A5064818275- Reproductive tract infections research
- Bacterial Infections and Vaccines
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Blood groups and transfusion
- Reproductive System and Pregnancy
- Psidium guajava Extracts and Applications
- Ethnobotanical and Medicinal Plants Studies
- Antibiotic Resistance in Bacteria
- Cocoa and Sweet Potato Agronomy
- Pharmaceutical and Antibiotic Environmental Impacts
- Escherichia coli research studies
- Vector-borne infectious diseases
- Click Chemistry and Applications
- Alkaloids: synthesis and pharmacology
- Streptococcal Infections and Treatments
- Syphilis Diagnosis and Treatment
- Plant Pathogenic Bacteria Studies
- Synthesis and Biological Evaluation
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Traditional and Medicinal Uses of Annonaceae
- Phenothiazines and Benzothiazines Synthesis and Activities
Mahidol University
2009-2019
8-Hydroxyquinoline (8HQ) compounds have been reported to possess diverse bioactivities. In recent years, drug repositioning has gained considerable attention in discovery and development. Herein, 8HQ (1) its derivatives (2-9) bearing various substituents (amino, nitro, cyano halogen) were investigated for their antimicrobial against 27 microorganisms (agar dilution method) antioxidant (DPPH activities. The parent exerted a highly potent activity Gram-positive bacteria including diploid fungi...
The multidrug resistance of Neisseria gonorrhoeae becomes a public health problem worldwide, especially the strain H041 that showed decrease susceptibility to ceftriaxone which is last resort for gonorrhea treatment. Therefore, simultaneous discovery and development new compound fight this pathogen urgently required. In study, 8-hydroxyquinoline (8HQ) derivatives were evaluated their antimicrobial activities against gonococcal using spectinomycin as reference drug. results 8HQ gave an...
Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes destroy antimicrobial drugs is one well-known mechanisms underlying resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported exert diverse biological effects such as antimicrobial, antioxidant antineurodegenerative activities. Herein, 8HQ (1), nitroxoline (NQ, 2) 7-Br-8HQ (3) investigated for activity against Enterobacteriaceae including extended spectrum β-lactamase...
Targeted metabolomics reveals the therapeutic impact of Eclipta prostrata on diet-induced non-alcoholic fatty liver disease in ratsAzza S. Helmy, Naglaa M. Sherif, Hassan Z. Ghanem, Nabaweya A. Ibrahim, Abdel Nasser G. El Gendy, Noha Hussein, Abdel-Hamid
Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) infection has been considered to be one of global health problems due limited classes effective antimicrobial drugs. Herein, 8‐hydroxyquinoline (8HQ) and its derivatives ( 1‐7 ) were investigated for their anti‐MRSA antioxidant activities. Cloxyquin 2 ), a halogenated 8HQ, exerted the highest activity (MIC 50 ≤ 5.57 μM) with high safety index, whereas an amino‐derivative 7 showed strongest activity. Additionally, quantitative...
Multiplex PCR was applied to explore the antimicrobial-resistance profiles of 145 gonococci isolated from Bangrak Hospital, Thailand in 2007. All isolates were clearly identified for plasmid-mediated resistant types penicillin (Asia, Africa and Toronto) tetracycline (American Dutch). This method can also predict decreased susceptibility ciprofloxacin by detection Ser-91 mutation. Prevalence rates penicillinase-producing Neisseria gonorrhoeae (PPNG) high-level tetracycline-resistance N....
Abstract The development of antimicrobial resistance Neisseria gonorrhoeae arising from wide dissemination resistant clones is a major global health problem. In this study, total 235 isolates N. isolated patients Bangrak Hospital were tested for their antibiotic susceptibilities to penicillin, norfloxacin, ofloxacin, ciprofloxacin, spectinomycin, and ceftriaxone. Mutation (Ser‐91) in the quinolone determining regions gyrA random amplification polymorphic DNA polymerase chain reaction...
Evaluation of the hepatoprotective effect methanol extract root Uvaria afzelii (Annonaceae)OFEIMUN Josephine Omose, EZE Gerald Ikechi, OKIRIKA Ogochukwu Marvin,UANSEOJE Sylvester O.