A5041669704- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Iron Metabolism and Disorders
- Systemic Lupus Erythematosus Research
- Hemoglobinopathies and Related Disorders
- Child Nutrition and Water Access
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
Hôpital Saint-Vincent-de-Paul
2013-2014
Institut Cochin
2013-2014
Inserm
2013-2014
Institut Gustave Roussy
2014
Institut Pasteur
2012
We have generated a panel of transgenic mice expressing HLA-A*01:03, -A*24:02, -B*08:01, -B*27:05, -B*35:01, -B*44:02, or -C*07:01 as chimeric monochain molecules (i.e., appropriate HLA α1α2 H chain domains fused with mouse α3 domain and covalently linked to human β2-microglobulin). Whereas surface expression several transgenes was markedly reduced in recipient that coexpressed endogenous H-2 class I molecules, substantial all observed lacking molecules. In these transgenic/H-2 null mice, we...
HFE , an MHC class Ib molecule that controls iron metabolism, can be directly targeted by cytotoxic TCR αβ T lymphocytes. Transgenic DBA /2 mice expressing, in a Rag 2 KO context, recognizes mouse (m ) were created to further explore the interface of with immune system. ‐transgenic m Hfe WT deleted ‐reactive cells thymus, but fraction reprogrammed able escape deletion. In contrast, deprived molecules mice) or expressing C 282→ Y mutated – most frequent mutation associated human hereditary...