A5053860533- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Genetic factors in colorectal cancer
- Plant Virus Research Studies
- Primate Behavior and Ecology
- T-cell and B-cell Immunology
- Cancer, Hypoxia, and Metabolism
- vaccines and immunoinformatics approaches
- Animal Behavior and Welfare Studies
- Virus-based gene therapy research
- Ferroptosis and cancer prognosis
- COVID-19 epidemiological studies
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Bacillus and Francisella bacterial research
- RNA modifications and cancer
- Animal Behavior and Reproduction
Nouscom (Italy)
2024-2025
Agostino Gemelli University Polyclinic
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Fondazione Santa Lucia
2021-2023
Génomique Bioinformatique et Applications
2023
Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana
2017
National Institute of Infectious Diseases
2017
The emergence of the highly contagious Omicron variant SARS-CoV-2 and findings a significantly reduced neutralizing potency sera from individuals with previous infection or vaccination highlights importance studying cellular immunity to estimate degree immune protection new variant.To determine T-cell reactivity in established (natural and/or vaccine-induced) SARS-CoV-2.This was cohort study conducted between December 20 21, 2021, at Santa Lucia Foundation Istituto di Ricovero e Cura...
In January 2015, during a 3-week period, 12 captive Tonkean macacques at sanctuary in Italy died. An orthopoxvirus infection was suspected because of negative-staining electron microscopy results. The diagnosis confirmed by histology, virus isolation, and molecular analysis performed on different organs from all animals. epidemiologic investigation unable to define the source surrounding area. Trapped rodents were negative virologic testing, but specific IgG detected 27.27% small 14.28%...
Abstract Cancer interception represents a new approach, aimed at targeting precancerous lesions and therefore preventing cancer occurrence. Lynch syndrome (LS) is one of the most prevalent hereditary syndromes, with an estimated prevalence in 300, high-risk predisposition to several types cancer, up 80% lifetime risk develop CRC. LS caused by germline mutations DNA mismatch repair (MMR) genes. Loss MMR proteins causes accumulation microsatellite sequences, known as Microsatellite instability...
Orthopoxviruses (OPVs) are diffused over the complete Eurasian continent, but previously described strains mostly from northern Europe, and few infections have been reported Italy. Here we present extended genomic characterization of OPV Abatino, a novel isolated in Italy an infected Tonkean macaque, with zoonotic potential. Phylogenetic analysis based on 102 conserved genes (core gene set) showed that Abatino is most closely related to Ectromelia virus species (ECTV), although placed...
Abstract Importance The emergence of the highly contagious Omicron variant SARS-CoV-2 and findings a significantly reduced neutralizing potency sera from convalescent or vaccinated individuals imposes study cellular immunity to predict degree immune protection yet again new coronavirus. Design Prospective monocentric observational study. Setting Conducted between December 20-21 at Santa Lucia Foundation IRCCS. Participants 61 volunteers (Mean age 41.62, range 21-62; 38F/23M) with different...
We have reanalyzed the genomic data of International Collaboration for Genomics HIV (ICGH), centering on HIV-1 Elite Controllers.
Breakthrough infections in SARS-CoV-2 vaccinated individuals are an ideal circumstance for the simultaneous exploration of both vaccine-induced memory reaction to spike (S) protein and primary response membrane (M) nucleocapsid (N) proteins generated by natural infection. We monitored 15 healthcare workers who had been with two doses Pfizer BioNTech BNT162b2 were then later infected B.1.617.2. (Delta) variant, analysing antiviral humoral cellular immune responses. Natural infection...
Abstract Introduction: Brain metastases (BM) from Epithelial ovarian cancer (EOC) are a rare and late-stage disease manifestation, very poorly biologically characterized. We performed multi-omics characterisation of primary EOC samples (PT) the matched BM, to assess differences in mutational gene expression profiles. Material Methods: retrospectively collected data patients treated at Fondazione Policlinico Gemelli IRCCS who underwent surgical removal BM between 2011 2022. formalin-fixed,...
Abstract Lynch Syndrome (LS) is the most common hereditary cancer syndrome, caused by germline mutations in one of four DNA mismatch repair (MMR) genes. LS patients have a high risk to develop microsatellite instable (MSI) colorectal cancers. Tumors developed carriers display levels instability, which leads accumulation large numbers mutations, among frameshift insertion/deletions (indels) within (MS) loci are very and shared different tumors. When indels occur coding genes they give rise...
Abstract Lynch Syndrome (LS) is the most common hereditary cancer syndrome, caused by germline mutations in one of four DNA mismatch repair (MMR) genes. LS patients have a high risk to develop microsatellite instable (MSI) colorectal cancers. Tumors developed carriers display levels instability, which leads accumulation large numbers mutations, among frameshift insertion/deletions (indels) within (MS) loci are very and shared different tumors. When indels occur coding genes they give rise...