A5054464938- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Nitric Oxide and Endothelin Effects
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Saffron Plant Research Studies
- Stress Responses and Cortisol
- Treatment of Major Depression
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Medicinal Plant Extracts Effects
- Anesthesia and Neurotoxicity Research
- Diet and metabolism studies
- Medicinal Plants and Bioactive Compounds
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Flavonoids in Medical Research
- Ion channel regulation and function
- Chemical synthesis and alkaloids
- Neuroinflammation and Neurodegeneration Mechanisms
- Hedgehog Signaling Pathway Studies
- Anesthesia and Sedative Agents
University of Thessaly
2016-2025
RMIT University
2014
University of Milan
2001-2003
Boehringer Ingelheim (Italy)
1993-2001
Boehringer Ingelheim (Germany)
1994-2001
Mario Negri Institute for Pharmacological Research
1990-1992
University Medical Center Utrecht
1990-1991
Abstract Background The deficiency of the gaseous molecule nitric oxide (NO) seems to be critically involved in pathogenesis schizophrenia. Thus, molecules that can normalize NO levels as are donors, might utility for medication this psychiatric disease. Aims & Objectives aim present study was detect ability donor molsidomine reduce schizophrenia-like impairments produced either by blockade N-methyl-D-aspartate (NMDA) receptor or dysregulation brain dopaninergic system rat. Method...
Abstract Rationale Anxiety is a chronic severe psychiatric disorder. In series of studies, the implication gaseous molecule nitric oxide (NO) in anxiety has been evidenced. Further, outcome preclinical research suggests that different NO donors, including sodium nitroprusside (SNP), have expressed an anxiolytic profile revealed animal models anxiety. Regardless this, it not yet clarified mechanism(s) action by which SNP induces its beneficial effects on this context, hypothesized these might...
Close to 19% of the world population suffers from anxiety. Current medications for this chronic mental disorder have improved treatment over last half century or more, but newer anxiolytics proved disappointing, and enormous challenges remain. Nitric oxide (NO), an intra- inter-cellular messenger in brain, is involved pathogenesis In particular, excessive NO production might contribute its pathology. This implies that it be useful reduce nitrergic activity; therefore, molecules aiming...