To assess the association of probiotics with depression, a large population-based cross-sectional study was conducted. National Health and Nutrition Examination Survey adult participants from 2005 through 2012 were included. Exposure defined as having consumed any probiotic food or supplement on interview days. Subjects classified depressed if Patient Questionnaire scores ≥10. Of 18,019 subjects included, 14.11% probiotics. Unadjusted analysis suggested that who had lower odds depression...

Background Treatment for depressive disorders often requires subsequent interventions. Patients who do not respond to antidepressants have treatment-resistant depression (TRD). Predicting will develop TRD may help healthcare providers make more effective treatment decisions. We sought identify factors that predict in a real-world setting using claims databases. Methods A retrospective cohort study was conducted US database of adult subjects with newly diagnosed and treated no mania,...

Abstract Aim Assess the association of flossing with periodontitis. Materials and Methods This was a cross‐sectional study using National Health Nutrition Examination Survey ( NHANES ) years 2011‐2014. We used three categories flossing: 0–1, 2–4 ≥5 days in past week CDC definition calculated odds ratios controlling for age, gender, smoking, drinking, income dentist visits. Results A total 6939 adult subjects were included, 35% flossed ≤1 time week, 40% had After adjustment, periodontitis 17%...

Study Objectives: To assess the clinical relevance of sleep duration, hours slept were compared by health status, presence insomnia, and depression, association duration with BMI cardiovascular risk was quantified.Methods: Cross-sectional analysis subjects in US National Health Nutrition Examination Surveys using adjusted linear logistic regressions.Results: A total 22,281 adults included, 37% ≤ 6 hours, 36% obese, 45% reported conditions.Mean 6.87 hours.Better associated more sleep.Subjects...

Depression that does not respond to antidepressants is treatment-resistant depression (TRD). TRD definitions include assessments of treatment response, dose and duration, implementing these in claims databases can be challenging. We built a data-driven definition evaluated its performance.We included adults with depression, ≥1 antidepressant, no diagnosis mania, dementia, or psychosis. Subjects were stratified into those without proxy for TRD. Proxies electroconvulsive therapy, deep brain,...

Parkinson's disease is a disorder growing in prevalence, disability, and deaths. Healthcare databases provide 'real-world' perspective for millions of individuals. We envisioned helping accelerate drug discovery by using these databases. The objectives this study were to assess the association marketed medications with risk parkinsonism four US claims evaluate consistency β-adrenoreceptor modulation parkinsonism. was conducted self-controlled cohort design which subjects served as their own...

Peripartum depression is a leading cause of disease burden for women and yet there little evidence as to how often peripartum does not respond treatment becomes resistant depression. We sought determine the incidence (TRD) in with Population based retrospective cohort study using large US claims database. was defined having diagnosis during pregnancy or up 6 months after end pregnancy. included prevalent incident The outcome development TRD within 1 year 3 distinct antidepressants...

Health services databases provide population-based data that have been used to describe the epidemiology and costs of treatment resistant depression (TRD). This retrospective cohort study estimated TRD incidence and, via sensitivity analyses, assessed variation within range implementation choices.In three US widely for observational studies, we defined as failure two medications evidenced by their replacement or supplementation other medications, set maximum durations (caps) how long a...

Objective Some patients who are given opioids for pain could develop opioid use disorder. If it was possible to identify at a higher risk of disorder, then clinicians spend more time educating these about the risks. We and validate model predict person's future disorder point before being dispensed their first opioid. Methods A cohort study patient-level prediction using four US claims databases with target populations ranging between 343,552 384,424 patients. The outcome recorded diagnosis...

This study sought to: 1. determine the frequency of rehospitalization with diagnosis suicidal ideation or suicide attempt (SI/SA) within a year and how often patients had multiple rehospitalizations; 2. identify time period for which risk is highest; 3. characteristics rehospitalizations. We conducted retrospective cohort adults depression using 4 US health claims databases. defined hospitalization as an inpatient emergency room visit codes indicating thoughts validated algorithm. Rates SI...

There is a knowledge gap regarding the treatment patterns of patients with major depressive disorder (MDD) who experience suicidal ideation or suicide attempt (SI/SA).Patients SI/SA were identified from large US-based claims database covering 84 million lives, during 1/1/2014-3/31/2020. Patients MDD indexed at their first diagnosis for and followed up to 365 days. Treatment captured class level included procedures electroconvulsive therapy transcranial magnetic stimulation, pharmacotherapy...

ClinicalTrials.gov is a registry and results database of federally privately supported clinical trials conducted worldwide. We sought to answer: what are the characteristics pain trials; how frequently these stopped why; magnitude attrition due lack efficacy or adverse events; whether withdrawal rates depend on syndrome. To facilitate this subsequent studies, we have developed system called Sherlock that automatically downloads data from into relational database. included interventional...

Opioid overdose deaths in the United States have climbed sharply over past two decades. Simultaneously, increased awareness of inadequately treated chronic pain has resulted opioid analgesic prescribing. The correlation between these phenomena led policymakers to posit that they are causally linked, and implement policy changes supporting safe prescribing.To evaluate impact its Analgesic Risk Evaluation Mitigation Strategy (REMS) program, US Food Drug Administration (FDA) requested...

Little is known about the prevalence of opioid shoppers in clinical practices and relation between prescriber characteristics risk having shoppers.Describe prescribers' practices. Assess patient shopping behavior.Retrospective cohort study using a large US retail prescription database.Patients with ≥1 dispensing were followed 18 months. These patients' prescribers are focus study.A was "shopper" if he or she had prescriptions written by day overlap filled at ≥3 pharmacies "heavy shopper" ≥5...

Background/Rationale: Little is known about the reasons for visiting multiple doctors/pharmacies, as doctor/pharmacy shopping, to obtain opioids. Objective: To investigate patients' self-reported shopping and assess whether behavior can be used a surrogate measure of opioid abuse/misuse. Methods: We conducted cross-sectional web-based survey among adult patients with ≥ 2 pharmacy claims immediate-release or extended-release/long-acting opioids between 7/1/2015 12/31/2016, identified from...

Introduction It is critical to assess who being treated with a new marketed drug like esketamine understand how it used in the real-world setting and effects of medication. Methods Retrospective analysis using two large U.S. health care databases that included commercially insured Medicaid patients. Patients were identified their baseline characteristics described compared patients treatment resistant depression (TRD) undergoing transcranial magnetic stimulation (TMS). To quantify...

Abstract Introduction Peripheral inhibition of tumor necrosis factor (TNF)‐α, outside the central nervous system, may result in clinical improvement Alzheimer's disease (AD) outcomes. TNF‐α inhibitors (TNFIs) are effective treatments for various autoimmune conditions and be preventing and/or treating AD. The objective this study was to compare risk dementia AD patients initiating methotrexate versus those TNFIs. Methods Insurance claims data from databases commercially insured...

Patients treated with vaccines based on NGlycolil gangliosides have showed benefit in progression free survival and overall survival. These molecules, which been observed breast cancer cells, are minimally or not expressed normal human tissue considered as antigen tumor-specific. For this reason they very attractive to immunotherapy. A phase I/II clinical trial was carried out metastatic patients the NGlycolylGM3/VSSP vaccine administered by subcutaneous route. Selecting optimal biological...

Major depressive and bipolar disorders are associated with impaired quality of life high economic burden. Although progress has been made in our understanding the underlying pathophysiology development novel pharmacological treatments, a large unmet need remains for finding effective treatment options. The purpose this study was to identify potential new mechanisms actions or targets that could inform future research opportunities major disorders.A self-controlled cohort conducted examine...