A5102710016- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- Protein Structure and Dynamics
- Photosynthetic Processes and Mechanisms
- Computational Drug Discovery Methods
- Glycosylation and Glycoproteins Research
- Plant Stress Responses and Tolerance
- Spectroscopy Techniques in Biomedical and Chemical Research
- bioluminescence and chemiluminescence research
- Liver Disease Diagnosis and Treatment
- Plant responses to elevated CO2
- Genomics and Phylogenetic Studies
- Bacterial Genetics and Biotechnology
- Cancer therapeutics and mechanisms
- ATP Synthase and ATPases Research
- Plant Parasitism and Resistance
- Viral Infections and Outbreaks Research
- Spectroscopy and Quantum Chemical Studies
- RNA and protein synthesis mechanisms
- Ammonia Synthesis and Nitrogen Reduction
- Receptor Mechanisms and Signaling
- Biotin and Related Studies
- Viral Infections and Vectors
- Urinary Bladder and Prostate Research
University of California, San Diego
2018-2024
Elon University
2016
Abstract Bacteria encode myriad defences that target the genomes of infecting bacteriophage, including restriction–modification and CRISPR–Cas systems 1 . In response, one family large bacteriophages uses a nucleus-like compartment to protect its replicating by excluding host defence factors 2–4 However, principal composition structure this remain unknown. Here we find bacteriophage nuclear shell assembles primarily from protein, which name chimallin (ChmA). Combining cryo-electron...
The continuing rise in the atmospheric carbon dioxide (CO2) concentration causes stomatal closing, thus critically affecting transpirational water loss, photosynthesis, and plant growth. However, primary CO2 sensor remains unknown. Here, we show that elevated triggers interaction of MAP kinases MPK4/MPK12 with HT1 protein kinase, inhibiting kinase activity. At low CO2, phosphorylates activates downstream negatively regulating CBC1 kinase. Physiologically relevant HT1-mediated phosphorylation...
Discovered in the 1920s, cytochrome bd is a terminal oxidase that has received renewed attention as drug target since its atomic structure was first determined 2016. Only found prokaryotes, we study it here for Mycobacterium tuberculosis (Mtb). Most previous discovery efforts toward have involved analogues of canonical substrate quinone, known Aurachin D. Here, report six new inhibitor scaffolds from computational screen and confirmed on activity through vitro testing. These provide avenues...
All protein simulations are conducted with varying degrees of simplification, oftentimes unknown ramifications about how these simplifications affect the interpretability results. In this work, we investigated glycosylation and lateral crowding effects modulate an array properties characterizing stability dynamics influenza neuraminidase. We constructed three systems: (1) glycosylated neuraminidase in a whole virion (i.e., crowded membrane) environment, (2) its own lipid bilayer, (3)...
Abstract Discovered in the 1920s, cytochrome bd is a terminal oxidase that has received renewed attention as drug target since its atomic structure was first solved 2016. Only found prokaryotes, we study it here for Mycobacterium tuberculosis ( Mtb ). Most previous discovery efforts towards have involved analogs of canonical substrate quinone, known Aurachin D. Here report six new inhibitor scaffolds determined from computational screen totaling over one million molecules and confirmed on...
Bacteria encode myriad defenses that target the genomes of infecting bacteriophage, including restriction-modification and CRISPR/Cas systems. In response, one family large bacteriophage employs a nucleus-like compartment to protect their replicating by excluding host defense factors. However, principle composition structure this remain unknown. Here, we find nuclear shell assembles primarily from protein, termed chimallin. Combining cryo-electron tomography shells in bacteriophage-infected...
Contributions by resonance and inductive effects toward the net activation barrier were determined computationally for gas-phase SN2 reaction between acetaldehyde enolate anion methyl fluoride, both O-methylation C-methylation, in order to understand why this favors O-methylation. With use of vinylogue extrapolation methodology, contribute increasing size about 9.5 kcal/mol 21.2 C-methylation. Inductive 1.7 4.2 Employing our block-localized wave function we contributions be 12.8 22.3 Thus,...
Plants respond to increased CO2 concentrations through stomatal closure, which can contribute water use efficiency. Grasses display faster responses than eudicots due dumbbell-shaped guard cells flanked by subsidiary working in opposition. However, forward genetic screening for signal transduction mutants grasses has yet be reported. The grass model Brachypodium distachyon is closely related agronomically important cereal crops, sharing largely collinear genomes. To gain insights into...
Cytochrome bd-type quinol oxidase is an important metalloenzyme that allows many bacteria to survive in low oxygen conditions. Since bd found prokaryotes but not eukaryotes, it has emerged as a promising bacterial drug target. Examples of organisms containing oxidases include the Mycobacterium tuberculosis (Mtb) bacterium causes (TB) humans, Vibrio cholerae cholera, Pseudomonas aeruginosa contributes antibiotic resistance and sepsis, Campylobacter jejuni food poisoning. Escherichia coli (E....
Schwann cells (SCs) undergo phenotypic transformation and then orchestrate nerve repair following a peripheral nervous system injury. The low-density lipoprotein receptor-related protein-1 (LRP1) is significantly upregulated in SCs response to acute injury, activating cJun promoting SC survival. Matrix-metalloproteinase-9 (MMP-9) an LRP1 ligand that binds through its hemopexin domain (PEX) activates survival signaling migration. To identify novel peptide mimetics within the of MMP-9, we...
Influenza virus has resurfaced recently from inactivity during the early stages of COVID-19 pandemic, raising serious concerns about nature and magnitude future epidemics. The main antigenic targets influenza are two surface glycoproteins, hemagglutinin (HA) neuraminidase (NA). Whereas structural dynamical properties both glycoproteins have been studied previously, understanding their plasticity in whole-virion context is fragmented. Here, we investigate dynamics a crowded protein...
Abstract Influenza neuraminidase is an important drug target. Glycans are present on neuraminidase, and generally considered to inhibit antibody binding via their glycan shield. In this work we studied the effect of glycans kinetics antiviral drugs influenza neuraminidase. We created all-atom in silico systems with experimentally-derived glycoprofiles consisting four different conformations one system without glycans. Using Brownian dynamics simulations, observe a two- eight-fold decrease...
All protein simulations are conducted with varying degrees of simplifications, oftentimes unknown ramifications on how these simplifications affect the interpretability results. In this work we investigated glycosylation and lateral crowding effects modulate an array properties characterizing stability dynamics influenza neuraminidase. We constructed three systems: 1) Glycosylated neuraminidase in a whole virion (i.e. crowded membrane) environment 2) its own lipid bilayer 3) Unglycosylated...
Abstract Plants respond to increased CO 2 concentrations through rapid stomatal closure which can contribute water use efficiency. Grasses display faster responses than eudicots due dumbbell-shaped guard cells flanked by subsidiary working in opposition. However, forward genetic screening for signal transduction mutants grasses has not been reported. The grass model Brachypodium distachyon is closely related agronomically important cereal crops, sharing largely collinear genomes. To gain...
You have accessJournal of UrologyModerated Poster 57, Wednesday, May 23, 2007 1:00 - 3:00 pm1 Apr 20071834: Evaluation the long term Efficacy, Safety and Retreatment rates Targeted high Energy Transurethral Microwave Thermotherapy Matthias Waldert, Christian Seitz, Mike Harik, Said Alavi, Markus Margreiter, Piotr Dobronski, Vincent Ravery, Martina Nowak, Amir Kaisary, Michael Marberger, Bob Djavan WaldertMatthias Waldert More articles by this author , SeitzChristian Seitz HarikMike Harik...
You have accessJournal of UrologyStone Disease: Surgical Therapy VI1 Apr 2018MP89-08 STONE CULTURE IS NOT BETTER THAN BLADDER URINE AS SIRS PREDICTOR AFTER PERCUTANEOUS NEPHROLITHOTOMY Alfio Corsaro, Mehmet Özsoy, Julian Veser, and Christian Seitz CorsaroAlfio Corsaro More articles by this author , ÖzsoyMehmet Özsoy VeserJulian Veser SeitzChristian View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2948AboutPDF ToolsAdd to favoritesDownload CitationsTrack...