A5071442382- Essential Oils and Antimicrobial Activity
- Tannin, Tannase and Anticancer Activities
- Antioxidant Activity and Oxidative Stress
- Molecular Biology Techniques and Applications
- Ginger and Zingiberaceae research
- Cholinesterase and Neurodegenerative Diseases
- Vitamin C and Antioxidants Research
- Genomics, phytochemicals, and oxidative stress
- Nephrotoxicity and Medicinal Plants
- Hydrogen's biological and therapeutic effects
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Cancer, Lipids, and Metabolism
- Biochemical effects in animals
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects and Toxicity Studies
- Natural product bioactivities and synthesis
- Nutrition, Genetics, and Disease
- Pharmacology and Obesity Treatment
- Hibiscus Plant Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Alzheimer's disease research and treatments
- Cynara cardunculus studies
National Research Centre
2013-2024
Ginger is a remedy known to possess number of pharmacological properties. This study investigated efficacy ginger pretreatment in alleviating acetaminophen-induced acute hepatotoxicity rats. Rats were divided into six groups; negative control, acetaminophen (APAP) (600 mg/kg single intraperitoneal injection); vitamin E (75 mg/kg), (100 + APAP, and APAP. Administration APAP elicited significant liver injury that was manifested by remarkable increase plasma alanine aminotransferase (ALT),...
The potential of plant-based diets and drugs to prevent control obesity has been attributed the presence several biologically active phytochemicals. study aimed assess herb consumption's impact on alleviating risks hazards associated with induced by a high-fat diet (HFD) promotion fertility. Eighty rats were allocated into four distinct groups. Group 1 (G1) was provided basal acted as group. 2 (G2) an HFD. 3 (G3) HFD supplemented chia seeds Hibiscus sabdariffa L. fourth group subjects...
Diabetes mellitus (DM) and hypercholesterolemia (HC) when poorly controlled lead to debilitating central nervous system complications including cognitive deficits memory impairment. In the present study, we investigated mechanisms that may be responsible for such deficits.Both diabetes HC were induced in two groups of rats independently using alloxan high cholesterol diet, respectively.Acetyl cholinesterase was significantly increased brain diabetic rats. Also, malondialdehyde level...
Gentamicin (GM) is a drug used commonly against gram-negative bacteria. Its therapeutic use mainly limited by its nephrotoxicity. This investigation was aimed at evaluating the nephroprotective effects of rosemary (RM; Rosmarinus officinalis) and thyme (TV; Thymus vulgaris) GM toxicity. Rats were divided into four groups. Normal control group treated intraperitoneally (i.p.) with saline; positive administered 60 mg/kg/day i.p.; RM co-administered 8% aqueous extract, 10 mL/kg/day, orally GM;...
Water from holy zamzam is consumed by many Muslims in the world due to its beneficial role for health of human beings.Therefore present study was designed evaluate effect water diabetes mellitus, nephrotoxicity and hepatotoxicity rats as well determine chemical analysis this water. Fifty six male albino weighting (150±5gm) were divided into four main groups each group two subgroups a b, one administered tap (Tw) other subgroup (zw). The 1st normal rat (-ve control), 2nd diabetic (induced...
The present study aimed to evaluate the chemopreventive potential of Pinus roxburghii branch (P. roxburghii) and Nauplius graveolens (N. graveolens) extracts against human colorectal cancer (CRC) induced by C26 murine cells in a BALB/c mouse model. Real-time qRT-PCR was used apoptotic pathway measuring relative mRNA expression levels Bcl-2, Bax, Cas3, NF-κB, PI3k genes. At termination 30-day period, blood samples were collected assay biomarkers. results showed significant increase (p <...
The use of phytochemicals is gaining increasing attention for treating cancer morbidity with minimal burden side effects. This study evaluated the cytotoxicity and antimicrobial activities Pinus roxburghii branch (P. roxburghii) Nauplius graveolens (N. graveolens) extracts in vitro. Cell viability was estimated using MTT assay. DNA fragmentation determined to detect apoptotic pathway initiation. Mechanistically, tracked by estimating relative mRNA expression levels Bcl-2, Bax, Cas3, NF-κB,...
The objective of this study was to evaluate the potential toxicity methanolic extracts Pinus roxburghii branch (P.roxburghii) and Nauplius graveolens (N.graveolens).Single oral dosage administered male mice at increasing concentrations 100, 250,500,1000 2000 mg/kg body weight assess median LD50, which causes death 50% (one half) mice.Blood samples were collected end 14 days toxicological trial for liver kidney function tests.The results showed that LD50 P. 1708.3 mg/ kg N. 1562.5 weight.The...
Background: Nano micronutrients and their relationship to health or disease is one of the domains modern needs many extensive researches studies. Aim: This work was carried out study effect some nano nutrients induce apoptosis in breast cancer inhibitory them on development toxic material mammary tumor for 180 days against injected intraperitoneally a single dose (50 mg/kg) N-methyl-N-nitrosourea (MNU) female rats. Experimental animals this divided into two categories, first category:...