A5008884590- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Boron Compounds in Chemistry
- Crystallography and molecular interactions
- Radioactive element chemistry and processing
- Fluorine in Organic Chemistry
- Synthesis and Catalytic Reactions
- Enzyme function and inhibition
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Chemical Reactions and Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Organoboron and organosilicon chemistry
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Organic Chemistry Cycloaddition Reactions
- Pharmacological Effects and Toxicity Studies
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Chemical Reactions and Isotopes
- Synthesis and Biological Evaluation
- Free Radicals and Antioxidants
St Petersburg University
2015-2023
University of Glasgow
2022
Three types of oxime species, i.e., 4-morpholylcarbamidoxime (hydroxyguanidine), phenylacetamidoxime and benzamidoxime (amidoximes), cyclohexanone benzophenone (ketoximes), react at room temperature with the 2-nitrilium closo-decaborate clusters, leading to 2-iminium closo-decaborates (14 examples; 57–94%). These species were characterized by ICPMS-based boron elemental analysis, HRESI–-MS, molar conductivity, IR, 1H{11B}, 11B{1H} NMR spectroscopies, additionally single-crystal X-ray...
Three types of N(H)-nucleophiles were used to study the nucleophilic addition CN group 2-propanenitrilium<italic>closo</italic>-decaborate cluster giving<italic>N-closo</italic>-decaborato amidrazones.
Abstract A newly introduced diazo reagent, 1‐diazo‐ N , ‐bis(4‐methoxybenzyl)methanesulfonamide, enables access to a range of azole‐based primary sulfonamides via [3+2] cycloaddition followed by protecting group removal. Such compounds are representative the sulfonamide chemical space highly relevant but hitherto not investigated in context inhibition therapeutically isoforms carbonic anhydrase enzyme. Using this three sets based on pyrazole, 1,2,3‐triazole and tetrazole cores were...
Heterocyclic nonacetamide ligands are used as positron emission tomography (PET) imaging agents of the synaptic vesicle glycoprotein 2A (SV2A), with potential applications in diagnosis various neuropsychiatric diseases. To date, main synthetic strategy to access these optically active compounds has involved racemic synthesis a late-stage intermediate followed by separation enantiomers. Here, we describe use iminium organocatalysis for asymmetric SynVesT-1, an important PET agent SV2A. The...
Abstract Biomolecules labeled with radioisotopes of iodine and fluorine play a major role in science medicine, range applications including molecular imaging disease, as radiopharmaceuticals for therapy tools drug discovery. Due to the relative stability Csp2–halogen bonds, radioiodine radiofluorine labels are commonly incorporated into tracers via arene substitution. The wide availability aryl boron reagents has led their use development radioiodination radiofluorination methods,...