A5088140436- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- Pluripotent Stem Cells Research
- Cancer Cells and Metastasis
- Neuroscience and Neural Engineering
- Single-cell and spatial transcriptomics
- Tissue Engineering and Regenerative Medicine
- Innovative Microfluidic and Catalytic Techniques Innovation
- Research in Cotton Cultivation
- Spaceflight effects on biology
- Congenital heart defects research
- Planarian Biology and Electrostimulation
- Irrigation Practices and Water Management
- Lymphatic System and Diseases
Technion – Israel Institute of Technology
1984-2024
Abstract In vitro models of the pancreas can aid in developing therapies for pancreatic diseases. Nonetheless, most tissue engineering is limited to insulin‐secreting β‐cells or adenocarcinoma models. Combining all essential components, including exocrine, endocrine, and blood vasculature, crucial recapitulate native organization. this study, extrusion‐based 3D bioprinting create constructs containing both endocrine exocrine compartments exploited. Mouse pluripotent stem cell‐derived...
Significance Lymphatic vessel networks are important for various biological processes; thus, incorporating them into engineered constructs can have both research and clinical implications. Engineered lymphatic vessels improve biomimicry functionality of in vitro tissue assays serve as a treatment diseases associated with impaired function. In this work, we created functional that anastomosed to the host system postimplantation. We investigated effect supporting cells, cell-secreted...
The developing mouse pancreas is surrounded by mesoderm compartments providing signals that induce formation. Most pancreatic organoid protocols lack this niche and only partially capture the cell repertoire. This work aims to generate aggregates differentiating embryonic stem cells (mESCs) into progenitors (MPs) (PPs), without using Matrigel. First, mESCs were differentiated epiblast (EpiSCs) enhance PP differentiation rate. Next, PPs MPs aggregated together giving rise various types,...
Abstract The developing mouse pancreas is surrounded by mesoderm compartments providing signals that induce formation. Most pancreatic organoid protocols lack this niche and only partially capture the cell repertoire. This work aimed to generate aggregates differentiating embryonic stem cells (mESCs) into progenitors (MPS) (PPs), without using extracellular matrix substitutes. First, mESCs were differentiated epiblast (EpiSCs) enhance PP differentiation rate. Next, PPs MPs aggregated...