillation (AF) a complex AF substrate characterized by high incidence of conduction block has been reported, relatively little is known about complexity paroxysmal (pAF). Also, the relative contribution various aspects structural alterations to disturbances not clear. In particular, endomysial fibrosis during progression studied yet. Methods and results During cardiac surgery, epicardial high-density mapping was performed patients with acutely...
School-level infection control measures in Germany during the early Coronavirus Disease 2019 (COVID-19) pandemic differed across 16 federal states and lacked a dependable evidence base, with available limited to regional data restricted short phases of pandemic. This study aimed assess (a) risks students staff; (b) transmission routes schools; (c) effects school-level on school population dynamics; (d) contribution contacts schools cases.
Background —Recent evidence indicates that certain genotypes of β 2 -adrenoceptors (AR) may indicate an increased risk cardiovascular disease or rate progression. Of particular importance, the Thr164Ile polymorphism, which is found in ≈4% humans, shows decreased receptor signaling, blunted cardiac response when expressed transgenic mice, and associated with a survival patients congestive heart failure. Methods Results —In this study, we compared functional activity, ie, chronotropic (heart...